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Coenzyme Q10

Nutrient Name: Coenzyme Q10.
Synonyms: Coenzyme Q, coQ10, ubidecarenone; co-enzyme Q10, coQ10-alpha-cyclodextrin, coenzyme Q (50), coQ, coQ(50), co-Q10, coQ-10, 2,3 dimethoxy-5 methyl-6-decaprenyl benzoquinone, mitoquinone, Q10, ubiquinone, ubiquinone-10, ubiquinone-Q10, vitamin q10, vitamin Q10.
Related Substance: Ubiquinol (QH).
Synthetic Analog: Idebenone (water soluble).
Trade Names: Andelir, Cavamax W8/CoQ10, Heartcin, Neuquinone, Taidecanone, UBTH, Udekinon.

Summary Table
nutrient description

Chemistry and Form

Coenzyme Q10 (coQ10) belongs to a family of compounds known as ubiquinones, all of which are characterized by a functional group known as a benzoquinone . Ubiquinones are fat-soluble molecules with between 1 and 12 isoprene (5-carbon) units. Among the 10 naturally occurring coenzyme Q compounds, the ubiquinone found in humans is known as coenzyme Q10 because of the distinctive “tail” of 10 isoprene units (containing 50 carbons in toto) attached to its benzoquinone “head.”

Physiology and Function

In humans, coQ10 is synthesized in most tissues throughout the body. Three major steps are involved in the endogenous synthesis of coQ10: (1) synthesis of the benzoquinone structure from tyrosine or phenylalanine, (2) synthesis of the isoprene side chain from acetyl coenzyme A (CoA) via the mevalonate pathway, and (3) the condensation or merging of these two structures. 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase is the critical enzyme regulating coQ10 synthesis as well as cholesterol synthesis.

Coenzyme Q is highly soluble in lipids and is found in virtually all cell membranes, as well as lipoproteins. The primary biochemical action of coQ10 is as a coenzyme for numerous enzymes in the electron transport chain, a series of oxidation-reduction (redox) reactions involved in cellular respiration, where the presence of coQ in the inner mitochondrial membrane is required for the conversion of energy from carbohydrates and fats in the synthesis of adenosine triphosphate (ATP). Within the mitochondrial electron transport chain, coQ accepts electrons from reducing equivalents generated during fatty acid and glucose metabolism and transfers them to electron acceptors. Simultaneously, a proton gradient across that membrane results when coQ transfers protons outside the inner mitochondrial membrane. When the protons subsequently flow back into the mitochondrial interior, energy is released to form ATP.

Coenzyme Q10 has dual potential to enhance energy production by bypassing defective elements of the respiratory energy production chain and through its function as an antioxidant. Coenzyme Q can exist in three oxidation states: (1) the fully reduced ubiquinol form (CoQH2), (2) the radical semiquinone intermediate (CoQH), and (3) the fully oxidized ubiquinone form (CoQ). Thus, in its central role as a pro-oxidant within mitochondria, coQ10 enables aerobic energy gain, promotes unilateral proton accumulation, and generates reactive oxygen species (ROS) involved in physiological signaling. Ubiquinone can execute reversible addition of single electrons and protons. Lysosomal membranes critical to cellular detoxification and recycling contain particularly high concentrations of coQ. Recent research indicates that lysosomal ubiquinone maintains the optimal pH for cellular recycling through its double function as proton translocator and radical source, particularly under certain metabolic conditions such as an acid pH. Alternately, a range of research demonstrates a pervasive and potent role of coenzyme Q10 in protecting membranes and DNA from oxidative damage from free radicals directly and through suppression of the formation of oxidized lipids and the consumption of alpha-tocopherol. As a lipophilic molecule, the reduced form of coQ, coQH2, along with enzymes that are capable of reducing oxidized coQ back to coQH2, is particularly concentrated in mitochondrial cell membranes, where it acts as a key cellular antioxidant and provides protection against free-radical damage. However, the type of biomembrane where ubiquinone exerts its free-radical, chain reaction–breaking activity can significantly affect this action’s efficiency. Furthermore, coQH2regenerates alpha-tocopherol radicals back to the chain-breaking (i.e., antioxidant) form of vitamin E and thereby further contributes to the control of lipid peroxidation. This ability to counteract oxidative stress is particularly evident in its support of healthy cardiac tissue and its protection of endothelial function. Thus, coQ10’s unique chemistry enables it to function both as a pro-oxidant and as an antioxidant.

nutrient in clinical practice

Known or Potential Therapeutic Uses

Coenzyme Q10 can be synthesized in vivo by all living organisms, including humans, and thus is not defined as a vitamin. However, in some situations, the need for coQ10 may surpass the body’s ability to synthesize it, so it may be regarded as “conditionally essential.” CoQ10 is well absorbed by oral administration, as evidenced by significant increases in serum, plasma, and lipoprotein concentrations of coQ10 after oral intake. 1,2However, evidence from animal and human research is mixed as to the degree to which oral intake elevates levels in various target tissues, and how that effect might vary depending on state of health, influence of aging, and presence of dysfunction, depletion, or pathology in particular tissues and systems. 3-7

In 1958, Professor Karl Folkers elucidated the chemical structure of coQ10 and noted its potential in the treatment of cardiovascular disease. However, his employer, Merck, chose to sell the formula and patent to a Japanese firm in favor of promoting Diuril, a new product at the time aimed at the cardiovascular drug market. Thus, although coQ10 developed a strong presence in medical and supplement markets in Japan, its entry into clinical use in the United States has been delayed but is steady growing.

Possible Uses

Alzheimer’s disease, angina, arrhythmia, breast cancer, cardiac bypass surgery, cardiomyopathy, cardiovascular disease, cerebellar ataxia (familial), chemotherapy support, chronic fatigue, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), diabetes mellitus, diastolic dysfunction, fibromyalgia, gingivitis, human immunodeficiency virus (HIV) support, Huntington’s disease, hypertension, immune deficiencies, insulin resistance syndrome, ischemia, lung cancer, male infertility, mitochondrial diseases, mitral valve prolapse, muscular dystrophies, myocardial infarction, neurodegenerative diseases, Parkinson’s disease, periodontal disease, prostate cancer, renal failure, rhabdomyolysis.

Oral administration may also enhance aerobic capacity and muscle performance, especially in sedentary and elderly individuals. Conclusive evidence from large clinical trials has yet to be carried out to investigate this proposed action.

Deficiency Symptoms

The deficiency pattern associated with coQ10 has not been clearly defined, and it is widely assumed that endogenous production and a varied diet provide adequate coQ10 for most individuals. A deficiency may result from impaired synthesis caused by nutritional deficiencies, acquired defect in synthesis or utilization, or increased tissue needs resulting from illness. Most coQ10 in humans is internally synthesized. Genetic defects in coQ10 synthesis and metabolism are considered rare at this time. Deficiency can be caused or aggravated by depletion or deficiency of any of the many nutrients required within this 17-stage synthetic pathway, including riboflavin (vitamin B2), niacinamide (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), cobalamin (vitamin B12), folic acid, vitamin C, and several trace elements. As might be expected, given the central role of the HMG-CoA reductase enzyme in the coQ10 synthetic pathway, HMG-CoA reductase inhibitors (“statins”), which are widely prescribed for management of dyslipidemias and cardiovascular disease, have been implicated as an iatrogenic cause of coQ10 deficiencies.

CoQ10 concentrations in various tissues decline with advancing age, and elderly individuals are known generally to have lower levels of coQ10. 8,9Likewise, researchers have observed that the patient populations exhibiting many of the conditions coQ10 is used to treat more often demonstrate low levels of coQ10; these include cardiomyopathy, gingivitis and periodontal disease, heart failure, and HIV/AIDS. Many researchers and clinicians consider at least a CHF subset to represent a coQ10 deficiency disease, to a significant degree. Decreased plasma levels of coQ10 have also been observed in individuals with diabetes and cancer. Lastly, individuals with the genetic polymorphisms called the LPL and NQO1 genotypes exhibit decreased coQ10 redox ratios, reflective of impaired ability to convert ubiquinone to ubiquinol. 10

Dietary Sources

Coenzyme Q10 is widely distributed in foods but in such small amounts that extraordinary serving sizes would be required to obtain intake levels typically provided by commercial preparations (e.g., 100 mg daily).

Organ meats (e.g., heart, liver), meat, poultry, and fish are the richest dietary sources of coenzyme Q10. Nuts provide relatively high levels, as do soybean and canola oils. Vegetables, fruits, eggs, and dairy products contain moderate levels of coQ10, with broccoli and spinach being relatively richer.

Studies in Denmark conducted during the 1990s found that average dietary intake of coQ10 was 3 to 5 mg per day. 11,12Overall, dietary sources appear to provide most individuals with less than 10 mg/day. Foods are estimated to provide an average of 25% of plasma coQ10 in most individuals. Boiling appears to have little adverse effect, but frying destroys 14% to 32% of coQ10 in foods thus prepared. The precise dietary contribution to plasma coQ10 concentration is unknown in any given individual but is estimated to be approximately 25%.

Nutrient Preparations Available

Microcrystalline cellulose-coQ10 complex.

Complexing coenzyme Q10 with alpha-cyclodextrin may enhance bioavailability of coQ10 by approximately 35% compared to a microcrystalline cellulose-coQ10 complex. 13

Ubiquinol (QH) is the converted active form of coQ10. The conversion rate of coQ10 (ubiquinone) to ubiquinol tends to decline with age, rendering lowered serum levels of ubiquinol. Furthermore, LPL and NQO1 genotypes are associated with impaired ability to conduct this conversion. 10 However, outside the body, ubiquinol is extremely unstable without certain stabilizing procedures because it will convert to coQ10 on exposure to oxygen. 14 Since ubiquinone must be reduced to become active, oral ubiquinol may provide bioavailability up to eight times as great as that of oral ubiquinone.

Dosage Forms Available

Powder-filled hard-shell capsule, soft-gel capsule, liposomal spray, tablet, chewable wafer.

Oral coenzyme Q10 should be taken with a meal with some fat content since it is fat-soluble. Absorption decreases in the absence of lipid. Some experts suggest taking coQ10 with a small amount of olive oil to increase absorption. There is some evidence that coQ10 in oil suspension provides better bioavailability than granular form. 15-17Chewable forms may also provide greater bioavailability than capsules or tablets.

Source Materials for Nutrient Preparations

Yeast fermentation, or semisynthetic process.

Kaneka Corporation of Japan, which is the only company to use yeast fermentation in the production of coQ10, produces the natural all- trans Q, which is identical to the coQ10 occurring in nature and has succeeded in obtaining “generally recognized as safe” (GRAS) status from the U.S. Food and Drug Administration (FDA). 18

Dosage Range

Adult

Dietary: No level has been established for optimal dietary intake of coenzyme Q10.

Supplemental/Maintenance: 25 to 60 mg twice daily.

Pharmacological/Therapeutic: Ranging from 30 to 60 mg twice daily to 50 to 100 mg two to three times daily, depending on condition and in concert with a health care professional trained in nutritional therapies. Daily dosage levels of 300 to 600 mg have been used in clinical and research settings in the treatment of conditions such as severe cardiovascular disease and advanced breast cancer. Administration of 60 to 100 mg per day will usually double plasma levels of coQ10 in adults. Evidence indicates that oral intake does not impair endogenous coQ10 synthesis.

Toxic: None established.

Pediatric (<18 Years)

Coenzyme Q10 is usually not prescribed for infants or children.

Laboratory Values

Plasma and lymphocyte coenzyme Q10 and coenzyme Q10H2levels.

safety profile

Overview

All available evidence indicates that coenzyme Q10 is generally safe. No significant adverse effects or toxicities have been reported as being associated with oral intake of coQ10. CoQ10 in doses up to 900 mg daily is safe and well tolerated in healthy adults for 4 weeks. 19 Even continued doses of 600 mg/day for 30 months and 1200 mg/day for up to 16 months have not been associated with significant adverse effects. 20,21

Nutrient Adverse Effects

General Adverse Effects

Occasional reports of mild nausea, gastrointestinal (GI) discomfort, anorexia, or skin eruptions have been reported with oral intake of coQ10. Other reported adverse effects include fatigue, insomnia, headache, dizziness, irritability, photosensitivity, dyspepsia, vomiting, diarrhea, dermatitis, or flulike symptoms. Reported adverse effects typically receded when oral coQ10 was stopped or dosage levels or format were modified. Dividing daily intake into two or three dosages may eliminate adverse effects, especially if more than 100 mg/day is being used.

Pregnancy and Nursing

Adverse effects are not predicted, and reports are lacking. However, the lack of controlled studies involving pregnant or lactating women precludes claims of safety and suggests that oral intake should be avoided during such life cycles.

Infants and Children

Adverse effects are not predicted, and reports are lacking. CoQ10 administration is not recommended unless otherwise indicated as essential.

Contraindications

No contraindications have been established for coQ10.

