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Vitamin D (Calciferol)
Nutrient Names: Vitamin D, calciferol.
Synonyms: 1,25-Dihydroxyvitamin D, calciferol, calcipotriol, cholecalciferol (vitamin D3), ergocalciferol (vitamin D2), irradiated ergocalciferol, ergosterol (provitamin D2), activated/irradiated ergosterol (vitamin D2).
Related Substance: Calcitriol is also the name of a drug that is the active (1,25-dihydroxycholecalciferol) form of vitamin D.
Chemistry and Forms
Vitamin D is the generic term for compounds that exhibit the biological activity of calciferol: vitamin D
Physiology and Function
Vitamin D functions as both a fat-soluble vitamin and a hormone. From dietary sources, vitamin D is absorbed from the small intestine in the presence of bile and is transported into the circulation via the lymph in chylomicrons (similar to vitamin A transport). Vitamin D can also be synthesized in the skin as a result of direct exposure to the ultraviolet light in sunlight (UVB radiation) through the conversion of 7-dehydrocholesterol to cholecalciferol (vitamin D
Calcitriol binds to the vitamin D receptor (VDR), a nuclear transcription factor that regulates gene expression. When the calcitriol/VDR complex subsequently combines with the retinoic acid X receptor (RXR), the resulting VDR/RXR heterodimer can interact with the vitamin D–responsive elements (VDREs) within the DNA. This interaction between the VDR/RXR heterodimer and a VDRE alters the rate of transcription of a related gene and thereby regulates the activity of vitamin D–dependent calcium transporters in the small intestine, osteoblasts in bone, and the 1-hydroxylase enzyme in the kidneys. Defects in the vitamin D receptor lead to hypocalcemic vitamin D–resistant rickets, congenital total lipodystrophy, and persistent müllerian duct syndrome. Research suggests that bone may be more responsive to exercise in some genotypes of VDR than in others, 1 and that gene-environment interactions such as leisure physical activity and VDR genotype may play a role in maintaining the bone mineral density (BMD) at the lumbar spine in active postmenopausal women, especially in older active women. 2
The vitamin D endocrine system is responsible for maintaining tight regulation of serum calcium levels within the narrow range critical to bone metabolism and healthy functioning of the nervous system. Calcitriol mediates the intestinal absorption and blood levels of calcium and phosphorus. It facilitates mineral deposition into bone, modulates bone mineralization and demineralization, and enhances muscle strength and balance. Vitamin D is necessary to calcium absorption and increases the absorption of calcium from the intestine (by stimulating the synthesis of calcium-binding protein and the epithelial calcium channel) and maintains serum calcium levels in the normal range; thus increasing resorption of calcium from bone as well as facilitating calcium storage in the bones. Consequently, even though it initially causes bone resorption, the net effect is to increase calcium deposition in the bone. In addition to promoting calcium absorption, calcitriol mediates the intestinal absorption of phosphorus, possibly magnesium and zinc as well, and may promote renal tubule phosphate resorption. Vitamin D is stored in body fat.
Vitamin D also plays many important roles in hormonal regulation and immune function. It helps maintain adequate blood levels of insulin and may assist the metabolism of sugar. Vitamin D may also assist healthy thyroid function, and the active form of vitamin D
Known or Potential Therapeutic Uses
Vitamin D is used to prevent osteoporosis and osteoporotic fractures, and intake is associated with reduced risk of breast cancer, colorectal cancer, prostate cancer, as well as cancers of the lung, skin (melanoma), colon, and bone. Administration of vitamin D in conjunction with bisphosphonate therapy (e.g., alendronate, risedronate, or etidronate) or exogenous hormone therapy (e.g., HRT) may enhance clinical outcomes in preventing and treating osteoporosis. A range of autoimmune diseases, particularly type 1 diabetes mellitus, rheumatoid arthritis, and multiple sclerosis, may be responsive to integrative therapeutics employing vitamin D, especially when they involve a VDR gene polymorphism. Calcitriol, the active metabolite of vitamin D, has been found to inhibit the growth of human prostate cancer cells in vitro; however, findings from preliminary human trials have been disappointing for its use (or that of analogs) as part of innovative protocols in the treatment of hormone-refractory prostate cancer.
Historical/Ethnomedicine Precedent
The physiological parameters of vitamin D may be premised on the ancient origins of humans in equatorial Africa. The high level of exposure to sun inherent to such an interaction with the environment may play a fundamental role in the high susceptibility for insufficiency or deficiency among modern humans less exposed to the sun, especially for dark-skinned individuals, because melanin acts as an ultraviolet absorber.
Possible Uses
Atherosclerosis, autoimmune diseases, breast cancer, burns, cancer prevention, celiac disease, digestive system cancers (oral, esophageal, stomach, pancreas, colorectal; risk reduction, especially in individuals with dark skin), Crohn's disease, depression (particularly seasonal affective disorder), diabetes mellitus, epilepsy, falls (prevention, especially in the elderly), fractures (especially in the elderly), hearing loss, hyperparathyroidism (secondary), hypertension, hypoparathyroidism, migraine headaches, multiple sclerosis, obesity, osteoarthritis, osteomalacia, osteoporosis, prevention of vitamin D deficiency, prostate cancer, psoriasis, rheumatoid arthritis (risk reduction), rickets, scleroderma, skin cancer (risk reduction), tuberculosis.
Deficiency Symptoms
Rickets, osteomalacia, osteoporosis, and fracture risk remain the most obvious and well-known outcomes associated with vitamin D deficiency. Researchers have increasingly expressed concern that the low levels of vitamin D found in a large percentage of Americans and Europeans may be associated with increased risk of a range of conditions, including cancer, heart disease, hypertension, diabetes, multiple sclerosis, and diminished immune status. The classic groups known for increased risk of deficiency are breast-fed infants, individuals on vegetarian diets, the elderly, individuals with fat malabsorption or chronic kidney disease, and individuals with compromised sun exposure due to lifestyle, climate, season, or cultural practices. Other significant etiologies include alcoholism, burns (and burn scarring), Crohn's disease, Cushing's disease, dark skin, decreased consumption of vitamin D, hypothyroidism, anticonvulsant drug therapy, kidney or liver disease, malabsorption (as in celiac disease or after intestinal surgery), ulcerative colitis, and vitamin D–resistant rickets. Vitamin D receptor polymorphic alleles have been linked to diabetes mellitus and colon cancer. 3,4Low dietary calcium intake may enhance the phenotypic expression of VDR gene polymorphisms. 5
Awareness of previously unrecognized vitamin D deficiency and its implications in long-term pathological processes has been growing in recent years. 6,7Chapuy et al. 8 (1997) reported that one of seven adults may be deficient in vitamin D. Similarly, a study in 1998 by Thomas et al. 9 found that 37% of the total group surveyed were deficient in vitamin D, even though their reported diets should have provided the currently recommended levels of vitamin. This study also found that 42% of hospitalized patients under age 65 were deficient in vitamin D. Overall, vitamin D inadequacy has been reported in up to 57% of general medicine inpatients in the United States. 10 Spanish researchers found that healthy postmenopausal women in modern societies have an extremely high prevalence of vitamin D deficiency. 11 Likewise, young adults exhibit an unexpectedly high incidence of vitamin D insufficiency. 12 Vitamin D deficiencies may also raise the risk of prostate cancer by disrupting the relationship between androgens and VDR in prostate cells. 13
Dietary Sources
Cod liver oil, oily cold-water fish (salmon, mackerel, herring), butter, egg yolks, vitamin D–fortified milk, and orange juice.
Most vitamin D in humans is derived from endogenous synthesis subsequent to sun exposure rather than from dietary sources. Vitamin D is found primarily in foods of animal origin, unless they are fortified. Cod liver oil is considered an excellent dietary source. Vegetables are usually low in vitamin D, although mushrooms, if irradiated, can be a significant source of vitamin D. Milk used to make cheese or yogurt is usually not fortified with vitamin D. Human milk contains the 25-hydroxycholecalciferol form of D, possibly to compensate for the limited ability of the liver in infants to achieve the first hydroxylation of cholecalciferol. The vitamin D content in human milk varies with maternal sun exposure and vitamin D intake.
Sunshine
With exposure to ultraviolet light, the skin synthesizes vitamin D. It is estimated that 20 minutes, with face and arms exposed, will stimulate about 600 to 1000 IU per day, during spring, summer, and fall in temperate regions, and year-round in tropical and subtropical regions. Enough sun or UVB exposure to produce minimal skin erythema (known as the minimal erythemic dose ) can produce 10,000 to 20,000 IU in about an hour. Adequate amounts of vitamin D can theoretically be synthesized and stored in fat to carry an individual through the winter. In temperate latitudes, above 35° to 50°, a minimum of 15 minutes of sun exposure on the arms, face, and hands three times per week in the morning or late afternoon during the spring, summer, and fall is needed to avoid vitamin D deficiency at the end of winter. However, research indicates that, in actuality, many individuals in higher latitudes, especially with seasonal clothing, overcast climates, and minimal time outdoors, do not receive adequate sun exposure to avoid compromised vitamin D status. Sun exposure with sunscreen significantly prevents skin synthesis of vitamin D.
Dosage Forms Available
Capsules, injection (IM), liquid, tablets. Intramuscular (IM) form is not available in the United States.
Oral dosing (with meals) is preferred, but malabsorption associated with gastrointestinal, liver, or biliary disease may necessitate IM injection.
Nutrient Preparations Available
Cholecalciferol (vitamin D
Dosage Range
Adult
Dietary: The adequate intake of vitamin D (cholecalciferol, or vitamin D
Supplemental/Maintenance: 10 µg (400 IU) per day. However, in some cases this may be unnecessary, given consistent adequate direct exposure to the sun, usually 20 minutes per day. Supplement with cod liver oil if 25(OH)D levels are low (1 tsp per 50 pounds of body weight). One tablespoon of cod liver oil provides approximately 1200 IU (30 µg) of vitamin D
A dose of 20 µg (800 IU) per day for individuals, especially the elderly, not adequately exposed to sunlight or living in farther northern or southern latitudes.
Pharmacological/Therapeutic: 800 to 2000 IU per day, including dietary sources, under supervision of a physician or health care professional experienced in nutritional therapeutics. 14,15Dosages used in clinical studies range from 5 µg (200 IU) to 250 µg (10,000 IU) daily. Significantly higher doses are often used in the treatment of secondary hypoparathyroidism, vitamin D–resistant rickets, nutritional rickets and osteomalacia, and familial hypophosphatemia.
Toxic: The current official tolerable upper intake level (UL) is 50 µg (2000 IU) per day. However, many experts in the field strongly support raising the UL to at least 4000 IU, and 10,000 IU may be tolerable for most individuals, but such a daily dose should be medically monitored.
Adverse effects have been reported at concentrations ranging from 250 to 1250 µg (10,000-50,000 IU) per day.
Pediatric (<18 years)
Dietary: The adequate intake (AI) of vitamin D (cholecalciferol, or vitamin D
Supplemental/Maintenance: One teaspoon of cod liver oil per 50 lb/wt. Sun exposure of 20 minutes daily is adequate and preferable. Do not give cod liver oil when sun exposure is being implemented.
Pharmacological/Therapeutic
- Premature infants: 10 to 20 µg (400-800 units) per day, up to 750 µg (30,000 IU) per day.
- Infants and healthy children: 10 µg (400 IU) per day.
Significantly higher doses are often used in the treatment of hypoparathyroidism, nutritional rickets and osteomalacia, vitamin D–resistant rickets, and familial hypophosphatemia. Vitamin D receptor defects, specifically tissue resistance to vitamin D, or vitamin D–dependent rickets (VDDR), are usually treated with 20 µg/day of the bioactive form, calcitriol, or 5 mg/day of the dietary form, vitamin D
Toxic: UL for infants (0-12 months) is 25 µg (1000 IU) per day and for children (1-18 years) is 50 µg (2000 IU) per day.
Note: Requirements depend on the exposure of a person's skin to ultraviolet radiation. The intensity of exposure is also a factor. The latitude determines how much exposure to sunlight the person requires to synthesize adequate levels of vitamin D. Pollution, clouds, and skin color also affect an individual's ability to produce vitamin D. The darker the skin, the less vitamin D will be produced (up to 95% blocked). However, with longer exposure times, even with the darkest skin color, sufficient levels of vitamin D are produced. Glass and topical sunscreens block UV light.
Laboratory Values
Laboratory assessment of vitamin D status has been in a state of controversy and evolution in recent years, particularly since the effects of mild vitamin D deficiency or insufficiency have become more widely recognized.
Plasma 25(OH)-Vitamin D
This assay reflects body reserves. Plasma levels less than 25 nmol/L indicate deficiency.
However, results from laboratories doing 25-hydroxyvitamin D (25-OHD) tests vary widely. 17 Reference ranges from most labs are too low. Optimal serum levels of 25-OHD to avoid increases in PTH are at least 20 ng/mL, 18 but may actually be in the range of 45 to 55 ng/mL (115-140 nmol/L). Heaney et al. 19,20suggest that the appropriate serum 25-OHD level is 32 ng/mL. 8 Concurrent parathyroid tests (PTH) may elucidate equivocal laboratory findings because one could expect a high PTH if there is a low vitamin D concentration in the blood.
Plasma 1,25(OH)2 -Vitamin D
This assay measures the active form of the vitamin. As 25-OHD levels drop, PTH secretion increases (secondary hyperparathyroidism), which maintains the 1,25(OH)
Also, measure serum calcium, blood urea nitrogen (BUN), and phosphorus every 1 to 2 weeks; and monitor bone density regularly until stabilized.
Serum calcium concentration times phosphorus concentration should not exceed 70 mg/dL to avoid ectopic calcification; ergocalciferol levels: 10 to 60 ng/mL; serum calcium: 9 to 10 mg/dL; phosphorus: 2.5 to 5.0 mg/dL.
Overview
Vitamin D is generally well tolerated, and excessive doses from sunlight exposure or dietary source are considered highly improbable, if not impossible. Its UL of 50 µg (2000 IU) per day reflects that vitamin D has long been considered the most likely of all vitamin supplements to cause toxicity. Although a revised consensus has developed in recent years among researchers and some clinicians, regulatory and institutional guidelines are only gradually beginning to respond to and integrate the new data into their recommendations.
Adverse effects have been reported at concentrations ranging from 250 to 1250 µg/daily. 21 Hypervitaminosis D has generally been associated with intake of 625 to 1500 µg (25,000-60,000 IU) daily for 1 to 4 months, or several years of vitamin D supplementation at 250 to 1250 µg (10,000-50,000 IU) daily, and has never been associated with sun exposure. Published case reports of vitamin D toxicity with hypercalcemia, for which the 25(OH)D concentration and vitamin D dose are known, all involve intake of at least 1000 µg (40,000 IU) per day, and only one case occurred at a level of intake under 40,000 IU/day. 14
However, emerging evidence and the opinions of many vitamin D researchers now suggest that the daily value (DV) of 400 IU for vitamin D, which was based on the amount necessary to prevent rickets in infants (initially given as 5 mL of cod liver oil 100 years ago) is an order of magnitude below the amount necessary for older adults, and those not exposed to sun without sunscreen on a regular basis, to achieve and maintain blood levels of vitamin D that are optimum for bone health and cancer prevention. 15,22-33“Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 IU/d (65 mcg/d) of oral vitamin D
Nutrient Adverse Effects
General Adverse Effects
Excessive levels of vitamin D intake over an extended period can lead to headaches, kidney stones, and weight loss. Less common symptoms include diarrhea, increased thirst, increased urination, irritability, and failure to gain weight in children. More extreme consequences include blindness, deafness, and potentially death. Elevated vitamin D levels (as well as vitamin D deficiency) may be related to increased risk of prostate cancer. 35 Vitamin D intake increases both calcium and phosphorus absorption. Although the increased levels of calcium associated with enhanced vitamin D status may be an indicator of benefit for those at risk for bone loss, elevated blood levels of calcium may also be associated with increased risk of heart disease. Elevated serum calcium levels induced by hypervitaminosis D are responsible for many of its primary adverse effects.
Acute overdose is associated with increased urinary frequency, nausea, vomiting, loss of appetite, diarrhea, muscle weakness, dizziness, and calcification of heart, blood vessels, and lungs; symptoms reverse after overdosing is discontinued.
Adverse Effects Among Specific Populations
Individuals with sarcoidosis, other granulomatous diseases, and certain types of lymphoma may quickly develop elevated levels of 1,25(OH)
Pregnancy and Nursing
Vitamin D enters breast milk and is considered compatible at usual dosage levels.
Infants and Children
Vitamin D intakes of 50 to 75 µg (2000-3000 IU) per day may cause toxicity symptoms in some children. Also, some hypersensitive infants have developed toxicity symptoms at 1000 IU/day.
Most cases of toxicity involve the intake of 625 to 1500 µg (25,000-60,000 IU) per day for 1 to 4 months.
Children taking 250 µg (10,000 IU) per day for 4 months can develop the following toxicity symptoms, related to hypercalcemia: headaches, weakness, nausea and vomiting, constipation, polyuria, polydipsia, diarrhea, and calcification of soft tissues, such as kidneys, lungs, tympanic membrane, or ears.
Contraindications
Hypercalcemia, hyperparathyroidism (primary), hypersensitivity to cholecalciferol or any component of the formulation, malabsorption syndrome, sarcoidosis, granulomatous disease, lymphoma; evidence of vitamin D toxicity. If vitamin D insufficiency or deficiency is documented in a patient with lymphoma, cautious supplementation of vitamin D
Precautions and Warnings
- Administer with extreme caution in patients with impaired renal function, heart disease, renal stones, or arteriosclerosis.
- Administer concomitant calcium supplementation.
- Maintain adequate fluid intake.
- Avoid hypercalcemia, although not likely in absence of 1,25(OH)
2 -vitamin D3 excess.
Caution may be appropriate with renal function impairment with secondary hyperparathyroidism. However, impaired renal function is often associated with a need to administer prescription vitamin D as well as D
Strategic Considerations
Several classes of common pharmacological agents interact with vitamin D and its metabolic processes. These interactions take on greater significance in light of the elevated probability of vitamin D deficiency in many of the patient populations likely to be prescribed the medications under consideration. More broadly, the occurrence of vitamin D deficiency has been recognized as being more widespread than previously believed, and in turn the implications of vitamin D insufficiency for health maintenance and disease prevention have become better understood. Thus, although conventional medical practice and governmental nutritional policies have focused on prevention of short-latency deficiency diseases, vitamin D represents a prime example of the growing awareness of the central role of nutritional factors in health maintenance and prevention of long-latency deficiency diseases. Factors such as lack of time outdoors with significant sunlight exposure, air pollution, cultural practices, and geographic population distribution all add to the subtle but profound significance of seasonal decrease in sunlight availability, even in areas generally considered as “sunny.” 7,9,11,36,37The combined effect of these many factors contributes to what some experts have described as an “epidemic” of vitamin D deficiency, affecting 20% to 60% of the population.