Precautions and Warnings

No precautions or warnings are known at this time for healthy individuals. Individuals with CHF or other serious cardiovascular conditions should only discontinue coQ10 under the supervision of the prescribing health care professional; withdrawal of coQ10 intake could potentially contribute to relapse.

Cautions have been voiced regarding coQ10 use by individuals with diabetes, hypoglycemia, hypertension, or liver disease. Evidence to substantiate clinically significant adverse events is limited. Supervision and appropriate monitoring are usually adequate in most cases.

interactions review

Strategic Considerations

The primary clinical uses of coenzyme Q10 supported by human trials are in the treatment of CHF, angina pectoris, mitochondrial encephalopathies, mitochondrial cytopathies, chronic myalgic conditions, dystrophies, fibromyalgia, and Parkinson’s disease. In such conditions characterized by mitochondrial dysfunction, the functions of coQ10 in mitochondrial bioenergetics and protection against oxidative stress appear to be paramount. CoQ10’s strong antioxidant activity also enables it to function as an effective therapeutic ally when administered in conjunction with medications, such as doxorubicin, that cause adverse effects as a result of inducing oxidative damage. Virtually all antioxidants are capable of functioning as pro-oxidants, either when present in overwhelming quantity (e.g., high-dose intravenous ascorbate) or when present with inadequate antioxidant network partners in an environment of high oxidative stress (e.g., smokers with poor dietary antioxidant intake who are supplemented with synthetic beta-carotene). Perhaps the unique aspect of coQ10 is that it functions physiologically both as a pro-oxidant and antioxidant and can be regenerated back to its reduced or antioxidant form through normal cellular enzymatic processes.

Many pharmacological agents inhibit coQ10 synthesis, interfere with its function, and induce coQ10 deficiency states. In such circumstances, coadministration of coQ10 can prevent or reverse adverse drug effects, often in a manner that enhances therapeutic efficacy and improves clinical outcomes. In these situations, coQ10 carries no significant risks, and controversy as to its use is minimal.

Coenzyme Q10 is most widely used in the prevention and treatment of heart disease, more recently incorporated into acute cardiac care. For example, in an innovative placebo-controlled randomized trial involving 49 patients, Damian et al. 22 found that combining liquid coQ10 (250 mg followed by 150 mg three times daily for 5 days) with mild hypothermia immediately after out-of-hospital cardiac arrest and cardiopulmonary resuscitation (CPR) appears to improve survival and may prevent reperfusion injury and neurological damage in survivors. The astroglial protein S100 is an established biochemical marker of central nervous system (CNS) injury. Mean serum S100 protein 24 hours after CPR was significantly lower in the coQ10 group (0.47 vs. 3.5 ng/mL). Three-month survival in the coQ10 group was 68% versus 29% in the placebo group, and nine coQ10 patients survived with a Glasgow outcome scale of 4 or 5 (vs. five placebo patients). As for chronic cardiovascular conditions and attendant mortality risk, evidence is not unanimously in support of its efficacy, but as part of a lifestyle that includes regular exercise and a healthy diet (particularly omega-3 oils), coQ10 may help significantly decrease cardiovascular risk. 23 In particular, chronic CHF has reached epidemic proportions and is the single most common cause for hospitalization among individuals over age 65 in the United States; in more than half these patients, impaired left ventricular (LV) diastolic function plays a major role. CoQ10 appears to provide particular benefit in reversing diastolic impairment, including adverse effects on LV diastolic function associated with atorvastatin therapy. 24 This therapeutic action, as well as the broader role of coQ10 in the treatment of chronic cardiovascular conditions, leads directly into what may become a major controversy within medicine.

The issue of the interaction between statin drugs and coenzyme Q10 presents some of the most complex and timely clinical issues affecting coQ10 and its role in human health. HMG-CoA reductase inhibitors have demonstrated important and substantial cardiovascular clinical benefits, including reducing mortality; however, the impact of coQ10 depletion with long-term statin therapy (≥20 years) is only beginning to be considered in a substantive manner, particularly concerning patients with heart failure. Nevertheless, in the first clinical research addressing some of these concerns, Go et al. 25 conducted a propensity-adjusted cohort study of all-cause death and hospitalization for heart failure during a median of 2.4 years of follow-up after initiation of statin therapy. They reported that among “adults diagnosed with heart failure who had no prior statin use, incident statin use was independently associated with lower risks of death and hospitalization among patients with or without coronary heart disease.” Although encouraging, the short duration of follow-up in this study precludes any substantive conclusions regarding long-term safety of statin therapy.

The medical literature currently portrays statin therapy as a virtual “panacea” for prevention and treatment of cardiovascular conditions (and a multitude of other pathologies), but the parameters of the statin discussion have yet to expand beyond cholesterol and inflammation and incorporate comprehensive functional assessment of all risk factors. In a paper with potentially disturbing implications, Getz et al. 26 discussed the issue of estimating the high-risk group for cardiovascular disease in a well-defined Norwegian population according to European guidelines and the systematic coronary risk evaluation system. They raised concerns regarding the efficacy of applying the current cholesterol reduction goals (of total cholesterol below 180 mg/dL) being established as public policy in Europe and the United States. They noted that, in Norway, one of the world’s healthiest countries, 85% of the men and more than 20% of the women over age 40 would need to be treated for high cholesterol under the American recommendations. Thus, in this population with relatively low rates of heart disease, “implementation of the 2003 European guidelines on prevention of cardiovascular disease in clinical practice would classify most adult Norwegians at high risk for fatal cardiovascular disease.” 26 These observations prompted provocative responses in the scientific literature questioning the necessity, safety, and prudence of broad-based implementation of aggressive lipid-lowering standards. In particular, Ravnskov et al. 27 pointed out that application of these recommendations would result in the majority of the world’s adult population being treated with statin drugs; to which they added, “As the risk to benefit ratio for a more drastic lowering of low density lipoprotein cholesterol is unknown, we question the wisdom of this advice.” Notably, May et al. 28 found that a total cholesterol level approaching 200 mg/dL is associated with higher survival in patients with heart failure than levels below 140 mg/dL.

Paradoxical evidence showing both reduced cardiovascular risk, including heart attack and stroke, and stress on cardiac tissue induced by the inherent action of HMG-CoA reductase inhibitors has yet to withstand the test of time over decades. Although 20 years may be required for ongoing inhibition of endogenous ubiquinone synthesis resulting in mitochondrial interference and diastolic dysfunction to manifest as impaired hepatic, neurological, and cardiac dysfunction or frank cardiomyopathy resulting in chronic CHF, long-term statin use could represent a significant iatrogenic risk factor for some patients, particularly those with baseline coQ10 levels that are suboptimal or compromised by aging, malnutrition, drug depletions, genotypic susceptibility, and other adverse influences. Thus, for example, Tsivgoulis et al. 29 found that patients with asymptomatic neuromuscular disorders may have their condition precipitated by statin use.

Although statin therapy may reduce inflammation, as reflected by reduced C-reactive protein (CRP) concentrations, other critical cardiovascular risk factors such as lipoprotein(a), homocysteine, and fibrinogen are not modified to any significant degree by inhibition of HMG-CoA reductase. Moreover, preliminary research indicates that hypotheses of reduced atherosclerosis and calcific aortic stenosis through aggressive lipid-lowering therapies using statins may have been premature and overly optimistic in the face of mixed findings; in fact, statins appear to block the beneficial effects of exercise on intimal thickening. 30,31Likewise, in the IDEAL study comparing high-dose atorvastatin with usual-dose simvastatin for secondary prevention after myocardial infarction (MI), Pedersen et al. 32 found that although aggressive lipid lowering significantly reduced the risk of other composite secondary endpoints and nonfatal acute MI, intensive lowering of low-density lipoprotein (LDL) cholesterol did not reduce coronary death or cardiac arrest with resuscitation, and that there were no differences in cardiovascular or all-cause mortality.

Thus far, the potential for integrative clinical strategies based on synergistic activities has been neglected and may be most deserving of thorough investigation. A thorough review of the literature of statin therapy that incorporates a frank appraisal of risk factors suggests that the growing enthusiasm for statin drugs over the past decade may eventually succumb to a harsh realization that they are appropriate for a relatively select patient population, specifically those with severe and recalcitrant hypercholesterolemia for whom other therapies have proved ineffectual. Notably, the issue of individual pharmacogenomic variability influencing efficacious or adverse responses to statin therapy is only beginning to be considered. 33 Furthermore, until continued concerns about neuropathies, skeletal myopathies, and cardiomyopathies known or suspected to be associated with long-term statin therapy, as well as their potential for enhancing growth of subclinical malignancies through angiogenic and possibly immunomodulating mechanisms, are more fully investigated, the use of these widely prescribed, arguably overprescribed, medications should be more carefully considered, given the paucity of long-term studies of these agents, which, once instituted, will often be consumed for the lifetime of most patients. For example, in a retrospective case-control study, Wilke et al. 34 found that CYP3A genotype was associated with increased severity of atorvastatin-induced muscle damage, but not an increased risk for development of such adverse effects, as indicated by elevated serum creatine kinase (CK) levels. Thus, individuals who were homozygous for CYP3A5*3 demonstrated greater serum CK levels than patients who were heterozygous for CYP3A5*3, when concomitant lipid-lowering agents (gemfibrozil with or without niacin) were sequentially removed from the analysis. Similarly, in comparing nine haplotypes in the gene that carries the code for HMG-CoA reductase within both Caucasian and African Americans, Krauss et al. 35 found that treatment with simvastatin (40 mg) demonstrated significant genetic differences in statin response in lowering LDL cholesterol levels. Consequently, individuals who have a genetic problem with metabolizing statins could have a larger depletion of coQ10 (because of a higher level of the statin drug) and thus could have more problems. conversely, individuals who tolerate statins better may be metabolizing them faster, and thus their Q10 may not become as depleted. Moreover, half of all individuals who have heart attacks do not have hypercholesterolemia.

Meanwhile, other methods of cardiovascular disease risk reduction, such as a healthy and balanced diet, regular exercise, and omega-3 fatty acid supplementation, should be pursued vigorously as a coordinated broad response to multiple risk factors. In such an integrative approach, for example, the therapeutic benefits of statin therapy can be complemented or enhanced through coadministration of fish oil orL-carnitine. 36-43Nevertheless, when Studer et al. 23 conducted a review of data on the efficacy and safety of different antilipidemic agents and diets on mortality, they found that fish oil and statins were the most effective interventions for lowering cardiac mortality risk, fish oil being superior to statin therapy in terms of lowering all-cause mortality, despite very modest effects on lipids.

However, other evidence has emerged that could complicate the picture. In a 6-year, randomized, controlled trial involving 140 middle-aged men, Rauramaa et al. 30 found that men undergoing statin treatment are significantly less likely to exhibit benefit from exercise in slowing atherosclerosis than those exercising but not taking statins. Intermittent exercise enhances coQ10 biosynthesis, resulting in higher coQ10 levels, and this could be a factor in the well-known health benefits of exercise. The findings from this study suggest that statins may neutralize the beneficial effect of exercise, at least in part, through their blocking of coQ10 biosynthesis. Levy and Kohlhaas 44 conducted a review of studies examining the effects of statin drugs, prescribed for reduction of cholesterol levels, on plasma concentrations of coQ10 and considerations regarding coadministration of coQ10 and concluded that “statin drug therapy does indeed reduce blood concentrations of coenzyme Q10.” However, the authors determined that “due to the small number and dissimilar nature of studies available, the ability of the reviewers to draw any strong conclusions was limited.” Nevertheless, “results from isolated studies suggest that statin drugs may induce mitochondrial dysfunction.” Furthermore, “limited data suggest that supplementation with coenzyme Q10 may be beneficial in patients taking statin drugs who 1) have a family history of elevated cholesterol levels, or 2) have a family history of heart failure, or 3) are over 65 years of age. Further studies investigating the effects of statin drugs on the development of myotoxicity are warranted, particularly among high-risk populations.” 44 Continued research is needed to investigate the long-expressed hypothesis that many of the other adverse effects associated with statins derive from its interference with coQ10 synthesis and function.

Administration of coQ10 alone or in conjunction with other agents, as part of an integrative therapeutic strategy, offers significant potential for enhancing clinical outcomes in individuals with a range of cardiovascular conditions. In particular, numerous researchers and clinicians have reported many cases of extraordinary clinical improvement in individuals with conditions such as CHF in which the expected progression is characterized by steady worsening and morbidity within 2 years under conventional therapy. At the least, incorporation of coQ10 into the therapeutic repertoire presents an opportunity to correct myocardial deficiency of coQ10 and enhance synthesis of coQ10-requiring enzymes, thereby extending the duration and enhancing the quality of life of such patients.

nutrient-drug interactions
Beta-1-Adrenoceptor Antagonists (Beta-1-Adrenergic Blocking Agents) and Related Antihypertensive Medications
Chlorpromazine, Thioridazine, and Related Phenothiazines
Doxorubicin and Related Anthracycline Chemotherapy
HMG-CoA Reductase Inhibitors (Statins)
Sulfonylureas and Related Oral Hypoglycemic Agents
Tricyclic Antidepressants (TCAs)
Warfarin and Related Oral Vitamin K Antagonist Anticoagulants
theoretical, speculative, and preliminary interactions research, including overstated interactions claims
Fenofibrate, Gemfibrozil, and Related Fibrates
Hydrochlorothiazide and Related Thiazide Diuretics
Levothyroxine and Related Thyroid Hormones
Orlistat
Pentoxifylline
Radiotherapy
Zidovudine (AZT) and Antiretroviral Agents, Reverse-Transcriptase Inhibitor (Nucleoside)

Evidence: Zidovudine (azidothymidine, AZT, ZDV, zidothymidine; Retrovir); combination drugs: zidovudine and lamivudine (Combivir); abacavir, lamivudine and zidovudine (Trizivir).

Extrapolated, based on similar properties: Abacavir (Ziagen), didanosine (ddI, dideoxyinosine; Videx), dideoxycytidine (ddC, zalcitabine; Hivid), lamivudine (3TC, Epivir), stavudine (D4T, Zerit), tenofovir (Viread).

Zidovudine (AZT/ZDV) has been associated with “ragged-red” fiber myopathy because of its effects on myocyte mitochondria; this condition typically is reversible with cessation of the drug. Rosenfeldt et al. 120 reported the case of a 52-year-old male who first developed ragged-red fiber myopathy in 1985 while on effective ZDV-based combination antiretroviral therapy (ART), 14 years after diagnosis of HIV infection. The patient demonstrated “an excellent recovery” after administration of coQ10, known for its antioxidant activity in mitochondria, and was able to continue ART without disruption. The authors concluded that this response to coQ10 therapy “suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV.”