The issues of pervasive vitamin D deficiency status and underutilization of laboratory assessment for 25-hydroxyvitamin D levels influence and limit research design, interpretation, and clinical practice within conventional medicine. For example, in 2005, two randomized controlled trials of calcium carbonate and cholecalciferol (vitamin D
In the study in which 1% of the subjects had their vitamin D levels actually measured, there was only a marginal increase after 1 year of supplementation with 800 IU of vitamin D per day (although some supplements, when analyzed, contained as little as 372 IU, mean value, per tablet). Average 25-OHD levels at beginning of the study (15 ng/mL) were in the range of severe deficiency and after 1 year improved only to 24 ng/mL, still well below what many vitamin D researchers consider to be adequate levels (30-40 ng/mL). 40
Subsequently, in a trial involving 944 healthy Icelandic adults, Steingrimsdottir et al. 41 found that with 25-OHD levels below 10 ng/mL, maintaining calcium intake above 800 mg/day appeared to normalize calcium metabolism, as determined by the PTH level, but in individuals with higher 25-OHD levels, no benefit was observed from calcium intake above 800 mg/day. Likewise, Jackson et al. 42 found that the combination of 1000 mg elemental calcium (as calcium carbonate) and 400 IU vitamin D daily did not appreciably reduce risk of hip fracture over 7 years, except in those who took their nutrients regularly. Thus, among adherent women (i.e., those who followed the treatment protocol 80% of the time), the supplements reduced hip fractures by 29%. Nevertheless, the relatively low dose of vitamin D, the use of calcium carbonate (a less-than-optimal form in the opinion of many and one associated with reduced compliance), and the late start and relatively limited duration of supplementation suggest that the treatment protocol was less than adequate (unless consistently adhered to) and thus render these findings less than conclusive. Such studies also indicate the importance of nutrient support throughout adulthood, as opposed to beginning it past midlife. Clearly, further research on calcium and other minerals involved in bone metabolism needs to take into account, and preferably optimize, vitamin D status.
Notably, the main conventional pharmacological intervention against osteoporosis is antiresorptive drugs, such as bisphosphonates, for which almost every clinical trial has included coadministration of calcium or vitamin D. Moreover, the decontextualization and narrow focus of these studies highlight the shortcomings of standard research methodology and clinical practice to account for the broad factors of aging, lifestyle, activity level, drug depletions, and poor nutritional status characteristic of the populations in question, as well as the complex nature of bone health and its reliance on interdependencies of multiple nutrients and tissues, rather than such a narrow focus on supplemental calcium and vitamin D. As public and practitioner attention on vitamin D grows, it may prove a pivotal issue in expanding perceptions and awareness, analysis, and intervention through a broad integrative model more accurately reflecting patient needs and scientifically comprehending the breadth and complexity of the processes involved. 14,24,28,37
The well-known interactions between vitamin D and pharmaceutical medications cluster into several main groups. The use of calcium and vitamin D appears to enhance the bone-maintaining effectiveness of hormone replacement therapy (HRT) and bisphosphonates, especially for women who already have osteoporosis; this benefit appears greater for women supplementing with calcium citrate than for those using calcium carbonate. Anticonvulsants, particularly phenobarbital and phenytoin, may reduce serum levels of calcidiol (25-hydroxycholecalciferol, calcifediol) by altering hepatic metabolism of vitamin D. Notably, physicians prescribing agents that impair vitamin D function for extended periods (e.g., anticonvulsants, opioids, oral cortiocosteroids) usually do not advise or prescribe adequate countermeasures, whether vitamin D and calcium, bisphosphonates, or the combination, to effectively address the common occurrence of drug-induced decreases in bone mineral density and increased risk of fracture. 43,44Numerous medications that alter fat absorption, such as cholestyramine, colestipol, mineral oil, orlistat, and olestra, can interfere with intestinal absorption of vitamin D. Ketoconazole can reduce serum levels of calcitriol. Conversely, excessive vitamin D intake may, in rare cases, induce hypercalcemia and could theoretically precipitate cardiac arrhythmia in patients receiving cardiovascular medications such as verapamil or digoxin. Moreover, cardiac glycosides could potentially increase toxicity. Thiazide diuretics may increase vitamin D effects. Finally, it is now recognized that cholecalciferol inhibits CYP2C8/9, 2C19, and 2D6, although the full implications of such activity and the potential effects on pharmaceuticals metabolized by these enzymes have yet to be fully investigated and documented.
Because vitamin D toxicity from supplemental sources is a real (though improbable) possibility, health care providers are reminded to counsel their patients to avoid taking more than the recommended amount of vitamin D, and to take it in conjunction with a calcium supplement and possibly a special diet. The encouragement of greater exposure to sunlight (outdoors) cannot be overemphasized. Although contrary to prevailing dogma of the past decade and as yet poorly studied, it is becoming increasingly evident that use of high-potency sunscreens that block UVB may significantly contribute to vitamin D deficit. Oral supplementation can be used to compensate for lack of adequate UV exposure from sunlight. However, significantly higher amounts of supplementation may be necessary than previously believed and currently available in most vitamin preparations. Titrating intake to blood level of 25-OHD is the most reliable way to ensure adequate intake.
Although some innovative therapeutic strategies are emerging using vitamin D analogs, most examples of such approaches are considered separately in a brief review later.
Prevention and Reduction of Drug Adverse Effect | Beneficial or Supportive Interaction, with Professional Management |
Probability: 2. Probable
Evidence Base: Consensus
Effect and Mechanism of Action
Decreased levels of sex hormones are generally associated with increased risk of diminished bone mineral density (BMD) and osteoporosis. Supplementation of vitamin D can optimize and preserve bone mass, which tends to be adversely affected by androgen-deprivation therapy (ADT) and is associated with increased risk of osteoporosis and fractures.
Research
Research directly investigating prevention and treatment of osteoporosis caused by ADT is limited. Normally, the incidence of osteoporotic fractures usually increases a decade later in men than in women. Osteoporosis in men with gonadal steroid deficiency can derive from a variety of causes. Gonadotropin-releasing hormone agonists (which, after causing an initial surge in testosterone, result in castrate levels that are maintained as long as the drug is administered) hasten this process and increase bone loss, increasing the risk of osteoporosis and fractures, which have been widely documented in men prescribed ADT for the treatment of prostate carcinoma. 46-53 Four retrospective studies have shown a significant association between ADT and elevated fracture risk in men with prostate cancer. 48,54-56 In particular, with GnRH agonists, men with fractures had lower BMD and higher biochemical markers of bone resorption than men without fractures. 55 Collectively, the available studies indicate that the first year of ADT results in a 5% to 10% decrease in BMD in men with prostate cancer, an effect greater than that associated with menopause. 57 Furthermore, in a cross-sectional study of hormone-naive men with prostate cancer, Smith et al. 58 observed vitamin D deficiency and inadequate dietary intake of calcium in 17% and 59%, respectively.
Smith et al. 59 also found that concurrent treatment with calcium, vitamin D, and pamidronate (a bisphosphonate drug) during ADT increases serum concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. Bisphosphonates have come to play an important role in supporting bone mass. 59-62 Coadministration of vitamin D (and calcium), particularly with bisphosphonates, is generally accepted. 51 The rationale and supporting research are further discussed in the Bisphosphonates section.
Nutritional Therapeutics, Clinical Concerns, and Adaptations
As with postmenopausal women and HRT, concomitant calcium and vitamin D enable and enhance the fundamental preventive support provided by diet and regular weight-bearing exercise in maintaining (or restoring) bone health, particularly bone mass and BMD. Smoking cessation, moderate alcohol consumption, and other supportive lifestyle modification should be also encouraged. The administration of bisphosphonates constitutes a further intervention as part of conventional care. Clinical management should evolve in response to the results of urinary assessment of bone breakdown (e.g., deoxypyridinium metabolites) and radiographic, DXA (dual-energy x-ray absorptiometry), ultrasound, or other techniques for BMD assessment. Oral intake of the bisphosphonate and calcium should be separated by at least 2 hours.
- 1.Tsuritani I, Brooke-Wavell KS, Mastana SS et al. Does vitamin D receptor polymorphism influence the response of bone to brisk walking in postmenopausal women? Horm Res 1998;50:315-319.
- 2.Blanchet C, Giguere Y, Prud’homme D et al. Association of physical activity and bone: influence of vitamin D receptor genotype. Med Sci Sports Exerc 2002;34:24-31.
- 3.Slatter ML, Yakumo K, Hoffman M, Neuhausen S. Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control 2001;12:359-364.View Abstract
- 4.Motohashi Y, Yamada S, Yanagawa T et al. Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. J Clin Endocrinol Metab 2003;88:3137-3140.View Abstract
- 5.Marc J, Prezelj J, Komel R, Kocijancic A. Association of vitamin D receptor gene polymorphism with bone mineral density in Slovenian postmenopausal women. Gynecol Endocrinol 2000;14:60-64.View Abstract
- 6.Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003;78:912-919.View Abstract
- 7.Plotnikoff GA. Vitamin D: the steroid hormone prescription for every patient. Minn Med 2003;86:43-45.View Abstract
- 8.Chapuy MC, Preziosi P, Maamer M et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997;7:439-443.View Abstract
- 9.Thomas MK, Lloyd-Jones DM, Thadhani RI et al. Hypovitaminosis D in medical inpatients. N Engl J Med 1998;338:777-783.View Abstract
- 10.Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-373.View Abstract
- 11.Mezquita-Raya P, Munoz-Torres M, Luna JD et al. Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res 2001;16:1408-1415.