nutrient-nutrient interactions
SMALLCAPS L END_SMALLCAPS -Carnitine
Vitamin B 6 , Pyridoxine, Pyridoxal 5′-Phosphate
Vitamin E, Alpha-Tocopherol
herb-nutrient interactions
Ginkgo
Citations and Reference Literature
  • 1.Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1992;1126:247-254.
  • 2.Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20:591-598.View Abstract
  • 3.Zhang Y, Aberg F, Appelkvist EL et al. Uptake of dietary coenzyme Q supplement is limited in rats. J Nutr 1995;125:446-453.View Abstract
  • 4.Lonnrot K, Holm P, Lagerstedt A et al. The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice. Biochem Mol Biol Int 1998;44:727-737.View Abstract
  • 5.Matthews RT, Yang L, Browne S et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A 1998;95:8892-8897.View Abstract
  • 6.Svensson M, Malm C, Tonkonogi M et al. Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise. Int J Sport Nutr 1999;9:166-180.
  • 7.Rosenfeldt FL, Pepe S, Linnane A et al. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. Biogerontology 2002;3:37-40.View Abstract
  • 8.Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24:579-584.View Abstract
  • 9.Soderberg M, Edlund C, Kristensson K, Dallner G. Lipid compositions of different regions of the human brain during aging. J Neurochem 1990;54:415-423.
  • 10.Miles MV, Morrison JA, Horn PS, et al. LPL and NQO1 genotypes are associated with decreased coenzyme Q10 redox ratio. International Congress of Clinical Chemistry and American Association for Clinical Chemistry Annual Meeting; 2005.
  • 11.Weber C, Bysted A, Hllmer G. The coenzyme Q10 content of the average Danish diet. Int J Vitam Nutr Res 1997;67:123-129.View Abstract
  • 12.Overvad K, Diamant B, Holm L et al. Coenzyme Q10 in health and disease. Eur J Clin Nutr 1999;53:764-770.View Abstract
  • 13.Terao K, Nakata D, Fukumi H et al. Enhancement of oral bioavailability of coenzyme Q10 by complexation with alpha-cyclodextrin in healthy adults. Nutr Res 2006;26:503-508.
  • 14.Ueda T, Ono T, Moro M et al. Method of stabilizing reduced coenzyme Q10. US patent application: US 2005/008630 A1; 2005.
  • 15.Weis M, Mortensen SA, Rassing MR et al. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med 1994;15 Suppl:s273-s280.View Abstract
  • 16.Kaikkonen J, Nyyssonen K, Porkkala-Sarataho E et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 1997;22:1195-1202.View Abstract
  • 17.Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 1998;68:109-113.View Abstract
  • 18.Langsjoen PH. Personal communication with MB Stargrove. May 2004.
  • 19.Ikematsu H, Nakamura K, Harashima SI et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 2006;44:212-218.
  • 20.A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology 2001;57:397-404.
  • 21.Shults CW, Oakes D, Kieburtz K et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59:1541-1550.View Abstract
  • 22.Damian MS, Ellenberg D, Gildemeister R et al. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation 2004;110:3011-3016.View Abstract
  • 23.Studer M, Briel M, Leimenstoll B et al. Effect of different antilipidemic agents and diets on mortality: a systematic review. Arch Intern Med 2005;165:725-730.View Abstract
  • 24.Silver MA, Langsjoen PH, Szabo S et al. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q(10) to reverse that dysfunction. Am J Cardiol 2004;94:1306-1310.View Abstract
  • 25.Go AS, Lee WY, Yang J et al. Statin therapy and risks for death and hospitalization in chronic heart failure. JAMA 2006;296:2105-2111.View Abstract
  • 26.Getz L, Sigurdsson JA, Hetlevik I et al. Estimating the high risk group for cardiovascular disease in the Norwegian HUNT 2 population according to the 2003 European guidelines: modelling study. BMJ 2005;331:551.View Abstract
  • 27.Ravnskov U, Rosch PJ, Sutter MC, Houston MC. Should we lower cholesterol as much as possible? BMJ 2006;332:1330-1332.
  • 28.May HT, Muhlestein JB, Carlquist JF et al. Relation of serum total cholesterol, C-reactive protein levels, and statin therapy to survival in heart failure. Am J Cardiol 2006;98:653-658.View Abstract
  • 29.Tsivgoulis G, Spengos K, Karandreas N et al. Presymptomatic neuromuscular disorders disclosed following statin treatment. Arch Intern Med 2006;166:1519-1524.View Abstract
  • 30.Rauramaa R, Halonen P, Vaisanen SB et al. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med 2004;140:1007-1014.View Abstract
  • 31.Cowell SJ, Newby DE, Prescott RJ et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005;352:2389-2397.View Abstract
  • 32.Pedersen TR, Faergeman O, Kastelein JJP et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study, a randomized controlled trial. JAMA 2005;294:2437-2445.
  • 33.Chasman DI, Posada D, Subrahmanyan L et al. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 2004;291:2821-2927.View Abstract
  • 34.Wilke RA, Moore JH, Burmester JK. Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics 2005;15:415-421.View Abstract
  • 35.Krauss RM, Yang H, Rieder MJ et al. Haplotypes in the HMGCoA reductase gene influence plasma LDL level and LDL response to statin in African Americans and Caucasians. Abstract 725. American Heart Association Scientific Sessions 2005. Dallas, Texas; 2005.
  • 36.Sirtori CR, Calabresi L, Ferrara S et al. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr Metab Cardiovasc Dis 2000;10:247-251.View Abstract
  • 37.Montori VM, Farmer A, Wollan PC, Dinneen SF. Fish oil supplementation in type 2 diabetes: a quantitative systematic review. Diabetes Care 2000;23:1407-1415.View Abstract
  • 38.Durrington PN, Bhatnagar D, Mackness MI et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart 2001;85:544-548.View Abstract
  • 39.Chan DC, Watts GF, Barrett PH et al. Effect of atorvastatin and fish oil on plasma high-sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem 2002;48:877-883.View Abstract
  • 40.Chan DC, Watts GF, Barrett PH et al. Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. Diabetes 2002;51:2377-2386.View Abstract
  • 41.Brescia F, Balestra E, Iasella MG, Damato AB. Effects of combined treatment with simvastatin and l-carnitine on triglyceride levels in diabetic patients with hyperlipidaemia. Clin Drug Invest 2002;22:23-28.
  • 42.Derosa G, Cicero AF, Gaddi A et al. The effect of l-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25:1429-1439.View Abstract
  • 43.Solfrizzi V, Capurso C, Colacicco AM et al. Efficacy and tolerability of combined treatment with l-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus. Atherosclerosis 2006;188:455-461.View Abstract
  • 44.Levy HB, Kohlhaas HK. Considerations for supplementing with coenzyme Q10 during statin therapy. Ann Pharmacother 2006;40:290-294.
  • 45.Kerns W 2nd, Kline J, Ford MD. Beta-blocker and calcium channel blocker toxicity. Emerg Med Clin North Am 1994;12:365-390.View Abstract
  • 46.Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82:901-904.View Abstract
  • 47.Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-540.View Abstract
  • 48.Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine. XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol 1977;17:157-164.View Abstract
  • 49.Kishi T, Makino K, Okamoto T et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by coenzyme Q10. In: Yamamura Y, Folkers K, Ito Y, eds. Biochemical and Clinical Aspects of Coenzyme Q. 2 vol. Amsterdam: Elsevier/North Holland Biomedical Press; 1980:139-157.
  • 50.Hamada M, Kazatain Y, Ochi T et al. Correlation between serum CoQ10 level and myocardial contractility in hypertensive patients. In: Folkers K, Yamamura Y, ed. Biomedical and Clinical Aspects of Coenzyme Q. 4 vol. Amsterdam: Elsevier; 1984:263-270.
  • 51.Takahashi N, Iwasaka T, Sugiura T et al. Effect of coenzyme Q10 on hemodynamic response to ocular timolol. J Cardiovasc Pharmacol 1989;14:462-468.View Abstract
  • 52.Lenaz G. Coenzyme Q. New York: Wiley & Sons; 1985.View Abstract
  • 53.Iwamoto Y, Hansen IL, Porter TH, Folkers K. Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by Adriamycin and other quinones having antitumor activity. Biochem Biophys Res Commun 1974;58:633-638.
  • 54.Gaby AR. The role of coenzyme Q10 in clinical medicine. Part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility. Altern Med Rev 1996;1:168-175.
  • 55.Hayek ER, Speakman E, Rehmus E. Acute doxorubicin cardiotoxicity. N Engl J Med 2005;352:2456-2457.View Abstract
  • 56.Brouwer CA, Gietema JA, van den Berg MP et al. Long-term cardiac follow-up in survivors of a malignant bone tumour. Ann Oncol 2006;17:1586-1591.View Abstract
  • 57.Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp Clin Res 1985;11:539-545.View Abstract
  • 58.Domae N, Sawada H, Matsuyama E et al. Cardiomyopathy and other chronic toxic effects induced in rabbits by doxorubicin and possible prevention by coenzyme Q10. Cancer Treat Rep 1981;65:79-91.View Abstract
  • 59.Shinozawa S, Gomita Y, Araki Y. Protective effects of various drugs on Adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice and rats. Biol Pharm Bull 1993;16:1114-1117.
  • 60.Combs AB, Choe JY, Truong DH, Folkers K. Reduction by coenzyme Q10 of the acute toxicity of Adriamycin in mice. Res Commun Chem Pathol Pharmacol 1977;18:565-568.View Abstract
  • 61.Folkers K, Choe JY, Combs AB. Rescue by coenzyme Q10 from electrocardiographic abnormalities caused by the toxicity of Adriamycin in the rat. Proc Natl Acad Sci U S A 1978;75:5178-5180.View Abstract
  • 62.Choe JY, Combs AB, Saji S, Folkers K. Study of the combined and separate administration of doxorubicin and coenzyme Q10 on mouse cardiac enzymes. Res Commun Chem Pathol Pharmacol 1979;24:595-598.View Abstract
  • 63.Choe JY, Combs AB, Folkers K. Prevention by coenzyme Q10 of the electrocardiographic changes induced by Adriamycin in rats. Res Commun Chem Pathol Pharmacol 1979;23:199-202.View Abstract
  • 64.Lubawy WC, Dallam RA, Hurley LH. Protection against anthramycin-induced toxicity in mice by coenzyme Q10. J Natl Cancer Inst 1980;64:105-109.View Abstract
  • 65.Shaeffer J, El-Mahdi AM, Nichols RK. Coenzyme Q10 and Adriamycin toxicity in mice. Res Commun Chem Pathol Pharmacol 1980;29:309-315.View Abstract
  • 66.Usui T, Ishikura H, Izumi Y et al. Possible prevention from the progression of cardiotoxicity in Adriamycin-treated rabbits by coenzyme Q10. Toxicol Lett 1982;12:75-82.View Abstract
  • 67.Shinozawa S, Kawasaki H, Gomita Y. [Effect of biological membrane stabilizing drugs (coenzyme Q10, dextran sulfate and reduced glutathione) on Adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice]. Gan To Kagaku Ryoho 1996;23:93-98.View Abstract
  • 68.Shinozawa S, Gomita Y, Araki Y. Tissue concentration of doxorubicin (Adriamycin) in mouse pretreated with alpha-tocopherol or coenzyme Q10. Acta Med Okayama 1991;45:195-199.View Abstract
  • 69.Neri B, Neri GC, Bandinelli M. Differences between carnitine derivatives and coenzyme Q10 in preventing in vitro doxorubicin-related cardiac damages. Oncology 1988;45:242-246.
  • 70.Ronca-Testoni S, Zucchi R, Ronca F, Bertelli A. Effect of carnitine and coenzyme Q10 on the calcium uptake in heart sarcoplasmic reticulum of rats treated with anthracyclines. Drugs Exp Clin Res 1992;18:437-442.View Abstract
  • 71.Iarussi D, Auricchio U, Agretto A et al. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma. Mol Aspects Med 1994;15 Suppl:s207-s212.View Abstract
  • 72.Folkers K, Langsjoen P, Willis R et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci U S A 1990;87:8931-8934.View Abstract
  • 73.Watts GF, Castelluccio C, Rice-Evans C et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-1057.View Abstract
  • 74.Ghirlanda G, Oradei A, Manto A et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-229.
  • 75.De Pinieux G, Chariot P, Ammi-Said M et al. Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-337.View Abstract
  • 76.Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18 Suppl:S137-S144.
  • 77.Silver MA, Langsjoen PH, Szabo S et al. Statin cardiomyopathy? A potential role for co-enzyme Q10 therapy for statin-induced changes in diastolic LV performance: description of a clinical protocol. Biofactors 2003;18:125-127.View Abstract
  • 78.Passi S, Stancato A, Aleo E et al. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors 2003;18:113-124.
  • 79.Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10: a review of animal and human publications. Biofactors 2003;18:101-111.View Abstract
  • 80.Langsjoen PH, Folkers K, Lyson K et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. Int J Tissue React 1990;12:163-168.View Abstract
  • 81.Manzoli U, Rossi E, Littarru GP et al. Coenzyme Q10 in dilated cardiomyopathy. Int J Tissue React 1990;12:173-178.View Abstract
  • 82.Sinatra ST. Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration. Mol Aspects Med 1997;18 Suppl:S299-S305.View Abstract
  • 82a.Willis RA, Folkers K, Tucker JL, et al. Lovastatin decreases coenzyme Q levels in rats. Proc Natl Acad Sci U S A 1990;87(22)8928-8930.
  • 83.Ichihara K, Satoh K, Yamamoto A, Hoshi K. [Are all HMG-CoA reductase inhibitors protective against ischemic heart disease?]. Nippon Yakurigaku Zasshi 1999;114 Suppl 1:142P-149P.View Abstract
  • 84.Rosenfeldt FL, Pepe S, Linnane A et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann NY Acad Sci 2002;959:355-359; discussion 463-355.View Abstract
  • 85.Laaksonen R, Ojala JP, Tikkanen MJ, Himberg JJ. Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors. Eur J Clin Pharmacol 1994;46:313-317.View Abstract
  • 86.Paloma’ki A, Malminiemi K, Metsa-Ketela T. Enhanced oxidizability of ubiquinol and alpha-tocopherol during lovastatin treatment. FEBS Lett 1997;410:254-258.
  • 87.Paloma’ki A, Malminiemi K, Solakivi T, Malminiemi O. Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo. J Lipid Res 1998;39:1430-1437.
  • 88.Bleske BE, Willis RA, Anthony M et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2.View Abstract
  • 89.Rundek T, Naini A, Sacco R et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-892.View Abstract
  • 90.Yoshida H, Ishikawa T, Ayaori M et al. Effect of low-dose simvastatin on cholesterol levels, oxidative susceptibility, and antioxidant levels of low-density lipoproteins in patients with hypercholesterolemia: a pilot study. Clin Ther 1995;17:379-389.View Abstract
  • 91.Coghlan A. Vitamin E could reduce heart risk. New Scientist 1991;1770:24.
  • 92.Bargossi AM, Battino M, Gaddi A et al. Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Int J Clin Lab Res 1994;24:171-176.
  • 93.Miyake Y, Shouzu A, Nishikawa M et al. Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Arzneimittelforschung 1999;49:324-329.View Abstract
  • 94.Pettit FH, Harper RF, Vilaythong J et al. Reversal of statin toxicity to human lymphocytes in tissue culture. Drug Metab Drug Interact 2003;19:151-160.View Abstract
  • 95.Watts GF, Playford DA, Croft KD et al. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in type II diabetes mellitus. Diabetologia 2002;45:420-426.View Abstract
  • 96.Title LM, Cummings PM, Giddens K et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol 2000;36:758-765.View Abstract
  • 97.White CM. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J Clin Pharmacol 1999;39:111-118.View Abstract
  • 98.Wong B, Lumma WC, Smith AM et al. Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. J Leukoc Biol 2001;69:959-962.View Abstract
  • 99.Brady AJB, Norrie J, Ford I. Statin prescribing: Is the reality meeting the expectations of primary care. Br J Cardiol 2005;12:397-400.
  • 100.Goldman RE, Parker DR, Eaton CB et al. Patients’ perceptions of cholesterol, cardiovascular disease risk, and risk communication strategies. Ann Fam Med 2006;4:205-212.View Abstract
  • 101.Brown MS. Coenzyme Q10 with HMG-CoA reductase inhibitors. Merck and Co (Rahway, NJ); 1990.
  • 102.Tobert JA. Coenzyme Q10 with HMG-CoA reductase inhibitors. Merck and Co (Rahway, NJ); 1990.
  • 103.Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine: prevention by forms of coenzyme Q of the inhibition by Adriamycin of coenzyme Q10-enzymes in mitochondria of the myocardium. Proc Natl Acad Sci U S A 1976;73:4653-4656.View Abstract
  • 104.Singh RB, Niaz MA, Rastogi SS et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-208.View Abstract
  • 105.Hodgson JM, Watts GF, Playford DA et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-1142.View Abstract
  • 106.Glassman AH, Roose SP. Risks of antidepressants in the elderly: tricyclic antidepressants and arrhythmia-revising risks. Gerontology 1994;40 Suppl 1:15-20.View Abstract
  • 107.Scahill L, Lynch KA. Tricyclic antidepressants: cardiac effects and clinical implications. J Child Adolesc Psychiatr Nurs 1994;7:37-39.View Abstract
  • 108.Pinto J, Huang YP, Pelliccione N, Rivlin RS. Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine and amitriptyline upon formation of flavins. Biochem Pharmacol 1982;31:3495-3499.
  • 109.Morton RA. Ubiquinones, plastoquinones and vitamins K. Biol Rev Camb Philos Soc 1971;46:47-96.View Abstract
  • 110.Combs AB, Porter TH, Folkers K. Anticoagulant activity of a naphthoquinone analog of vitamin K and an inhibitor of coenzyme Q10-enzyme systems. Res Commun Chem Pathol Pharmacol 1976;13:109-114.View Abstract
  • 111.Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;344:1372-1373.View Abstract
  • 112.Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-3227.
  • 113.Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-1227; quiz 1228-1230.
  • 113a.Engelsen J, Nielsen JD, Hansen KF. [Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial] Ugeskr Laeger 2003;165(18):1868-71. [Danish]
  • 114.Linder MW. Genetic mechanisms for hypersensitivity and resistance to the anticoagulant warfarin. Clin Chim Acta 2001;308:9-15.View Abstract
  • 115.Aberg F, Appelkvist EL, Broijersen A et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest 1998;28:235-242.View Abstract
  • 116.Kotake C, Ito Y, Yokoyama M, Fukuzaki H. Protective effect of coenzyme Q10 on thyrotoxic heart in rabbits. Heart Vessels 1987;3:84-90.View Abstract
  • 117.Mancini A, De Marinis L, Calabro F et al. Evaluation of metabolic status in amiodarone-induced thyroid disorders: plasma coenzyme Q10 determination. J Endocrinol Invest 1989;12:511-516.View Abstract
  • 118.Portakal O, Inal-Erden M. Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. Clin Biochem 1999;32:461-466.View Abstract
  • 119.Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-506.View Abstract
  • 120.Rosenfeldt FL, Mijch A, McCrystal G et al. Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy. Int J STD AIDS 2005;16:827-829.View Abstract
  • 121.Willis R, Anthony M, Sun L et al. Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status. Biofactors 1999;9:359-363.
  • 122.Kagan VE, Fabisak JP, Tyurina YY. Independent and concerted antioxidant functions of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton, Fla: CRC Press; 2001:119-130.
  • 123.Thomas SR, Stocker R. Mechanisms of antioxidant action of ubiquinol-10 for low-density lipoprotein. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton, Fla: CRC Press; 2001:131-150.
  • 124.Lister RE. An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int Med Res 2002;30:195-199.View Abstract
  • .[No authors listed.] Xenical (orlistat), product prescribing information. Nutley, NJ: Roche Laboratories, Inc; 2000.
  • .[No authors listed.] Product review: co-enzyme Q10. Available at http://www.consumerlab.com. Accessed January 30, 2004.
  • .Albano CB, Muralikrishnan D, Ebadi M. Distribution of coenzyme Q homologues in brain. Neurochem Res 2002;27(5):359-368.
  • .Alcolado JC, Laji K, Gill-Randall R. Maternal transmission of diabetes. Diabet Med 2002;19(2):89-98.
  • .Alho H, Lonnrot K. Coenzyme Q supplementation and longevity. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: molecular mechanisms in health and disease. Boca Raton, FL: CRC Press; 2001:371-380. 
  • .Alsheikh-Ali AA, Ambrose MS, Kuvin JT, et al. The safety of rosuvastatin as used in common clinical practice. a postmarketing analysis. Circulation 2005;111(23):3051-3057.
  • .Arnett DK, Jacobs DR Jr, Luepker RV, et al. Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980-1982 to 2000-2002. Circulation 2005;112:3884-3891.
  • .Artuch R, Colome C, Vilaseca MA, et al. Plasma phenylalanine is associated with decreased serum ubiquinone-10 concentrations in phenylketonuria. J Inherit Metab Dis 2001;24(3):359-366.
  • .Artuch R, Vilaseca MA, Moreno J, et al. Decreased serum ubiquinone-10 concentrations in phenylketonuria. Am J Clin Nutr 1999;70:892-895.
  • .Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure: CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15(Suppl):s287-s294.
  • .Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005;366(9493):1267-1278. Erratum in Lancet 2005;366(9494):1358.
  • .Bairey Merz CN. The treatment of hypercholesterolemia beyond statin therapy: American Heart Association Scientific Sessions 2005. Dallas; AHA; 2005.
  • .Balercia G, Arnaldi G, Lucarelli G, et al. Effects of exogenous CoQ10 administration in patients with idiopathic asthenozoospermia. Int J Andrology 2000;(Suppl 23):43.
  • .Balercia G, Mosca F, Mantero F, et al. Coenzyme q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004;81:93-98.
  • .Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15(Suppl):s187-s193.
  • .Battino M, Giunta S, Galeazzi L, et al. Coenzyme Q10, antioxidant status and ApoE isoforms. Biofactors 2003;18(1-4):299-305.
  • .Battino M, Bompadre S, Leone L, et al. Coenzyme Q, vitamin E and Apo-E alleles in Alzheimer disease. Biofactors 2003;18(1-4):277-281.
  • .Battino M, Bompadre S, Leone L, et al. The effect of Cyclosporine A chronic administration on the antioxidant pattern of rat liver mitochondria: structural and functional consequences. Biofactors 2003;18(1-4):271-275.
  • .Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 2002;36(4):455-460.
  • .Beckman KB, Ames BN. Mitochondrial aging: open questions. Ann N Y Acad Sci 1998;854:118-127.
  • .Belardinelli R, Mucaj A, Lacalaprice F, et al. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J 2006;27(22):2675-2681.
  • .Berthold HK, Unverdorben S, Ralf Degenhardt R, et al. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial. JAMA 2006;295:2262-2269.
  • .Beyer RE. An analysis of the role of coenzyme Q in free radical generation, and as an antioxidant. Biochem Cell Biol 1992;70(6):390-403. (Review)
  • .Beyer RE. The role of ascorbate in antioxidant protection of biomembranes: interaction with vitamin E and coenzyme Q. J Bioenerg Biomembr 1994;26(4):349-358. (Review)
  • .Bianchi A, Salomone S, Caraci F, et al. Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis. Vitam Horm 2004;69:297-312. (Review)
  • .Björnsson E, Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. Hepatology 2005;42(2):481-489.
  • .Blasi MA, Bovina C, Carella G, et al. Does coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration? Ophthalmologica 2001;215(1):51-54.
  • .Block KI. Why integrative therapies? Integr Cancer Ther 2006;5(1):53-56. (Editorial)
  • .Boitier E, Degoul F, Desguerre I, et al. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. J Neurol Sci 1998;156(1):41-46.
  • .Bonetti A, Solito F, Carmosino G, et al. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. J Sports Med Phys Fitness 2000;40(1):51-57.
  • .Bottorff M, Hansten P. Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism: monograph for physicians. Arch Intern Med 2000;160:2273-2280.
  • .Braun B, Clarkson PM, Freedson PS, et al. Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists. Int J Sport Nutr 1991;1(4):353-365.
  • .Bresolin N, Doriguzzi C, Ponzetto C, et al. Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial. J Neurol Sci 1990;100(1-2):70-78.
  • .Britt LD. Coenzyme Q10 confers cardiovascular prevention. Shock 2005;24(6):597.
  • .Bruge F, Tiano L, Cacciamani T, et al. Effect of UV-C mediated oxidative stress in leukemia cell lines and its relation to ubiquinone content. Biofactors 2003;18(1-4):51-63.
  • .Buhmann C, Arlt S, Kontush A, et al. Plasma and CSF markers of oxidative stress are increased in Parkinson’s disease and influenced by antiparkinsonian medication. Neurobiol Dis 2004;15(1):160-170.
  • .Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94(11):1112-1117.
  • .Calabro P, Yeh ET. The pleiotropic effects of statins. Curr Opin Cardiol 2005;20(6):541-546.
  • .Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med April 8, 2004;350(15):1495-1504.
  • .Chagan L, Ioselovich A, Asherova L, et al. Use of alternative pharmacotherapy in management of cardiovascular diseases. Am J Manag Care 2002;8(3):270-288. (Review)
  • .Chalasani N, Aljadhey H, Kesterson J, et al. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology 2004;126(5):1287-1292.
  • .Chan DC, Watts GF, Nguyen MN, et al. Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity. Am J Clin Nutr 2006;84(1):37-43.
  • .Chan DC, Watts GF, Barrett PH, et al. Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. Diabetes 2002;51(8):2377-2386.
  • .Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg 1994;58(5):1427-1432.
  • .Chen RS, Huang CC, Chu NS. Coenzyme Q10 treatment in mitochondrial encephalomyopathies: short-term double-blind, crossover study. Eur Neurol 1997;37(4):212-218.
  • .Chen YF, Lin YT, Wu SC. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. J Thorac Cardiovasc Surg 1994;107(1):242-247.
  • .Chipperfield B. Ubiquinone concentrations in tumours and some normal tissues in man. Nature 1966;209(5029):1207-1209.
  • .Cooper JM, Schapira AH. Friedreich’s ataxia: disease mechanisms, antioxidant and coenzyme Q10 therapy. Biofactors 2003;18(1-4):163-171.
  • .Cowell SJ, Newby DE, Prescott RJ, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005;352(23):2389-2397.
  • .Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20(6):591-598.
  • .Danysz A, Oledzka K, Bukowska-Kiliszek M. Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats. Pol J Pharmacol 1994;46(5):457-461.
  • .Davison GW, Hughes CM, Bell RA. Exercise and mononuclear cell DNA damage: the effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab 2005;15(5):480-492.
  • .de Bustos F, Jimenez-Jimenez FJ, Molina JA, et al. Serum levels of coenzyme Q10 in patients with multiple sclerosis. Acta Neurol Scand 2000;101(3):209-211.
  • .Demirbag R, Yilmaz R, Erel O, et al. The relationship between potency of oxidative stress and severity of dilated cardiomyopathy. Can J Cardiol 2005;21(10):851-855.
  • .Digiesi V, Cantini F, Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Curr Ther Res 1990;47(5):841-845.
  • .Digiesi V, Cantini F, Oradei A, et al. Q10 in essential hypertension. Mol Aspects Med 1994;15(Suppl):s257-s263.
  • .DiMauro S, Gurgel-Giannetti J. The expanding phenotype of mitochondrial myopathy. Curr Opin Neurol 2005;18(5):538-542.
  • .Donchenko HV, Chahovets’ RV. Changes in ubiquinone content of the liver caused by cortisone acetate in normal and vitamin A-deficient rats. Fed Proc Transl Suppl 1965;24(6):983-985.
  • .Dreon DM, Krauss RM. Diet-gene interactions in human lipoprotein metabolism. J Am Coll Nutr 1997;16:313-324.
  • .Duncan AJ, Heales SJ, Mills K, et al. Determination of coenzyme q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme q10 as an internal standard. Clin Chem 2005;51(12):2380-2382.
  • .Eaton S, Skinner R, Hale JP, et al. Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Clin Chim Acta 2000;302(1-2):1-9.
  • .Ebadi M, Govitrapong P, Sharma S, et al. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson’s disease. Biol Signals Recept 2001;10(3-4):224-253. (Review)
  • .Ebadi M, Muralikrishnan D, Pellett LJ, et al. Ubiquinone (coenzyme Q10) and complex I in mitochondrial oxidative disorder of Parkinson’s disease. Proc West Pharmacol Soc 2000;43:55-63. (Review)
  • .Ebadi M, Sharma S, Muralikrishnan D, et al. Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson’s disease. Proc West Pharmacol Soc 2002;45:36-38. (Review)
  • .Engelsen J, Nielsen JD, Hansen KF. [Effect of coenzyme Q10 and ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment: a randomized, double-blind, placebo-controlled cross-over trial.] Ugeskr Laeger 2003;165(18):1868-1871. [Danish]
  • .Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients: a randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87(6):1075-1076.
  • .Eriksson JG, Forsen TJ, Mortensen SA, et al. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors 1999;9(2-4):315-318.
  • .Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1995;1271(1):195-204.
  • .Farnier M, Dejager S, for the French Fluvastatin Study Group. Effect of combined fluvastatin-fenofibrate therapy compared with fenofibrate monotherapy in severe primary hypercholesterolemia. Am J Cardiol 2000;85:53-57.
  • .Ferrante KL, Shefner J, Zhang H, et al. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology 2005;65(11):1834-1836.
  • .Folkers K. Basic chemical research on coeznyme Q10 and integrated clinical research on therapy of diseases. In: G Lenaz, ed. Coenzyme Q. New York: John Wiley and Sons; 1985.
  • .Folkers K, Brown R, Judy WV, et al. Survival of cancer patients on therapy with coenzyme Q10. Biochem Biophys Res Commun 1993;192(1):241-245. (Review)
  • .Folkers K, Drzewoski J, Richardson PC, et al. Bioenergetics in clinical medicine: XVI: reduction of hypertension in patients by therapy with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1981;31(1):129-140.