- 12.Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002;112:659-662.
- 13.Tuohimaa P, Lyakhovich A, Aksenov N et al. Vitamin D and prostate cancer. J Steroid Biochem Mol Biol 2001;76:125-134.View Abstract
- 14.Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-856.View Abstract
- 15.Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 2001;73:288-294.View Abstract
- 16.Hewison M, O’Riordan JL. Hormone-nuclear receptor interactions in health and disease: vitamin D resistance. Baillieres Clin Endocrinol Metab 1994;8:305-315.
- 17.Binkley N. Assay variation confounds hypovitaminosis D diagnosis: a call for standardization. Abstract F482. 25th Annual Meeting of the American Society for Bone and Mineral Research. Minneapolis; 2003.
- 18.Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998;351:805-806.View Abstract
- 19.Heaney RP, Davies KM, Chen TC et al. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77:204-210.View Abstract
- 20.Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22:142-146.
- 21.Food and Nutrition Board, Institute of Medicine. Vitamin D. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
- 22.Vieth R, Kimball S, Hu A, Walfish PG. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J 2004;3:8.View Abstract
- 23.Dawson-Hughes B, Heaney RP, Holick MF et al. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713-716.View Abstract
- 24.Holick MF. The vitamin D epidemic and its health consequences. J Nutr 2005;135:2739S-2748S.View Abstract
- 25.Raloff J. Bread and chocolate, no longer D-Minimus. Science News Online 2005;167.
- 26.Mocanu V, Stitt PA, Costan AR et al. Long-term efficacy and safety of high vitamin D intakes as fortified bread. FASEB J 2005;19:A59.
- 27.Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317-322.View Abstract
- 28.Holick MF. High prevalence and clinical implications of vitamin D inadequacy. Mayo Clin Proc 2006;81:353-373.
- 29.Holick MF. The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep 2006;4:96-102.View Abstract
- 30.Vieth R. Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. J Nutr 2006;136:1117-1122.View Abstract
- 31.Whiting SJ, Calvo MS. Overview. Proceedings from Experimental Biology 2005 Symposium. Optimizing Vitamin D Intake for Populations with Special Needs: Barriers to Effective Food Fortification and Supplementation. J Nutr 2006;136:1114-1116.View Abstract
- 32.Lappe JM, Davies KM, Travers-Gustafson D, Heaney RP. Vitamin D status in a rural postmenopausal female population. J Am Coll Nutr 2006;25:395-402.View Abstract
- 33.Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr 2007;85:6-18.View Abstract
- 34.Heaney RP. Barriers to optimizing vitamin D3 intake for the elderly. J Nutr 2006;136:1123-1125.View Abstract
- 35.Tuohimaa P, Tenkanen L, Ahonen M et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer 2004;108:104-108.View Abstract
- 36.Semba RD, Garrett E, Johnson BA et al. Vitamin D deficiency among older women with and without disability. Am J Clin Nutr 2000;72:1529-1534.
- 37.Heaney RP. Vitamin D, nutritional deficiency, and the medical paradigm. J Clin Endocrinol Metab 2003;88:5107-5108.View Abstract
- 38.Porthouse J, Cockayne S, King C et al. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ2005;330:1003.
- 39.Grant AM, Avenell A, Campbell MK et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium or Vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005;365:1621-1628.View Abstract
- 40.Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004;79:362-371.View Abstract
- 41.Steingrimsdottir L, Gunnarsson O, Indridason OS et al. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005;294:2336-2341.
- 42.Jackson RD, LaCroix AZ, Gass M et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-683.View Abstract
- 43.Kinjo M, Setoguchi S, Schneeweiss S, Solomon DH. Bone mineral density in subjects using central nervous system-active medications. Am J Med 2005;118:1414.View Abstract
- 44.Liu RH, Albrecht J, Werth VP. Cross-sectional study of bisphosphonate use in dermatology patients receiving long-term oral corticosteroid therapy. Arch Dermatol 2006;142:37-41.View Abstract
- 45.Takahashi S, Yamamoto T, Moriwaki Y et al. Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout. Adv Exp Med Biol 1998;431:57-60.View Abstract
- 46.Wei JT, Gross M, Jaffe CA et al. Androgen deprivation therapy for prostate cancer results in significant loss of bone density. Urology 1999;54:607-611.View Abstract
- 47.Kiratli BJ, Srinivas S, Perkash I, Terris MK. Progressive decrease in bone density over 10 years of androgen deprivation therapy in patients with prostate cancer. Urology 2001;57:127-132.View Abstract
- 48.Daniell HW. Osteoporosis due to androgen deprivation therapy in men with prostate cancer. Urology 2001;58:101-107.View Abstract
- 49.Basaria S, Lieb J 2nd, Tang AM et al. Long-term effects of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol (Oxf) 2002;56:779-786.View Abstract
- 50.Chen Z, Maricic M, Nguyen P et al. Low bone density and high percentage of body fat among men who were treated with androgen deprivation therapy for prostate carcinoma. Cancer 2002;95:2136-2144.
- 51.Smith MR. Osteoporosis during androgen deprivation therapy for prostate cancer. Urology 2002;60:79-85; discussion 86.
- 52.Mittan D, Lee S, Miller E et al. Bone loss following hypogonadism in men with prostate cancer treated with GnRH analogs. J Clin Endocrinol Metab 2002;87:3656-3661.View Abstract
- 53.Diamond TH, Higano CS, Smith MR et al. Osteoporosis in men with prostate carcinoma receiving androgen-deprivation therapy: recommendations for diagnosis and therapies. Cancer 2004;100(5):892-899.View Abstract
- 54.Oefelein MG, Ricchuiti V, Conrad W et al. Skeletal fracture associated with androgen suppression induced osteoporosis: the clinical incidence and risk factors for patients with prostate cancer. J Urol 2001;166:1724-1728.View Abstract
- 55.Hatano T, Oishi Y, Furuta A et al. Incidence of bone fracture in patients receiving luteinizing hormone–releasing hormone agonists for prostate cancer. BJU Int 2000;86:449-452.View Abstract
- 56.Townsend MF, Sanders WH, Northway RO, Graham SD Jr. Bone fractures associated with luteinizing hormone–releasing hormone agonists used in the treatment of prostate carcinoma. Cancer 1997;79:545-550.View Abstract
- 57.Eastell R. Treatment of postmenopausal osteoporosis. N Engl J Med 1998;338:736-746.View Abstract
- 58.Smith MR, McGovern FJ, Fallon MA et al. Low bone mineral density in hormone-naive men with prostate carcinoma. Cancer 2001;91:2238-2245.View Abstract
- 59.Smith MR, McGovern FJ, Zietman AL et al. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 2001;345:948-955.
- 60.Smith MR. Bisphosphonates to prevent osteoporosis in men receiving androgen deprivation therapy for prostate cancer. Drugs Aging 2003;20:175-183.View Abstract
- 61.Higano CS. Management of bone loss in men with prostate cancer. J Urol 2003;170:S59-S63; discussion S64.View Abstract
- 62.Smith MR, Eastham J, Gleason DM et al. Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 2003;169:2008-2012.View Abstract
- 63.Winnacker JL, Yeager H, Saunders JA et al. Rickets in children receiving anticonvulsant drugs: biochemical and hormonal markers. Am J Dis Child 1977;131:286-290.View Abstract
- 64.Adachi JD, Ioannidis G. Calcium and vitamin D therapy in corticosteroid-induced bone loss: what is the evidence? Calcif Tissue Int 1999;65:332-336.
- 65.Zerwekh JE, Homan R, Tindall R, Pak CY. Decreased serum 24,25-dihydroxyvitamin D concentration during long-term anticonvulsant therapy in adult epileptics. Ann Neurol 1982;12:184-186.
- 66.Williams C, Netzloff M, Folkerts L et al. Vitamin D metabolism and anticonvulsant therapy: effect of sunshine on incidence of osteomalacia. South Med J 1984;77:834-836, 842.View Abstract
- 67.Riancho JA, del Arco C, Arteaga R et al. Influence of solar irradiation on vitamin D levels in children on anticonvulsant drugs. Acta Neurol Scand 1989;79:296-299.View Abstract
- 68.Hunt PA, Wu-Chen ML, Handal NJ et al. Bone disease induced by anticonvulsant therapy and treatment with calcitriol (1,25-dihydroxyvitamin D3). Am J Dis Child 1986;140:715-718.View Abstract
- 69.Jekovec-Vrhovsek M, Kocijancic A, Prezelj J. Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care. Dev Med Child Neurol 2000;42:403-405.View Abstract
- 70.Telci A, Cakatay U, Kurt BB et al. Changes in bone turnover and deoxypyridinoline levels in epileptic patients. Clin Chem Lab Med 2000;38:47-50.View Abstract
- 71.Farhat G, Yamout B, Mikati MA et al. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology 2002;58:1348-1353.View Abstract
- 72.Jetter GM, Moreno L, Rogers S et al. Changes in vitamin D levels associated with enzyme-inducing AEDs in male epilepsy patients. Abstract B.03. First North American Epilepsy Congress: 60th Annual Meeting of the American Epilepsy Society. San Diego; 2006.