  • .Folkers K, Kaji M, Baker L, et al. Cardiac outputs of control individuals and cancer patients and evidence of deficiencies of coenzyme Q10 and vitamin B6. Res Commun Chem Pathol Pharmacol 1980;28(1):145-152.
  • .Folkers K, Langsjoen P. Prevention by CoQ10 of life-threatening cardiac dysfunction as a side effect of treatment of hypercholesterolemia by lovastatin in normal medical practice. In: Folkers K, Littarru GP, Yamagami T, Eds. Biochemical and Clinical Aspects of Coenzyme Q, Volume 6. Amsterdam: Elsevier Science 1991:449-452.
  • .Folkers K, Osterborg A, Nylander M, et al. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commun 1997;234(2):296-299.
  • .Folkers K, Shizukuishi S, Takemura K, et al. Increase in levels of IgG in serum of patients treated with coenzyme Q10. Res Commun Pathol Pharmacol 1982;38(2):335-338.
  • .Folkers K, Simonsen R. Two successful double-blind trials with coenzyme Q 10 (vitamin Q 10 ) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta 1995;1271(1):281-286.
  • .Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82(3):901-904.
  • .Folkers K, Wolaniuk J, Simonsen R, et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82:4513-4516.
  • .Foody JM, Shah R, Galusha D, et al. Statins and mortality among elderly patients hospitalized with heart failure. Circulation 2006;113(8):1086-1092.
  • .Fujimoto S, Kurihara N, Hirata K, et al. Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases. Clin Invest 1993;71(8 Suppl):S162-S166.
  • .Fujioka T, Sakamoto Y, Mimura G. Clinical study of cardiac arrhythmias using a 24-hour continuous electrocardiographic recorder (5th report): antiarrhythmic action of coenzyme Q10 in diabetics. Tohoku J Exp Med 1983;141(Suppl):453-463.
  • .Fuke C, Krikorian SA, Couris RR. Coenzyme Q 10: a review of essential functions and clinical trials. U S Pharmacist 2000;25(10):28-41.
  • .Gaby AR. The role of coenzyme Q10 in clinical medicine: part II: cardiovascular disease, hypertension, diabetes mellitus and infertility. Altern Med Rev 1996;1:168-175. (Review)
  • .Garewal HS. Antioxidants and disease prevention. New York: CRC Press; 1997:19-26.
  • .Gazdikova K, Gvozdjakova A, Kucharska J, et al. Effect of coenzyme Q10 in patients with kidney diseases. Cas Lek Cesk 2000;140:307-310.
  • .Getz L, Sigurdsson JA, Hetlevik I, et al. Estimating the high risk group for cardiovascular disease in the Norwegian HUNT 2 population according to the 2003 European guidelines: modelling study. BMJ 2005;331(7516):551.
  • .Glassman AH, Roose SP. Risks of antidepressants in the elderly: tricyclic antidepressants and arrhythmia-revising risks. Gerontology 1994;40(Suppl 1):15-20.
  • .Go AS, Iribarren C, Chandra M, et al. Statin and beta-blocker therapy and the initial presentation of coronary heart disease. Ann Intern Med 2006;144(4):229-238.
  • .Go AS, Lee WY, Yang J, et al. Statin therapy and risks for death and hospitalization in chronic heart failure. JAMA 2006;296 2105-2111.
  • .Goldberg AC, Ostlund RE Jr, Bateman JH, et al. Effect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugs. Am J Cardiol 2006;97(3):376-379.
  • .Goldman RE, Parker DR, Eaton CB, et al. Patients’ perceptions of cholesterol, cardiovascular disease risk, and risk communication strategies. Ann Fam Med 2006;4(3):205-212.
  • .Golomb BA. Implications of statin adverse effects in the elderly. Expert Opin Drug Saf 2005;4(3):389-397.
  • .Golomb BA, Criqui MH, White H, et al. Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry. Arch Intern Med 2004;164(2):153-162. (Review)
  • .Golomb BA, Criqui MH, White HL, et al. The UCSD Statin Study: a randomized controlled trial assessing the impact of statins on selected noncardiac outcomes. Control Clin Trials 2004;25(2):178-202.
  • .Golomb BA, Kane T, Dimsdale JE. Severe irritability associated with statin cholesterol-lowering drugs. QJM 2004;97(4):229-235.
  • .Gorinstein S, Caspi A, Libman I, et al. Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agric Food Chem 2006;54(5):1887-1892.
  • .Gotz ME, Gerstner A, Harth R, et al. Altered redox state of platelet coenzyme Q10 in Parkinson’s disease. J Neural Transm 2000;107(1):41-48.
  • .Graham DJ, Staffa JA, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA 2004;292:2585-2590.
  • .Greenberg SM, Frishman WH. Coenzyme Q10: a new drug for myocardial ischemia? Med Clin North Am 1988;72(1):243-258. (Review)
  • .Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004;44(3):720-732. (Review)
  • .Grundy SM. The issue of statin safety. where do we stand? Circulation 2005. Epub ahead of print. (Editorial)
  • .Gutzmann H, Hadler D. Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study. J Neural Transm Suppl 1998;54:301-310.
  • .Haga SB, Burke W. Using pharmacogenetics to improve drug safety and efficacy. JAMA 2004;291:2869-2871. (Editorial)
  • .Hamada M, Kazatain Y, Ochi T, et al. Correlation between serum CoQ10 level and myocardial contractility in hypertensive patients. In: Folkers K, Yamamura Y, eds. Biomedical and clinical aspects of coenzyme Q. Vol 4. Amsterdam: Elsevier; 1984:263-270.
  • .Hanioka T, Tanaka M, Ojima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med 1994;15(Suppl):s241-s248.
  • .Hanisch F, Zierz S. Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia. Eur J Med Res 2003;8(11):485-491.
  • .Hansen IL, Iwamoto Y, Kishi T, et al. Bioenergetics in clinical medicine: IX: gingival and leucocytic deficiencies of coenzyme Q 10 in patients with periodontal disease. Res Commun Chem Pathol Pharmacol 1976;14(4):729-738.
  • .Hansen KE, Hildebrand JP, Ferguson EE, et al. Outcomes in 45 patients with statin-associated myopathy. Arch Intern Med 2005;165:2671-2676.
  • .Hasegawa G, Yamamoto Y, Zhi JG, et al. Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia. Acta Diabetol 2005;42(4):179-181.
  • .Hata S, Kunida H, Oyama Y. [Antihypertensive effects of coenzyme Q10 in essential hypertension: in relation to the renin-aldosterone system.] Horumon To Rinsho 1977;25(9):1019-1023. [Japanese]
  • .Hayek ER et al. Acute doxorubicin cardiotoxicity. N Engl J Med 2005;352(23):2456-2457.
  • .Heller JH. Disease, the host defense, and Q-10. Perspect Biol Med 1973;16(2):181-187.
  • .Henriksen JE, Andersen CB, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with type 1 diabetes mellitus. Diabet Med 1999;16(4):312-318.
  • .Hodges S, Hertz N, Lockwood K, et al. CoQ10: could it have a role in cancer management? Biofactors 1999;9(2-4):365-370.
  • .Hodgson JM, Watts GF. Can coenzyme Q10 improve vascular function and blood pressure? Potential for effective therapeutic reduction in vascular oxidative stress. Biofactors 2003;18(1-4):129-136.
  • .Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56(11):1137-1142.
  • .Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure: the Q10 Study Group. J Card Fail 1995;1(2):101-107.
  • .Holbrook AM, Pereira JA, Labiris R, et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med 2005;165;1095-1106.
  • .Horvath R, Schneiderat P, Schoser BG, et al. Coenzyme Q10 deficiency and isolated myopathy. Neurology 2006;66(2):253-255.
  • .Hovingh GK, Brownlie A, Bisoendial RJ, et al. A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J Am Coll Cardiol 2004;44(7):1429-1435.
  • .Hsu CH, Cui Z, Mumper RJ, et al. Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors. AAPS PharmSciTech 2003;4(3):E32.
  • .Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology 2001;57(3):397-404.
  • .Ikematsu H, Nakamura K, Harashima S, et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 2006;44(3):212-218.
  • .Imagawa M, Naruse S, Tsuji S, et al. Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer’s disease. Lancet 1992;340:671. (Letter)
  • .Iribarren C, Folsom AR, Jacobs DR Jr, et al. Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis: a case-control study: the ARIC Study Investigators: Atherosclerosis Risk in Communities. Arterioscler Thromb Vasc Biol 1997;17(6):1171-1177.
  • .Iribarren C, Belcher JD, Jacobs DR Jr, et al. Relationship of lipoproteins, apolipoproteins, triglycerides and lipid ratios to plasma total cholesterol in young adults: the CARDIA Study: Coronary Artery Risk Development in Young Adults. J Cardiovasc Risk 1996;3(4):391-396.
  • .Iribarren C, Jacobs DR, Sadler M, et al. Hemorrhagic stroke: is the association confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke 1996;27(11):1993-1998.
  • .Iribarren C, Jacobs DR Jr, Sidney S, et al. Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases. Epidemiol Infect 1998;121(2):335-347.
  • .Iribarren C, Jacobs DR Jr, Sidney S, et al. Serum total cholesterol and risk of hospitalization, and death from respiratory disease. Int J Epidemiol 1997;26(6):1191-1202.
  • .Iribarren C, Jacobs DR Jr, Slattery ML, et al. Epidemiology of low total plasma cholesterol concentration among young adults: the CARDIA study: Coronary Artery Risk Development in Young Adults. Prev Med 1997;26(4):495-507.
  • .Iribarren C, Reed DM, Burchfiel CM, et al. Serum total cholesterol and mortality: confounding factors and risk modification in Japanese-American men. JAMA 1995;273(24):1926-1932.
  • .Iribarren C, Reed DM, Chen R, et al. Low serum cholesterol and mortality: which is the cause and which is the effect? Circulation 1995;92(9):2396-2403.
  • .Iribarren C, Reed DM, Wergowske G, et al. Serum cholesterol level and mortality due to suicide and trauma in the Honolulu Heart Program. Arch Intern Med 1995;155(7):695-700.
  • .Iribarren C, Sharp D, Burchfiel CM, et al. Association of serum total cholesterol with coronary disease and all-cause mortality: multivariate correction for bias due to measurement error. Am J Epidemiol 1996;143(5):463-471.
  • .Ishiyama T, Morita Y, Toyama S, et al. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn Heart J 1976;17(1):32-42.
  • .Istvan ES, Deisenhofer J. Structural mechanisms for statin inhibition of HMG-CoA reductase. Science 2001;292:1160-1164.
  • .Jackson PR, Wallis EJ, Haq IU, et al. Statins for primary prevention: at what coronary risk is safety assured? Br J Clin Pharmacol 2001;52(4):439-446.
  • .Jacobs DR Jr, Hebert B, Schreiner PJ, et al. Reduced cholesterol is associated with recent minor illness: the CARDIA Study: Coronary Artery Risk Development in Young Adults. Am J Epidemiol 1997;146(7):558-564.
  • .Jenkins DJ, Kendall CW, Marchie A, et al. The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metabolism 2003;52(11):1478-1483.
  • .Jimenez-Jimenez FJ, Molina JA, de Bustos F, et al. Serum levels of coenzyme Q10 in patients with Parkinson’s disease. J Neural Transm 2000;107(2):177-181.
  • .Jolliet P, Simon N, Barre J, et al. Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences. Int J Clin Pharmacol Therapeut 1998;36:506-509.
  • .Judy WV, Hall JH, Dugan W, et al. Coenzyme Q10 reduction of Adriamycin® cardiotoxicity. In Folkers K, Yamamura Y, eds. Biomedical and clinical aspects of coenzyme Q. Vol. 4. Amsterdam: Elsevier/North Holland Biomedical Press; 1984:231-241.
  • .Judy WV. Nutritional intervention in cancer prevention and treatment. American College for Advancement in Medicine Spring Conference. Ft Lauderdale, FL, May 3, 1998.
  • .Judy WV, Stogsdill WW, Folkers K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig 1993;71(8 Suppl):S155-S161.
  • .Kagan VE, Fabisak JP, Tyurina YY. Independent and concerted antioxidant functions of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: molecular mechanisms in health and disease. Boca Raton, FL: CRC Press; 2001:119-130.
  • .Kaikkonen J, Tuomainen TP, Nyyssonen K, et al. Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res 2002;36(4):389-397.
  • .Kamei M, Fujita T, Kanbe T, et al. The distribution and content of ubiquinone in foods. Int J Vitam Nutr Res 1986;56(1):57-63.
  • .Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56(4):247-251.
  • .Kaplan RM, Golomb BA. Cost-effectiveness of statin medications. Am Psychol 2001;56(4):366-367.
  • .Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006;114(25):2788-2797.
  • .Kavey R-EW, Allada V, Daniels SR, et al. Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation 2006;114:2710-2738.
  • .Kelly GS. Sport nutrition: a review of selected nutritional supplements for endurance athletes. Altern Med Rev 1997;2:282-295. (Review)
  • .Kelso GF, Porteous CM, Coulter CV, et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 2001;276(7):4588-4596.
  • .Kerns W II, Kline J, Ford MD. Blocker and calcium channel blocker toxicity. Emerg Med Clin North Am 1994;12:2:365-390.
  • .Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med 2000;132:636-640.
  • .Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine: III: inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12(3):533-540.
  • .Kishi T, Kishi H, Watanabe T, et al. Bioenergetics in clinical medicine XI: studies on coenzyme Q and diabetes mellitus. J Med 1976;7(3-4):307-321.
  • .Kishi T, Makino K, Okamoto T, et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by coenzyme Q10. In: Yamamura Y, Folkers K, Ito Y, eds. Biochemical and clinical aspects of coenzyme Q. Vol 2. Amsterdam: Elsevier/North Holland Biomedical Press; 1980:139-157.
  • .Kishi T, Okamoto T, Takahashi T, et al. Cardiostimulatory action of coenzyme Q homologues on cultured myocardial cells and their biochemical mechanisms. Clin Investig 1993;71(8 Suppl):S71-S75.
  • .Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV: inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977;17(1):157-164.
  • .Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine: prevention by forms of coenzyme Q of the inhibition by adriamycin of coenzyme Q10-enzymes in mitochondria of the myocardium. Proc Natl Acad Sci U S A 1976;73(12):4653-4656.
  • .Knopp RH, d’Emden M, Smilde JG, et al. Efficacy and safety of Atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Mellitus (ASPEN). Diabetes Care 2006;29(7):1478-1485.
  • .Koehler CM, Beverly KN, Leverich EP. Redox pathways of the mitochondrion. Antioxid Redox Signal 2006;8(5-6):813-822. (Review)
  • .Kokawa T, Shiota K, Oda K, et al. Coenzyme Q 10 in cancer chemotherapy: experimental studies on augmentation of the effects of masked compounds, especially in the combined chemotherapy with immunopotentiators. Gan To Kagaku Ryoho 1983;10(3):768-774.
  • .Koroshetz WJ, Jenkins BG, Rosen BR, et al. Energy metabolism defects in Huntington’s disease and effects of coenzyme Q10. Ann Neurol 1997;41(2):160-165.
  • .Krauss RM. Atherogenic lipoprotein phenotype and diet-gene interactions. J Nutr 2001;131(2):340S-3S. (Review)
  • .Krauss RM. Dietary and genetic probes of atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol 2005;25(11):2265-2272.
  • .Krauss RM, Siri PW. Metabolic abnormalities: triglyceride and low-density lipoprotein. Endocrinol Metab Clin North Am 2004;33(2):405-415. (Review)
  • .Krauss RM, Yang H, Rieder MJ, et al. Haplotypes in the HMGCoA reductase gene influence plasma LDL level and LDL response to statin in African Americans and Caucasians: American Heart Association Scientific Sessions 2005: Dallas, TX; November 14, 2005. Abstract 725. Circulation Suppl II 2005;112(17):II-135. (Abstract)
  • .Kristiansen IS, Eggen AE, Thelle DS. Cost effectiveness of incremental programmes for lowering serum cholesterol concentration: is individual intervention worth while? BMJ 1991;302(6785):1119-1122.
  • .Kuklinski B, Weissenbacher E, Fahnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspects Med 1994;15(Suppl):s143-s147.
  • .Kwiterovich PO Jr. Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity. Am J Cardiol 2002;90(8A):30i-47i. (Review)
  • .Laaksonen R, Fogelholm M, Himberg JJ, et al. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol Occup Physiol 1995;72(1-2):95-100.
  • .Laaksonen R, Jokelainen K, Laakso J, et al. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am J Cardiol 1996;77(10):851-854.
  • .Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther 1995;57:62-66.
  • .Lalani SR, Vladutiu GD, Plunkett K, et al. Isolated mitochondrial myopathy associated with muscle coenzyme Q10 deficiency. Arch Neurol 2005;62(2):317-320.
  • .Lamperti C, Naini A, Hirano M, et al. Cerebellar ataxia and coenzyme Q10 deficiency. Neurology 2003;60(7):1206-1208.
  • .Lamperti C, Naini AB, Lucchini V, et al. Muscle coenzyme Q10 level in statin-related myopathy. Arch Neurol 2005;62(11):1709-1712.
  • .Lampertico M, Comis S. Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure. Clin Investig 1993;71(8 Suppl):S129-S133.
  • .Lamson DW, Plaza SM. Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment. Altern Med Rev 2002;7(2):94-111.
  • .Langsjoen PH, Folkers K, Lyson K, et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. Int J Tissue React 1990;12(3):163-168.
  • .Langsjoen PH, Langsjoen AM. Overview of the use of CoQ10 in cardiovascular disease. Biofactors 1999;9(2-4):273-284.
  • .Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10: a review of animal and human publications. Biofactors 2003;18(1-4):101-111. (Review)
  • .Langsjoen PH, Langsjoen PH, Folkers K. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. Int J Tissue React 1990;12(3):169-171.
  • .Langsjoen PH, Langsjoen PH, Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ 10 treatment. Clin Investig 1993;71(8 Suppl):S140-S144.
  • .Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65(7):521-523.
  • .Langsjoen H, Langsjoen P, Langsjoen P, et al. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med 1994;15(Suppl):S165-S175.
  • .Langsjoen P, Langsjoen P, Willis R, et al. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;15(Suppl):S265-S272.
  • .Langsjoen PH, Vadhanavikit S, Folkers K. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82(12):4240-4244.
  • .Larsson O. Effects of isoprenoids on growth of normal human mammary epithelial cells and breast cancer cells in vitro. Anticancer Res 1994;114:123-128.
  • .Lerman-Sagie T, Rustin P, Lev D, et al. Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone. J Inherit Metab Dis 2001;24(1):28-34.
  • .Levy HB, Kohlhaas HK. Considerations for supplementing with coenzyme q10 during statin therapy. Ann Pharmacother 2006;40(2):290-294.
  • .Li G, Zou L, Jack CR Jr, et al. Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein. Neurobiol Aging 2006. Epub ahead of print.
  • .Linnane AW, Kopsidas G, Zhang C, et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic Res 2002;36(4):445-453.
  • .Linnane AW, Zhang C, Yarovaya N, et al. Human aging and global function of coenzyme Q10. Ann N Y Acad Sci 2002;959:396-411; discussion 463-465. (Review)
  • .Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care 2005;8(6):641-646. (Review)
  • .Lockwood K, Moesgaard S, Folkers K. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun 1994;199(3):1504-1508.
  • .Lockwood K, Moesgaard S, Hanioka T, et al. Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med 1994;15(Suppl):s231-s240.
  • .Lockwood K, Moesgaard S, Yamamoto T, et al. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 1995;212(1):172-177.
  • .Lonnrot K, Tolvanen JP, Porsti I, et al. Coenzyme Q10 supplementation and recovery from ischemia in senescent rat myocardium. Life Sci 1999;64(5):315-323.
  • .Loop RA, Anthony M, Willis RA, et al. Effects of ethanol, lovastatin and coenzyme Q10 treatment on antioxidants and TBA reactive material in liver of rats. Mol Aspects Med 1994;15(Suppl):s195-s206.
  • .Lubawy WC, Whaley J, Hurley LH. Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice. Res Commun Chem Pathol Pharmacol 1979;24(2):401-404.
  • .Ludwig FC, Elashoff RM, Smith JL, et al. Response of the bone marrow of the vitamin E-deficient rabbit to coenzyme Q and vitamin E. Scand J Haematol 1967;4(4):292-300.
  • .Lynch JW, Everson SA, Kaplan GA, et al. Does low socioeconomic status potentiate the effects of heightened cardiovascular responses to stress on the progression of carotid atherosclerosis? Am J Public Health 1998;88(3):389-394.
  • .Malm C, Svensson M, Ekblom B, et al. Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand 1997;161(3):379-384.
  • .Manuel DG, Kwong K, Tanuseputro P, et al. Effectiveness and efficiency of different guidelines on statin treatment for preventing deaths from coronary heart disease: modelling study. BMJ 2006;332:1419.
  • .Manzoli U, Rossi E, Littarru GP, et al. Coenzyme Q10 in dilated cardiomyopathy. Int J Tissue React 1990;12:173-178.
  • .Mar R, Pajukanta P, Allayee H, et al. Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res 2004;94(7):993-999.
  • .Matsumura T, Saji S, Nakamura R, et al. Evidence for enhanced treatment of periodontal disease by therapy with coenzyme Q. Int J Vitam Nutr Res 1973;43(4):537-548.
  • .Matthews RT, Yang L, Browne S, et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A 1998; 95:8892-8897.
  • .Mattila P, Kumpulainen J. Coenzymes Q9 and Q10: contents in foods and dietary intake. J Food Comp Anal 2001;14(4):409-417. 
  • .Maulik N, Yoshida T, Engelman RM, et al. Dietary coenzyme Q(10) supplement renders swine hearts resistant to ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2000;278(4):H1084-1090.
  • .May HT, Muhlestein JB, Carlquist JF, et al. Relation of serum total cholesterol, C-reactive protein levels, and statin therapy to survival in heart failure. Am J Cardiol 2006;98(5):653-658. Epub 2006.
  • .Mazzola C, Guffanti EE, Vaccarella A, et al. Noninvasive assessment of coenzyme Q10 in patients with chronic stable effort angina and moderate heart failure. Curr Ther Res 1987;41(6):923-932.
  • .McGwin G Jr, Modjarrad K, Hall A, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the presence of age-related macular degeneration in the Cardiovascular Health Study. Arch Ophthalmol 2006;124:33-37.
  • .McDonnell MG, Archbold GP. Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis. Clin Chim Acta 1996;253(1-2):117-126.
  • .Meisinger C, Loewel H, Mraz W, et al. Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study. Eur Heart J 2005;26(3):271-278.
  • .Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors 2003;18(1-4):65-72.
  • .Menke T, Niklowitz P, Reinehr T, et al. Plasma levels of coenzyme Q10 in children with hyperthyroidism. Horm Res 2004;61(4):153-158.
  • .Miles MV, Horn PS, Morrison JA, et al. Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults. Clin Chim Acta 2003;332(1-2):123-132.
  • .Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1992;1126(3):247-254.
  • .Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig 1993;71(8 Suppl):S134-S136.
  • .Mosca F, Fattorini D, Bompadre S, et al. Assay of coenzyme Q(10) in plasma by a single dilution step. Anal Biochem 2002;305(1):49-54.
  • .Moss RW. Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants? Integr Cancer Ther 2006;5(1):3-6.
  • .Mortensen SA. Coenzyme Q10 as an adjunctive therapy in patients with congestive heart failure. J Am Coll Cardiol 2000;36(1):304-305.
  • .Mortensen SA. Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure: rationale, design and end-points of "Q-symbio": a multinational trial. Biofactors 2003;18(1-4):79-89.
  • .Mortensen SA. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Invest 1993;71:S116-S123. (Review)
  • .Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18(Suppl):S137-S144.
  • .Mortensen SA, Vadhanavikit S, Baandrup U, et al. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drug Exp Clin Res 1985;11:581-593.
  • .Mortensen SA, Vadhanavikit S, Muratsu K, et al. Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React 1990;12(3):155-162.
  • .Morton RA. Ubiquinones, plastoquinones and vitamins K. Biol Rev Camb Philos Soc 1971;46:47-96.
  • .Muller T, Buttner T, Gholipour AF, et al. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson’s disease. Neurosci Lett 2003;341(3):201-204.
  • .Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10 treatment in serious heart failure. Biofactors 1999;9(2-4):285-289.
  • .Munnich A, Rotig A, Cormier-Daire V, et al. Clinical presentation of respiratory chain deficiency. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The metabolic and molecular bases of inherited disease. Vol 2. 8th ed. New York: McGraw-Hill; 2001:2261-2274.
  • .Murashige N, Hiroshi I, Matsuo K, et al. Increased incidence of lymphoid malignancies in patients receiving statins (HMG-CoA reductase inhibitors): a case-control study involving 1102 patients. Blood 2002;100:467a.
  • .Musumeci O, Naini A, Slonim AE, et al. Familial cerebellar ataxia with muscle coenzyme Q10 deficiency. Neurology 2001;56(7):849-855.
  • .Nakamura N, Hamazaki T, Ohta M, et al. Joint effects of HMG-CoA reductase inhibitors and eicosapentaenoic acids on serum lipid profile and plasma fatty acid concentrations in patients with hyperlipidemia. Int J Clin Lab Res 1999;29:22-25.
  • .Naini A, Lewis VJ, Hirano M, et al. Primary coenzyme Q10 deficiency and the brain. Biofactors 2003;18(1-4):145-152.
  • .Nicholls SJ, Tuzcu EM, Sipahi I, et al. Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study). Am J Cardiol 2006;97(11):1553-1557.
  • .Niibori K, Yokoyama H, Crestanello JA, et al. Acute administration of liposomal coenzyme Q10 increases myocardial tissue levels and improves tolerance to ischemia reperfusion injury. J Surg Res 1998;79:141-145.
  • .Nielsen AN, Mizuno M, Ratkevicius A, et al. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999;20(3):154-158.
  • .Nissen SE, Tuzcu EM, Schoenhagen P, et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA 2004;291(9):1071-1080.
  • .Nohl H, Gille L. The role of coenzyme Q in lysosomes. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: molecular mechanisms in health and disease. Boca Raton: CRC Press; 2001:99-106.
  • .Nohl H, Staniek K, Kozlov AV, et al. The biomolecule ubiquinone exerts a variety of biological functions. Biofactors 2003;18(1-4):23-31.
  • .Oda T. Effect of coenzyme Q 10 on stress-induced cardiac dysfunction in paediatric patients with mitral valve prolapse: a study by stress echocardiography. Drugs Exp Clin Res 1985;11(8):557-576.
  • .Ogasahara S, Nishikawa Y, Yorifuji S, et al. Treatment of Kearns-Sayre syndrome with coenzyme Q10. Neurology 1986;36(1):45-53.
  • .Ogura F, Morii H, Ohno M, et al. Serum coenzyme Q10 levels in thyroid disorders. Horm Metab Res 1980;12(10):537-540.
  • .Ogura R, Toyama H, Shimada T, et al. The role of ubiquinone (coenzyme Q10) in preventing Adriamycin®-induced mitochondrial disorders in rat heart. J Appl Biochem 1979;1:325.
  • .Okamoto H, Kawaguchi H, Togashi H, et al. Effect of coenzyme Q 10 on structural alterations in the renal membrane of stroke-prone spontaneously hypertensive rats. Biochem Med Metab Biol 1991;45(2):216-226.
  • .Overvad K, Diamant B, Holm L, et al. Coenzyme Q10 in health and disease. Eur J Clin Nutr 1999;53(10):764-770.
  • .Palazzoni G, Pucello D, Littarru GP, et al. Coenzyme Q10 and colorectal neoplasms in aged patients. Rays 1997;22(Suppl 1):73-76.
  • .Pandolfi C, Ferrari D, Stanic I, et al. [Circulating levels of CoQ10 in hypo- and hyperthyroidism.] Minerva Endocrinol 1994;19(3):139-142. [Italian]
  • .Pedersen TR, Faergeman O, Kastelein JJP, et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL Study: a randomized controlled trial. JAMA 2005;294:2437-2445.
  • .Pepping J. Coenzyme Q10. Am J Health Syst Pharm 1999;56(6):519-521. (Review)
  • .Permanetter B, Rossy W, Klein G, et al. Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. Eur Heart J 1992;13(11):1528-1533.
  • .Piorkowski JD Jr. Bayer’s response to "potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis." JAMA 2004;292(21):2655-2659.
  • .Pogessi L, Galanti G, Corneglio M, et al. Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. Curr Ther Res 1991;49:878-886.
  • .Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q 10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33(4):279-284.
  • .Porter DA, Costill DL, Zachwieja JJ, et al. The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men. Int J Sports Med 1995;16(7):421-427.
  • .Psaty BM, Furberg CD, Ray WA, et al. Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis. JAMA 2004;292(21):2622-2631.
  • .Raitakari OT, McCredie RJ, Witting P, et al. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med 2000;28(7):1100-1105.
  • .Rapoport AM, Bigal ME. Migraine preventive therapy: current and emerging treatment options. Neurol Sci 2005;26(Suppl 2):s111-s120. (Review)
  • .Ravnskov U, Rosch PJ, Sutter MC, et al. Should we lower cholesterol as much as possible? BMJ 2006;332(7553):1330-1332. (Letter)
  • .Ridker PM, Cannon CP, Morrow D, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005;352(1):20-28.
  • .Risser N, Murphy M. The promising future of coenzyme q10. Nurse Pract 2005;30(11):66-67.
  • .Rosenfeldt F, Hilton D, Pepe S, et al. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 2003;18(1-4):91-100.
  • .Rosenfeldt FL, Pepe S, Linnane A, et al. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. Biogerontology 2002;3(1-2):37-40.
  • .Rosenfeldt FL, Pepe S, Linnane A, et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann N Y Acad Sci 2002;959:355-359; discussion 463-465.
  • .Rosenhek R. Statins for aortic stenosis. N Engl J Med 2005;352:2441-2443. (Editorial)
  • .Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340(2):115-126.
  • .Rotig A, Appelkvist EL, Geromel V, et al. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Lancet 2000;356(9227):391-395.
  • .Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 2002;22(2):137-141.
  • .Rusciani L, Proietti I, Rusciani A, et al. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol 2006;54(2):234-241.