- 73.Valmadrid C, Voorhees C, Litt B, Schneyer CR. Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy. Arch Neurol 2001;58:1369-1374.
- 74.Mikati MA, Dib L, Yamout B et al. Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. Neurology 2006;67:2005-2014.View Abstract
- 75.Duus BR. Fractures caused by epileptic seizures and epileptic osteomalacia. Injury 1986;17:31-33.View Abstract
- 76.Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc 1997;56:915-937.View Abstract
- 77.Heaney RP. Constructive interactions among nutrients and bone-active pharmacologic agents with principal emphasis on calcium, phosphorus, vitamin D and protein. J Am Coll Nutr 2001;20:403S-409S; discussion 417S-420S.
- 78.Heaney RP, Weaver CM. Calcium and vitamin D. Endocrinol Metab Clin North Am 2003;32:181-194, vii-viii.View Abstract
- 79.Greenspan SL, Resnick NM, Parker RA. Combination therapy with hormone replacement and alendronate for prevention of bone loss in elderly women: a randomized controlled trial. JAMA 2003;289:2525-2533.View Abstract
- 80.Heckman GA, Papaioannou A, Sebaldt RJ et al. Effect of vitamin D on bone mineral density of elderly patients with osteoporosis responding poorly to bisphosphonates. BMC Musculoskelet Disord 2002;3:6.View Abstract
- 81.Brazier M, Kamel S, Lorget F et al. Biological effects of supplementation with vitamin D and calcium in postmenopausal women with low bone mass receiving alendronate. Clin Drug Invest 2002;22:849-857.
- 82.Siffledeen JS, Fedorak RN, Siminoski K et al. Randomized trial of etidronate plus calcium and vitamin D for treatment of low bone mineral density in Crohn’s disease. Clin Gastroenterol Hepatol 2005;3:122-132.
- 83.Bernstein CN. Limiting fracture risk in Crohn’s disease: is there anything better than calcium and vitamin D? Clin Gastroenterol Hepatol 2005;3:110-112.
- 84.Nelson JB, Greenspan SL, Resnick NM et al. Once-weekly oral alendronate prevents bone loss in men on androgen deprivation therapy for prostate cancer. Abstract 139. American Society of Clinical Oncology Prostate Cancer Symposium. San Francisco; 2006.
- 85.Flicker L, Mead K, MacInnis RJ et al. Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc 2003;51:1533-1538.View Abstract
- 86.Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr 2002;75:611-615.View Abstract
- 87.West RJ, Lloyd JK. The effect of cholestyramine on intestinal absorption. Gut 1975;16:93-98.View Abstract
- 88.Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44:124-129.View Abstract
- 89.Roe DA. Drug-Induced Nutritional Deficiencies. 2nd ed. Westport, Conn: Avi Publishing; 1985.
- 90.Tonstad S, Sivertsen M, Aksnes L, Ose L. Low dose colestipol in adolescents with familial hypercholesterolaemia. Arch Dis Child 1996;74:157-160.View Abstract
- 91.Watkins DW, Khalafi R, Cassidy MM, Vahouny GV. Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine. Dig Dis Sci 1985;30:477-482.View Abstract
- 92.Anonymous. Cimetidine inhibits the hepatic hydroxylation of vitamin D. Nutr Rev 1985;43:184-185.
- 93.Odes HS, Fraser GM, Krugliak P et al. Effect of cimetidine on hepatic vitamin D metabolism in humans. Digestion 1990;46:61-64.View Abstract
- 94.Hahn TJ, Halstead LR, Baran DT. Effects off short-term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 1981;52:111-115.View Abstract
- 95.Hahn TJ, Hendin BA, Scharp CR, Haddad JG Jr. Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. N Engl J Med 1972;287:900-904.View Abstract
- 96.Hodges R. Drug-nutrient interaction. Nutrition in Medical Practice. Philadelphia: Saunders; 1980:323-331.
- 97.Avioli LV. Effects of chronic corticosteroid therapy on mineral metabolism and calcium absorption. Adv Exp Med Biol 1984;171:81-89.View Abstract
- 98.Chesney RW, Mazess RB, Hamstra AJ et al. Reduction of serum 1,25-dihydroxyvitamin D3 in children receiving glucocorticoids. Lancet 1978;2:1123-1125.View Abstract
- 99.Nielsen HK, Eriksen EF, Storm T, Mosekilde L. The effects of short-term, high-dose treatment with prednisone on the nuclear uptake of 1,25-dihydroxyvitamin D3 in monocytes from normal human subjects. Metabolism 1988;37:109-114.View Abstract
- 100.Yeh JK, Aloia JF, Semla HM. Interrelation of cortisone and 1,25-dihydroxycholecalciferol on intestinal calcium and phosphate absorption. Calcif Tissue Int 1984;36:608-614.View Abstract
- 101.Hahn TJ, Halstead LR, Haddad JG Jr. Serum 25-hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy. J Lab Clin Med 1977;90:399-404.View Abstract
- 102.Buckley LM, Leib ES, Cartularo KS et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1996;125:961-968.View Abstract
- 103.Lems WF, Van Veen GJ, Gerrits MI et al. Effect of low-dose prednisone (with calcium and calcitriol supplementation) on calcium and bone metabolism in healthy volunteers. Br J Rheumatol 1998;37:27-33.View Abstract
- 104.Wissing KM, Broeders N, Moreno-Reyes R et al. A controlled study of vitamin D3 to prevent bone loss in renal-transplant patients receiving low doses of steroids. Transplantation 2005;79:108-115.View Abstract
- 105.Amin S, LaValley MP, Simms RW, Felson DT. The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach. Arthritis Rheum 1999;42:1740-1751.View Abstract
- 106.Leone FT, Fish JE, Szefler SJ, West SL. Systematic review of the evidence regarding potential complications of inhaled corticosteroid use in asthma: collaboration of American College of Chest Physicians, American Academy of Allergy, Asthma, and Immunology, and American College of Allergy, Asthma, and Immunology. Chest 2003;124:2329-2340.
- 107.Elmstahl S, Ekstrom H, Galvard H et al. Is there an association between inhaled corticosteroids and bone density in postmenopausal women? J Allergy Clin Immunol 2003;111:91-96.
- 108.Suissa S, Baltzan M, Kremer R, Ernst P. Inhaled and nasal corticosteroid use and the risk of fracture. Am J Respir Crit Care Med 2004;169:83-88.View Abstract
- 109.Lems WF, Jacobs JW, Netelenbos JC et al. [Pharmacological prevention of osteoporosis in patients on corticosteroid medication]. Ned Tijdschr Geneeskd 1998;142:1904-1908.View Abstract
- 110.Lobo RA, Roy S, Shoupe D et al. Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically-induced postmenopausal women. Horm Metab Res 1985;17:370-373.View Abstract
- 111.Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab 1992;75:519-523.View Abstract
- 112.Komulainen M, Tuppurainen MT, Kroger H et al. Vitamin D and HRT: no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women: a 2.5-year randomized placebo-controlled study. Osteoporos Int 1997;7:126-132.View Abstract
- 113.Komulainen MH, Kroger H, Tuppurainen MT et al. HRT and vit D in prevention of non-vertebral fractures in postmenopausal women: a 5 year randomized trial. Maturitas 1998;31:45-54.View Abstract
- 114.Komulainen M, Kroger H, Tuppurainen MT et al. Prevention of femoral and lumbar bone loss with hormone replacement therapy and vitamin D3 in early postmenopausal women: a population-based 5-year randomized trial. J Clin Endocrinol Metab 1999;84:546-552.View Abstract
- 115.Tuppurainen MT, Komulainen M, Kroger H et al. Does vitamin D strengthen the increase in femoral neck BMD in osteoporotic women treated with estrogen? Osteoporos Int 1998;8:32-38.
- 116.Recker RR, Davies KM, Dowd RM, Heaney RP. The effect of low-dose continuous estrogen and progesterone therapy with calcium and vitamin D on bone in elderly women: a randomized, controlled trial. Ann Intern Med 1999;130:897-904.View Abstract
- 117.Gallagher JC, Riggs BL, DeLuca HF. Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 1980;51:1359-1364.View Abstract
- 118.Gallagher JC, Fowler SE, Detter JR, Sherman SS. Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrinol Metab 2001;86:3618-3628.View Abstract
- 119.Heller HJ, Poindexter JR, Adams-Huet B. Effect of estrogen treatment and vitamin D status on differing bioavailabilities of calcium carbonate and calcium citrate. J Clin Pharmacol 2002;42:1251-1256.View Abstract
- 120.Willing M, Sowers M, Aron D et al. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res 1998;13:695-705.View Abstract
- 121.Deng HW, Li J, Li JL et al. Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int 1999;9:499-507.View Abstract
- 122.Myrup B, Jensen GF, McNair P. Cardiovascular risk factors during estrogen-norethindrone and cholecalciferol treatment. Arch Intern Med 1992;152:2265-2268.
- 123.Heikkinen AM, Tuppurainen MT, Niskanen L et al. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol 1997;137:495-502.
- 124.Going S, Lohman T, Houtkooper L et al. Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporos Int 2003;14:637-643.
- 125.Milliken LA, Going SB, Houtkooper LB et al. Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. Calcif Tissue Int 2003;72:478-484.