  • .Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996;335:1001-1009.
  • .Sandor PS, Afra J. Nonpharmacologic treatment of migraine. Curr Pain Headache Rep 2005;9(3):202-205.
  • .Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 2005;64(4):713-715.
  • .Sarter B. Coenzyme Q10 and cardiovascular disease: a review. J Cardiovasc Nurs 2002;16(4):9-20. (Review)
  • .Satoh K, Yamato A, Nakai T, et al. Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on mitochondrial respiration in ischaemic dog hearts. Br J Pharmacol 1995;116:1894-1898.
  • .Schilling G, Coonfield ML, Ross CA, et al. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington’s disease transgenic mouse model. Neurosci Lett 2001;315(3):149-153.
  • .Schmermund A, Achenbach S, Budde T, et al. Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months. a multicenter, randomized, double-blind trial. Circulation 2006;113:427-437.
  • .Shults CW, Beal MF, Fontaine D, et al. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 1998;50(3):793-795.
  • .Scott GN, Elmer GW. Update on natural product-drug interactions. Am J Health-Syst Pharm 2002;59(4):339-347.
  • .Sharma SK, Ebadi M. Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxid Redox Signal 2003;5(3):251-264.
  • .Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial: PRO-spective Study of Pravastatin in the Elderly at Risk. Lancet 2002;360:1623-1630.
  • .Shigeta Y, Izumi K, Abe H. Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetics. J Vitaminol 1966;12:293-298.
  • .Shils ME, Olson JA, Shike M, et al. Modern nutrition in health and disease. 9th ed. Baltimore: Williams & Wilkins; 1999:90-92, 1377-1378.
  • .Shoffner JM. Oxidative phosphorylation diseases. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The metabolic and molecular bases of inherited disease. Vol 2. 8th ed. New York: McGraw-Hill; 2001:2367-2392.
  • .Shults CW, Beal MF, Fontaine D, et al. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 1998;50(3):793-795.
  • .Shults CW, Haas RH, Beal MF. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson’s disease. Biofactors 1999;9(2-4):267-272.
  • .Shults CW, Haas RH, Passov D, et al. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 1997;42(2):261-264.
  • .Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59(10):1541-1550.
  • .Sikorska M, Borowy-Borowski H, Zurakowski B, et al. Derivatised alpha-tocopherol as a CoQ10 carrier in a novel water-soluble formulation. Biofactors 2003;18(1-4):173-183.
  • .Silver MA, Langsjoen PH, Szabo S, et al. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q(10) to reverse that dysfunction. Am J Cardiol 2004;94(10):1306-1310.
  • .Silver MA, Langsjoen PH, Szabo S, et al A. Statin cardiomyopathy? A potential role for co-enzyme Q10 therapy for statin-induced changes in diastolic LV performance: description of a clinical protocol. Biofactors 2003;18(1-4):125-127.
  • .Simkovic M, Frerman FE. Alternative quinone substrates and inhibitors of human electron-transfer flavoprotein-ubiquinone oxidoreductase. Biochem J 2004;378(Pt 2):633-640.
  • .Sinatra DS, Sinatra ST, Heyser CJ. The effects of coenzyme Q10 on locomotor and behavioral activity in young and aged C57BL/6 mice. Biofactors 2003;18(1-4):283-287.
  • .Sinatra ST. Alternative medicine for the conventional cardiologist. Heart Dis 2000;2(1):16-30. (Review)
  • .Sinatra ST. "Care," cancer and coenzyme Q10. J Am Coll Cardiol 1999;33(3):897-899. (Letter; Comment)
  • .Sinatra ST. Coenzyme Q10 and congestive heart failure. Ann Intern Med 2000;133(9):745-746. (Letter)
  • .Sinatra ST. Coenzyme Q10: a vital therapeutic nutrient for the heart with special application in congestive heart failure. Conn Med 1997;61(11):707-711.
  • .Sinatra ST. Is cholesterol lowering with statins the gold standard for treating patients with cardiovascular risk and disease? South Med J 2003;96(3):220-222. (Editorial)
  • .Sinatra ST. Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration. Mol Aspects Med 1997;18(Suppl):S299-S305.
  • .Sinatra ST, DeMarco J. Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage. Conn Med 1995;59(10):579-588. (Review)
  • .Singh RB, Khanna HK, Niaz MA. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in chronic renal failure: discovery of a new role. J Nutr Environ Med 2000;10:281-288.
  • .Singh RB, Kumar A, Niaz MA, et al. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in patients with end-stage renal failure. J Nutr Environ Med 2003;13(1):13-22.
  • .Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13(3):203-208.
  • .Singh RB, Singh MM. Effect of coenzyme Q10 in new indications with antioxidant vitamin deficiency. J Nutr Environ Med 1999;9:223-228.
  • .Singh RB, Wander GS, Rastogi A, et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 1998;12(4):347-353.
  • .Siri PW, Krauss RM. Influence of dietary carbohydrate and fat on LDL and HDL particle distributions. Curr Atheroscler Rep 2005;7(6):455-459.
  • .Sirtori CR, Calabresi L. Japan: are statins still good for everybody? Lancet 2006;368(9542):1135-1136.
  • .Sobreira C, Hirano M, Shanske S, et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology 1997;48(5):1238-1243.
  • .Soderberg M, Edlund C, Kristensson K, et al. Lipid compositions of different regions of the human brain during aging. J Neurochem 1990;54(2):415-423.
  • .Soja AM, Mortensen SA. [Treatment of chronic cardiac insufficiency with coenzyme Q10, results of meta-analysis in controlled clinical trials.] Ugeskr Laeger 1997;159(49):7302-7308.
  • .Stange KC, Acheson LS. Communication in the era of ‘personalized’ medicine. Ann Fam Med 2006;4(3):194-196. (Editorial)
  • .Stricker RB, Goldberg B. Is cholesterol lowering with statins the gold standard for treating patients with cardiovascular risk and disease? South Med J 2003;96(8):837-838. (Letter)
  • .Strom BL. Potential for conflict of interest in the evaluation of suspected adverse drug reactions: a counterpoint. JAMA 2004;292(21):2643-2646.
  • .Sunamori M, Tanaka H, Maruyama T, et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovasc Drugs Ther 1991;5(Suppl 2):297-300.
  • .Suzuki S, Hinokio Y, Ohtomo M, et al. The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation. Diabetologia 1998;41(5):584-588.
  • .Svensson M, Malm C, Tonkonogi M, et al. Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise. Int J Sport Nutr 1999;9(2):166-180.
  • .Taggart DP, Jenkins M, Hooper J, et al. Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations. Ann Thorac Surg 1996;61(3):829-833.
  • .Tanaka J, Tominaga R, Yoshitoshi M, et al. Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement. Ann Thorac Surg 1982;33(2):145-151.
  • .Tarnopolsky MA, Raha S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med Sci Sports Exerc 2005;37(12):2086-2093.
  • .Thavendiranathan P, Bagai A, Brookhart MA, et al. Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:2307-2313.
  • .Thomas SR, Leichtweis SB, Pettersson K, et al. Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol 2001;21(4):585-593.
  • .Thomas SR, Neuzil J, Stocker R. Inhibition of LDL oxidation by ubiquinol-10: a protective mechanism for coenzyme Q in atherogenesis? Mol Aspects Med 1997;18:S85-S103.
  • .Thomas SR, Stocker R. Mechanisms of antioxidant action of ubiquinol-10 for low-density lipoprotein. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: molecular mechanisms in health and disease. Boca Raton, FL: CRC Press; 2001:131-150.
  • .Thorsteindottir B, Rafnsdottir S, Geirsson AJ, et al. No difference in ubiquinone concentration of muscles and blood in fibromyalgia patients and healthy controls. Clin Exp Rheumatol 1998;16:513-514.
  • .Topol EJ. Intensive statin therapy: a sea change in cardiovascular prevention. N Engl J Med 2004;350(15):1562-1564. (Editorial)
  • .Tran MT, Mitchell TM, Kennedy DT, et al. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy 2001;21(7):797-806.
  • .Trupp RJ, Abraham WT. Congestive heart failure. In: Rakel RE, Bope ET, eds. Rakel: Conn’s current therapy 2002. 54th ed. New York: Saunders Company; 2002:306-313.
  • .Tsivgoulis G, Spengos K, Karandreas N, et al. Presymptomatic neuromuscular disorders disclosed following statin treatment. Arch Intern Med 2006;166:1519-1524.
  • .Turunen M, Wehlin L, Sjoberg M, et al. beta2-Integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10. Biochem Biophys Res Commun 2002;296(2):255-260.
  • .van der Steeg WA, Kuivenhoven JA, Klerkx AH, et al. Role of CETP inhibitors in the treatment of dyslipidemia. Curr Opin Lipidol 2004;15(6):631-636. (Review)
  • .van Gaal L, Folkers K, Yamamura Y, eds. Exploratory study of coenzyme Q 10. In: Obesity, biomedical and clinical aspects of coenzyme Q. Vol 4. Amsterdam: Elsevier Science Publications; 1984:369-373.
  • .Virmani A, Gaetani F, Binienda Z. Effects of metabolic modifiers such as carnitines, coenzyme Q10, and PUFAs against different forms of neurotoxic insults: metabolic inhibitors, MPTP, and methamphetamine. Ann N Y Acad Sci 2005;1053:183-191.
  • .Walldius G, Jungner I. Rationale for using apolipoprotein B and apolipoprotein A-I as indicators of cardiac risk and as targets for lipid-lowering therapy. Eur Heart J 2005;26(3):210-212. (Editorial)
  • .Wang D, Taylor, KD, Smith J, et al. IL1B and TRAF6 are associated with components of low-density lipoprotein cholesterol reduction during statin therapy. Poster 3. American Heart Association Scientific Sessions 2005. Dallas, Nov 14, 2005.
  • .Wang QF, Liu X, O’Connell J, et al. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons. Hum Mol Genet 2004;13(10):1049-1056.
  • .Wang TJ, Gona P, Larson MG, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 2006;355(25):2631-2639.
  • .Ware JH. The limitations of risk factors as diagnostic tools. N Engl J Med 2006;355(25):2615-2617. (Editorial)
  • .Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 1999;33:1549-1552.
  • .Watts GF, Cummings MH, Umpleby M, et al. Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: pathophysiological and therapeutic implications. Eur J Clin Invest 1995;25:559-567.
  • .Watts GF, Playford DA, Croft KD, et al. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in type II diabetes mellitus. Diabetologia 2002;45(3):420-426.
  • .Watts TL. Coenzyme Q10 and periodontal treatment: is there any beneficial effect? Br Dent J 1995;178(6):209-213.
  • .Weber C. Dietaty intake and absorption of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: molecular mechanisms in health and disease. Boca Raton, FL: CRC Press; 2001:209-215.
  • .Weber C, Jakobsen TS, Mortensen SA, et al. Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Int J Vitam Nutr Res 1994;64:311-315.
  • .Wei L, Murphy MJ, MacDonald TM. Impact on cardiovascular events of increasing high density lipoprotein cholesterol with and without lipid lowering drugs. Heart 2006;92(6):746-751.
  • .Weiss M. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med 1994;15(Suppl):S273-S280.
  • .Werbach MR. Foundations of nutritional medicine. Tarzana, CA: Third Line Press; 1997. (Review)
  • .Werbach MR. Nutritional influences on illness. 2nd ed. Tarzana, CA: Third Line Press; 1993:66, 119, 122, 179, 421. (Review)
  • .Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 2000;5(2):93-108.
  • .Weston SB, Zhou S, Weatherby RP, et al. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997;7(3):197-206.
  • .Wilke RA, Moore JH, Burmester JK. Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics 2005;15(6):415-421.
  • .Wilkinson EG, Arnold RM, Folkers K, et al. Bioenergetics in clinical medicine: II: adjunctive treatment with coenzyme Q in periodontal therapy. Res Commun Chem Pathol Pharmacol 1975;12(1):111-123.
  • .Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine: VI: adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1976;14(4):715-719.
  • .Willis R, Anthony M, Sun L, et al. Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status. Biofactors 1999;9(2-4):359-363.
  • .Willis RA, Folkers K, Tucker JL, et al. Lovastatin decreases coenzyme Q levels in rats. Proc Natl Acad Sci U S A 1990;87(22):8928-8930.
  • .Witte KKA, Nikitin NP, Parker AC, et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005;26:2238-2244.
  • .Witting PK, Pettersson K, Letters J, et al. Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Free Radic Biol Med 2000;29(3-4):295-305.
  • .Wold LE, Muralikrishnan D, Albano CB, et al. Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q9 and Q10. Acta Diabetol 2003;40(2):85-90.
  • .Yamagami T, Iwamoto Y, Folkers K. Deficiency of activity of succinate dehydrogenase-coenzyme Q10 reductase in leucoytes from patients with essential hypertension. Int J Vitam Nutr Res 1974;44(3):404-414.
  • .Yamagami T, Shibata N, Folkers K. Bioenergetics in clinical medicine: VIII: administration of coenzyme Q10 to patients with essential hypertension. Res Commun Chem Pathol Pharmacol 1976;14(4):721-727.
  • .Yamagami T, Shibata N, Folkers K. Bioenergetics in clinical medicine: studies on coenzyme Q10 and essential hypertension. Res Commun Chem Pathol Pharmacol 1975;11(2):273-288.
  • .Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension: a double-blind controlled study. In: Folkers K, Yamamura Y, eds. Biomedical and clinical aspects on coenzyme Q. Amsterdam: Elsevier; 1986:337-343.
  • .Yan J, Fujii K, Yao J, et al. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol 2006;41(2):130-140.
  • .Yeshurun D, Slobodin G, Keren D, et al. Statin escape phenomenon: does it really exist? Eur J Intern Med 2005;16(3):192-194.
  • .Yikoski T, Piirainen J, Hanninen O, et al. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med 1997;18(Suppl):s283-s290.
  • .Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid (EPA) on major cardiovascular events in hypercholesterolemic patients: the Japan EPA Lipid Intervention Study (JELIS). American Heart Association Scientific Sessions 2005. Dallas, Nov 14, 2005.
  • .Young AJ, Johnson S, Steffens DC, et al. Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr 2007;12(1):62-68. (Review)
  • .Zhou Q, Chan E. Accuracy of repeated blood sampling in rats: a new technique applied in pharmacokinetic/pharmacodynamic studies of the interaction between warfarin and co-enzyme Q10. J Pharmacol Toxicol Methods 1998;40(4):191-199.
  • .Zhou S, Chan E. Effect of ubidecarenone on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. Drug Metabol Drug Interact 2001;18(2):99-122.
  • .Zhou M, Zhi Q, Tang Y, et al. Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. J Cardiovasc Surg (Torino) 1999;40(3):355-361.
  • .Zita C, Overvad K, Mortensen SA, et al. Serum coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomised controlled study. Biofactors 2003;18(1-4):185-193.