- 126.Aarskog D, Aksnes L, Markestad T et al. Heparin-induced inhibition of 1,25-dihydroxyvitamin D formation. Am J Obstet Gynecol 1984;148:1141-1142.View Abstract
- 127.Majerus PW, Broze GJ Jr, Miletich JP, Tollefsen DM. Anticoagulant, thrombolytic, and antiplatelet drugs. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; 1996:1346.
- 128.Wise PH, Hall AJ. Heparin-induced osteopenia in pregnancy. BMJ 1980;281:110-111.View Abstract
- 129.Haram K, Hervig T, Thordarson H, Aksnes L. Osteopenia caused by heparin treatment in pregnancy. Acta Obstet Gynecol Scand 1993;72:674-675.View Abstract
- 130.Ringe JD, Keller A. [Risk of osteoporosis in long-term heparin therapy of thromboembolic diseases in pregnancy: attempted prevention with ossein-hydroxyapatite]. Geburtshilfe Frauenheilkd 1992;52:426-429.View Abstract
- 131.Brodie MJ, Boobis AR, Hillyard CJ et al. Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity. Clin Pharmacol Ther 1981;30:363-367.View Abstract
- 132.Bengoa JM, Bolt MJ, Rosenberg IH. Hepatic vitamin D 25-hydroxylase inhibition by cimetidine and isoniazid. J Lab Clin Med 1984;104:546-552.View Abstract
- 133.Toppet M, Vainsel M, Vertongen F et al. [Sequential development of vitamin D metabolites under isoniazid and rifampicin therapy]. Arch Fr Pediatr 1988;45:145-148.View Abstract
- 134.Morcos MM, Gabr AA, Samuel S et al. Vitamin D administration to tuberculous children and its value. Boll Chim Farm 1998;137:157-164.View Abstract
- 135.Loose DS, Kan PB, Hirst MA et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450–dependent enzymes. J Clin Invest 1983;71:1495-1499.View Abstract
- 136.Borgers M, Van den Bossche H, De Brabander M. The mechanism of action of the new antimycotic ketoconazole. Am J Med 1983;74:2-8.View Abstract
- 137.Peehl DM, Seto E, Feldman D. Rationale for combination ketoconazole/vitamin D treatment of prostate cancer. Urology 2001;58:123-126.View Abstract
- 138.Adams JS, Sharma OP, Diz MM, Endres DB. Ketoconazole decreases the serum 1,25-dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia. J Clin Endocrinol Metab 1990;70:1090-1095.View Abstract
- 139.Glass AR, Eil C. Ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab 1986;63:766-769.View Abstract
- 140.Glass AR, Eil C. Ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin D and total serum calcium in hypercalcemic patients. J Clin Endocrinol Metab 1988;66:934-938.View Abstract
- 141.Glass AR, Cerletty JM, Elliott W et al. Ketoconazole reduces elevated serum levels of 1,25-dihydroxyvitamin D in hypercalcemic sarcoidosis. J Endocrinol Invest 1990;13:407-413.View Abstract
- 142.Breslau NA, Preminger GM, Adams BV et al. Use of ketoconazole to probe the pathogenetic importance of 1,25-dihydroxyvitamin D in absorptive hypercalciuria. J Clin Endocrinol Metab 1992;75:1446-1452.View Abstract
- 143.James WP, Avenell A, Broom J, Whitehead J. A one-year trial to assess the value of orlistat in the management of obesity. Int J Obes Relat Metab Disord 1997;21 Suppl 3:S24-S30.View Abstract
- 144.Van Gaal LF, Broom JI, Enzi G, Toplak H. Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study. Orlistat Dose-Ranging Study Group. Eur J Clin Pharmacol 1998;54:125-132.View Abstract
- 145.McDuffie JR, Calis KA, Booth SL et al. Effects of orlistat on fat-soluble vitamins in obese adolescents. Pharmacotherapy 2002;22:814-822.View Abstract
- 146.Boivin G, Lips P, Ott SM et al. Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 2003;88:4199-4205.View Abstract
- 147.Brodie MJ, Boobis AR, Dollery CT et al. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther 1980;27:810-814.View Abstract
- 148.Riis B, Christiansen C. Actions of thiazide on vitamin D metabolism: a controlled therapeutic trial in normal women early in the postmenopause. Metabolism 1985;34:421-424.View Abstract
- 149.Hartigan-Go K, Bateman DN, Nyberg G et al. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Clin Pharmacol Ther 1996;60:543-553.View Abstract
- 150.Novartis. Mellaril [package insert]. East Hanover, NJ: Novartis Pharmaceuticals; 2000.
- 151.Lerner U, Gustafson GT. Inhibition of 1 alpha-hydroxy-vitamin D3 stimulated bone resorption in tissue culture by the calcium antagonist verapamil. Eur J Clin Invest 1982;12:185-190.View Abstract
- 152.Fox J, Della-Santina CP. Oral verapamil and calcium and vitamin D metabolism in rats: effect of dietary calcium. Am J Physiol 1989;257:E632-E638.View Abstract
- 153.Bar-Or D, Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. Br Med J Clin Res Ed 1981;282:1585-1586.View Abstract
- 154.Holick MF. Personal communication with MB Stargrove; Dec 8, 2004.
- 155.Stio M, Treves C, Celli A et al. Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis. Am J Gastroenterol 2002;97:679-689.View Abstract
- 156.Sundaram S, Sea A, Feldman S et al. The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. Clin Cancer Res 2003;9:2350-2356.View Abstract
- 157.Dunlap N, Schwartz GG, Eads D et al. 1α,25-Dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1α,25(OH)(2)D(2), potentiate the effects of ionising radiation on human prostate cancer cells. Br J Cancer 2003;89:746-753.
- 158.Beer TM, Eilers KM, Garzotto M et al. Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. J Clin Oncol 2003;21:123-128.View Abstract
- 159.Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-556.View Abstract
- 160.Ravid A, Rocker D, Machlenkin A et al. 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. Cancer Res 1999;59:862-867.View Abstract
- 161.Buck AC, Brown RC, Davies CJ et al. The influence of flurbiprofen on calcium excretion and vitamin D3 in recurrent calcium lithiasis: a double blind study. Proceedings of the 5th International Symposium on Urolithiasis and Related Clinical Research. Garmisch; 1984.
- 162.Brown RC, Heyburn PJ, Littlewood TJ, Beck P. Prostaglandin synthetase inhibition in hypercalcaemia with sarcoidosis. Lancet 1984;2:37.View Abstract
- 163.Barré PE, Gascon-Barré M, Meakins JL, Goltzman D. Hydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysis. Am J Med 1987;82:1259-1262.
- 164.Diarrhea and constipation. In: Berkow R, Fletcher AJ, Beers MH et al, eds. The Merck Manual of Diagnosis and Therapy. 16th ed. Rahway, NJ: Merck Research Laboratories; 1992.
- 165.Kassem M, Mosekilde L, Eriksen EF. 1,25-Dihydroxyvitamin D3 potentiates fluoride-stimulated collagen type I production in cultures of human bone marrow stromal osteoblast-like cells. J Bone Miner Res 1993;8:1453-1458.View Abstract
- 166.Patty I, Tarnok F, Simon L et al. A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). Acta Physiol Hung 1984;64:379-384.View Abstract
- 167.Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93-96.View Abstract
- 168.Schrogie JJ. Coagulopathy and fat-soluble vitamins [letter]. JAMA 1975;232:19.View Abstract
- 169.Hunt CD. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect 1994;102 Suppl 7:35-43.View Abstract
- 170.Hunt CD, Herbel JL, Idso JP. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res 1994;9:171-182.View Abstract
- 171.Hunt CD. Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biol Trace Elem Res 1989;22:201-220.View Abstract
- 172.Dupre JN, Keenan MJ, Hegsted M, Brudevold AM. Effects of dietary boron in rats fed a vitamin D–deficient diet. Environ Health Perspect 1994;102 Suppl 7:55-58.View Abstract
- 173.Nielsen FH, Shuler TR, Gallagher SK. Effects of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet. J Trace Elem Exp Med 1990;3:45-54.
- 174.Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700.View Abstract
- 175.Dawson-Hughes B, Dallal GE, Krall EA et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991;115:505-512.
- 176.Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-676.View Abstract
- 177.Baeksgaard L, Andersen KP, Hyldstrup L. Calcium and vitamin D supplementation increases spinal BMD in healthy, postmenopausal women. Osteoporos Int 1998;8:255-260.View Abstract
- 178.Avenell A, Handoll HHG. Nutritional supplementation for hip fracture aftercare in older people. Cochrane Database Syst Rev 2005:CD001880.
- 179.Boonen S, Haentjens P, Vanderschueren D, Lips P. Fracture risk reduction with vitamin D supplementation requires additional calcium: evidence from a comparative meta-analysis. Osteoporos Int 2006;17:13.
- 180.Breslau NA, McGuire JL, Zerwekh JE, Pak CY. The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism. J Clin Endocrinol Metab 1982;55:369-373.View Abstract
- 181.Kummerow FA, Cho BH, Huang WY et al. Additive risk factors in atherosclerosis. Am J Clin Nutr 1976;29:579-584.View Abstract
- 182.Kamio A, Kummerow FA, Imai H. Degeneration of aortic smooth muscle cells in swine fed excess vitamin D3. Arch Pathol Lab Med 1977;101:378-381.View Abstract
- .[No authors listed.] Nutrients and nutritional agents. In: Kastrup EK, Hines Burnham T, Short RM, et al, eds. Drug facts and comparisons. St Louis: Facts and Comparisons; 2000. (Review)
- .[No authors listed.] Vitamins. In: Kastrup EK, Hines Burnham T, Short RM, et al, eds. Drug facts and comparisons. St Louis: Facts and Comparisons; 2000:6-33. (Review)
- .Aaron JE, Gallagher JC, Anderson J, et al. Frequency of osteomalacia and osteoporosis in fractures of the proximal femur. Lancet 1974;1(7851):229-233.
- .Aarskog D, Aksnes L, Lehmann V. Low 1,25-dihydroxyvitamin D in heparin-induced osteopenia. Lancet 1980;2(8195 Pt 1):650-651. (Letter)
- .Adachi R, Shulman AI, Yamamoto K, et al. Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Mol Endocrinol 2004;18(1):43-52.
- .Adler RA, Funkhouser HL, Petkov VI, et al. Glucocorticoid-induced osteoporosis in patients with sarcoidosis. Am J Med Sci 2003;325(1):1-6.
- .Agarwal KS, Mughal MZ, Upadhyay P, et al. The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child 2002;87(2):111-113.
- .Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine 2003;28(2):177-179.
- .Albertazzi P, Steel SA, Purdie DW, et al. Hyperparathyroidism in elderly osteopenic women. Maturitas 2002;43(4):245-249.
- .Aloia JF, Talwar SA, Pollack S, et al. A randomized controlled trial of vitamin D3 supplementation in African American women. Arch Intern Med 2005;165:1618-1623.
- .American Academy of Sciences. Dietary reference intakes: calcium phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997.
- .Amin S, Zhang Y, Felson DT, et al. Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 2006;119(5):426-433.
- .Andreassen H, Rix M, Brot C, et al. Regulators of calcium homeostasis and bone mineral density in patients with Crohn’s disease. Scand J Gastroenterol 1998;33(10):1087-1093.
- .Bao BY, Yao J, Lee YF. 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis 2006;27(9):1883-1893.
- .Bao BY, Yeh SD, Lee YF. 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 2006;27(1):32-42.
- .Barber K, Purnell-O’Neal M. The politics of vitamin D: questioning universal supplementation. Mothering Magazine 2003:117.
- .Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab 2002;87(11):4952-4956.
- .Barnes MS, Robson PJ, Bonham MP, et al. Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults. Eur J Clin Nutr 2006;60:727-733.
- .Barrueto F, Wang-Flores HH, Howland MA, et al. Acute vitamin D intoxication in a child. Pediatrics 2005;116:453-456.
- .Basha B, Rao S, Han ZH, et al. Osteomalacia due to vitamin D depletion: neglected consequence of intestinal malabsorption. Am J Med 2000;108:296-300.
- .Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Saf 1998;19(5):355-371. (Review)
- .Bengoa JM, Bolt MJ, Rosenberg IH. Hepatic vitamin D 25-hydroxylase inhibition by cimetidine and isoniazid. J Lab Clin Med 1984;104(4):546-552.
- .Bertone-Johnson ER, Hankinson SE, Bendich A, et al. Calcium and vitamin D intake and risk of incident premenstrual syndrome. Arch Intern Med 2005;165(11):1246-1252.
- .Binkley N, et al. Assay variation confounds hypovitaminosis D diagnosis: a call for standardization. Abstract F482. 25th Annual Meeting of the American Society for Bone and Mineral Research. Minneapolis, Sep 2003.
- .Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18(2):343-351.
- .Bischoff-Ferrari HA, Conzelmann M, Dick W, et al. [Effect of vitamin D on muscle strength and relevance in regard to osteoporosis prevention.] Z Rheumatol 2003;62(6):518-521. [German]
- .Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004;291:1999-2006.
- .Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 2004;80(3):752-758.
- .Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006;84(1):18-28. (Review)
- .Bischoff-Ferrari HA, Zhang Y, Kiel DP, et al. Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis Rheum 2005;53(6):821-826.
- .Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 2006;166:424-430.
- .Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey. Chest 2005;128:3792-3798.
- .Blanchet C, Giguere Y, Prud’homme D, et al. Association of physical activity and bone: influence of vitamin D receptor genotype. Med Sci Sports Exerc 2002;34(1):24-31.
- .Blank RD, Bockman RS. A review of clinical trials of therapies for osteoporosis using fracture as an end point. J Clin Densitom 1999;2(4):435-452.
- .Blutt SE, Weigel NL. Vitamin D and prostate cancer. Proc Soc Exp Biol Med 1999;221(2):89-98.
- .Bonjour J-P, Carrie AL, Ferrari S, et al. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. J Clin Invest 1997;99:1287-1294.
- .Boonen S, Bischoff-Ferrari HA, Cooper C, et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int 2006;78(5):257-270. (Review)
- .Boonen S, Haentjens P, Vanderschueren D, et al. Fracture risk reduction with vitamin D supplementation requires additional calcium: evidence from a comparative meta-analysis. Osteoporos Int 2006;17(Suppl 2):13. (Meta-analysis)
- .Boonen S, Vanderschueren D, Haentjens P, et al. Calcium and vitamin D in the prevention and treatment of osteoporosis: a clinical update. J Intern Med 2006;259(6):539-552. (Review)
- .Borissova AM, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003;57(4):258-261.
- .Bostick RM, Potter JD, Sellers TA, et al. Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women: the Iowa Women’s Health Study. Am J Epidemiol 1993;137(12):1302-1317.
- .Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149(2):151-161.
- .Boucher BJ. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’? Br J Nutr 1998;79:315-327.
- .Braun J, Sieper J. [Glucocorticoid-induced osteoporosis.] Orthopade 2001;30(7):444-450. [German]
- .Brawley OW, Parnes H. Prostate cancer prevention trials in the USA. Eur J Cancer 2000;36(10):1312-1315.
- .Brazier M, Kamel S, Maamer M, et al. The markers of bone remodeling in the elderly subject: effects of vitamin D insufficiency and its correction. J Bone Miner Res 1995;10:1753-1761.
- .Brenner RV, Shabahang M, Schumaker LM, et al. The antiproliferation effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Lett 1995;92:77-82.
- .Bretherton-Watt D, Given-Wilson R, Mansi JL, et al. Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer 2001;85(2):171-175.
- .Brodie MJ, Boobis AR, Hillyard CJ, et al. Effect of rifampicin and isoniazid on vitamin D metabolism. Clin Pharmacol Ther 1982;32(4):525-530.
- .Brody T. Nutritional biochemistry. 2nd ed. San Diego: Academic Press; 1999.
- .Brookes GB. Vitamin D deficiency and deafness: 1984 update. Am J Otol 1985;6(1):102-107.
- .Brot C, Vestergaard P, Kolthoff N, et al. Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr 2001;86(Suppl 1):S97-103.
- .Brown RC, Heyburn PJ, Littlewood TJ, et al. Prostaglandin synthetase inhibition in hypercalcaemia with sarcoidosis. Lancet 1984;2:37. (Letter)
- .Brown SA, Ontjes DA, Lester GE, et al. Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. Osteoporos Int 2003;14(5):442-449.
- .Brown SJ. The role of vitamin D in multiple sclerosis. Ann Pharmacother 2006;40(6):1158-1161. (Review)
- .Buist N. Vitamin D deficiency in Oregon: nutritional rickets resurgent. Doernbecher J 2000;6(2):13-17.
- .Buist RA. Drug-nutrient interactions: an overview. Int Clin Nutr Rev 1984;4(3):114. (Review)
- .Butler LM, Centenera MM, Neufing PJ, et al. Suppression of androgen receptor signaling in prostate cancer cells by an inhibitory receptor variant. Mol Endocrinol 2006;20(5):1009-1024.
- .Caca-Biljanovska NG, Vlckova-Laskoska MT, Dervendi DV, et al. Treatment of generalized morphea with oral 1,25-dihydroxyvitamin D3. Adv Exp Med Biol 1999;455:299-304.
- .Calvo MS. Dietary considerations to prevent loss of bone and renal function. Nutrition 2000;16(7-8):564-566.
- .Calvo MS, Whiting SJ. Public health strategies to overcome barriers to optimal vitamin D status in populations with special needs. J Nutr 2006;136(4):1135-1139.
- .Calvo MS, Whiting SJ, Barton CN. Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr 2004;80:1710S-1716S.
- .Camici M. Dialysis-associated bone disease. JAMA 1986;256(11):1447. (Letter)
- .Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006;134(6):1129-1140.
- .Cantorna MT. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med 2000;223(3):230-233. (Review)
- .Cantorna MT, Zhu Y, Froicu M, et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004;80:1717S-1720S.
- .Cardella CJ, Birkin BL, Rapoport A. Role of dialysis in the treatment of severe hypercalcemia: report of two cases successfully treated with hemodialysis and review of the literature. Clin Nephrol 1979;12(6):285-290.
- .Castells S, Greig F, Fusi MA, et al. Severely deficient binding of 1,25-dihydroxyvitamin D to its receptors in a patient responsive to high doses of this hormone. J Clin Endocrinol Metab 1986;63:252-256.
- .Cetaruk EW, Aaron CK. Hazards of nonprescription medications. Emerg Med Clin North Am 1994;12(2):483-510.
- .Chan JM, Giovannucci E, Andresson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes Control 1998;9(6):559-566.
- .Chapuy MC, Arlot ME, Delmas PD, et al. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994;308(6936):1081-1082.
- .Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-1642.
- .Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002;13(3):257-264.
- .Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis Int 1997;7(5):439-443.
- .Chen TC, Holick MF. Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 2003;14(9):423-430.
- .Chen TC, Holick MF, Lokeshwar BL, et al. Evaluation of vitamin D analogs as therapeutic agents for prostate cancer. Recent Results Cancer Res 2003;164:273-288.
- .Chiu KC, Chu A, Go VLW, et al. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79:820-825.
- .Christiansen C, Rodbro P. [Anticonvulsant-induced osteomalacia: vitamin D metabolism disorders in epileptics on anticonvulsant therapy.] Ugeskr Laeger 1979;141(5):280-284. [Danish]
- .Christiansen C, Rodbro P, Lund M. Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial. Br Med J 1973;4(894):695-701.
- .Chiu KC, Chu A, Go VL, et al. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79(5):820-825.
- .Chung S, Ahn C. Effects of anti-epileptic drug therapy on bone mineral density in ambulatory epileptic children. Brain Dev 1994;16(5):382-385.
- .Clemens TL, Adams JS, Henderson SL, et al. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1982;1(8263):74-76.
- .Collins N, Maher J, Cole M, et al. A prospective study to evaluate the dose of vitamin D required to correct low 25-hydroxyvitamin D levels, calcium, and alkaline phosphatase in patients at risk of developing antiepileptic drug-induced osteomalacia. Q J Med 1991;78(286):113-122.
- .Dahlman T, Lindvall N, Hellgren M. Osteopenia in pregnancy during long-term heparin treatment: a radiological study post partum. Br J Obstet Gynaecol 1990;97(3):221-228.
- .Dawson-Hughes B. Calcium and vitamin D nutritional needs of elderly women. J Nutr 1996;126(4 Suppl):116S-117S.
- .Dawson-Hughes B. Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. Am J Clin Nutr 2004;80:1763S-1766S.
- .Dawson-Hughes B, Dallal GE, Krall EA, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991;115(7):505-512.
- .Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr 1997;65:67-71.
- .Dawson-Hughes B, Harris SS, Krall EA, et al. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr 1995;61(5):1140-1145.
- .Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337(10):670-676.
- .Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women. Am J Clin Nutr 2000;72(3):745-750.
- .Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713-716.
- .Deal CL. Osteoporosis: prevention, diagnosis, and management. Am J Med 1997;102(1A):35S-39S. (Review)
- .DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;80:1689S-1696S.
- .DeLuca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 2001;15(14):2579-2585.
- .DeLuca HF, Zierold C. Mechanisms and functions of vitamin D. Nutr Rev 1998;56(2 Pt 2):S4-10.
- .Deng HW, Li J, Li JL, et al. Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes. Hum Genet 1998;103(5):576-585.
- .Deng HW, Li J, Li JL, et al. Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int 1999;9(6):499-507.
- .D’Erasmo E, Ragno A, Raejntroph N, et al. [Drug-induced osteomalacia]. Recenti Prog Med 1998;89(10):529-533. [Italian] (Review)
- .Dennison EM, Arden NK, Keen RW, et al. Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol 2001;15(3):211-219.
- .Devgun MS, Paterson CR, Johnson BE, et al. Vitamin D nutrition in relation to season and occupation. Am J Clin Nutr 1981;34(8):1501-1504.
- .Dhesi JK, Bearne LM, Moniz C, et al. Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status. J Bone Miner Res 2002;17(5):891-897.
- .Dietrich T, Joshipura KJ, Dawson-Hughes B, et al. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr 2004;80(1):108-113.
- .Dodiuk-Gad RP, Rozen GS, Rennert G, et al. Sustained effect of short-term calcium supplementation on bone mass in adolescent girls with low calcium intake. Am J Clin Nutr 2005;81(1):168-174.
- .Donahue GJ, Waddell N, Plough AL, et al. The ABCDs of treating the most prevalent childhood disease. Am J Public Health 2005;95:1322-1324. (Editorial)
- .Elder GJ, Mackun K. 25-Hydroxyvitamin D deficiency and diabetes predict reduced BMD in patients with chronic kidney disease. J Bone Miner Res 2006;21(11):1778-1784.
- .Evio S, Tiitinen A, Laitinen K, et al. Effects of alendronate and hormone replacement therapy, alone and in combination, on bone mass and markers of bone turnover in elderly women with osteoporosis. J Clin Endocrinol Metab 2004;89(2):626-631.
- .Fahrleitner A, Dobnig H, Obernosterer A, et al. Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease. J Gen Intern Med 2002;17(9):663-669.
- .Farmer JA, Gotto AM Jr. Antihyperlipidaemic agents: drug interactions of clinical significance. Drug Saf 1994;11(5):301-309.
- .Farmer JA, Gotto AM Jr. Choosing the right lipid-regulating agent: a guide to selection. Drugs 1996;52(5):649-661.
- .Fenech M. Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food Chem Toxicol 2002;40(8):1113-1117. (Review)
- .Fenech M, Baghurst P, Luderer W, et al. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability: results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 2005;26(5):991-999.
- .Fenech M, Ferguson LR. Vitamins/minerals and genomic stability in humans. Mutat Res 2001;475(1-2):1-6.
- .Feskanich D, Willett WC, Colditz GA. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am J Clin Nutr 2003;77(2):504-511.
- .Finkelstein JS. Calcium plus vitamin D for postmenopausal women: bone appetit? N Engl J Med 2006;354(7):750-752. (Editorial)
- .Fleet JC. Genomic and proteomic approaches for probing the role of vitamin D in health. Am J Clin Nutr 2004;80:1730S-1734S.
- .Flicker L, Mead K, MacInnis RJ, et al. Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc 2003;51(11):1533-1538.
- .Food and Nutrition Board, Institute of Medicine. Vitamin D: dietary reference intakes: calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997:250-287. (National Academy Press)
- .Forero MS, Klein RF, Nissenson RA, et al. Effects of age on circulating immunoreactive and bioactive parathyroid hormone levels in women. J Bone Miner Res 1987;2:363-366.
- .Forman MR, Levin B. Calcium plus vitamin D3 supplementation and colorectal cancer in women. N Engl J Med 2006;354(7):752-754. (Editorial)
- .Fox J. Verapamil induces PTH resistance but increases duodenal calcium absorption in rats. Am J Physiol 1988;255(5):E702-707.
- .Gage BF, Birman-Deych E, Radford MJ, et al. Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation. Arch Intern Med 2006;166:241-246.
- .Gallagher JC, Riggs BL, DeLuca HF. Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 1980;51(6):1359-1364.
- .Garland C, Shekelle RB, Barrett-Connor E, et al. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1985;1(8424):307-309.
- .Garland CF, Garland FC, Gorham ED. Calcium and vitamin D: their potential roles in colon and breast cancer prevention. Ann N Y Acad Sci 1999;889:107-119. (Review)
- .Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006;96(2):252-261.
- .Garland CF, Gorham ED, Mohr SB, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol 2007;103(3-5):708-711.
- .Garrel D. Burn scars: a new cause of vitamin D deficiency? Lancet 2004;363(9405):259-260.
- .Gennari C. Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutr 2001;4(2B):547-559. (Review)
- .Gillespie WJ, Avenell A, Henry DA, et al. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis (Cochrane Review): update software. Issue 1. Oxford: The Cochrane Library, 2001.
- .Giovannucci E, Liu Y, Willett WC. Cancer incidence and mortality and vitamin D in black and white male health professionals. Cancer Epidemiol Biomarkers Prev. Epub ahead of print. 2006.
- .Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006;98(7):451-459.
- .Giovannucci E, Rimm EB, Wolk A, et al. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 1998;58(3):442-447.
- .Glerup H, Mikkelsen K, Poulsen L, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med 2000;247:260-268.
- .Gloth FM, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 1999;l3(1):5-7.
- .Godsall JW, Baron R, Insogna KL. Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia. Am J Med 1984;77(4):747-750.
- .Gong G, Johnson ML, Barger-Lux MJ, et al. Association of bone dimensions with a parathyroid hormone gene polymorphism in women. Osteoporos Int 1999;9(4):307-311.
- .Gonzalez AJ, White E, Kristal A, et al. Calcium intake and 10-year weight change in middle-aged adults. J Am Diet Assoc 2006;106(7):1066-1073.
- .Gordon CM, DePeter KC, Feldman HA, et al. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004;158:531-537.
- .Gorham ED, Garland CF, Garland FC, et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 2005;97(1-2):179-194.
- .Gorres B, Hollis B, et al. Low vitamin D status in rural and older populations with high body fat. Experimental Biology 2005 Meeting: San Diego, Apr 2, 2005.
- .Gough H, Goggin T, Bissessar A, et al. A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy. Q J Med 1986;59(230):569-577.
- .Grados F, Brazier M, Kamel S, et al. Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency. Joint Bone Spine 2003;70(3):203-208.
- .Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (randomised evaluation of calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005;365(9471):1621-1628.
- .Grant WB. An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates. Cancer 2002;94(1):272-281.
- .Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002;94(6):1867-1875.
- .Grant WB, Gorham ED. Commentary: time for public health action on vitamin D for cancer risk reduction. Int J Epidemiol 2006;35(2):224-225. (Editorial)
- .Grau MV, Baron JA, Sandler RS, et al. Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst 2003;95(23):1765-1771.
- .Greenspan SL, Parker RA, Fergusson L, et al. Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomized clinical trial. J Bone Miner Res 1998;13:1431-1438.
- .Greenspan SL, Rosen HN, Parker RA, et al. Early changes in serum N-telopeptide and C-telopeptide cross-linked collagen type 1 predict long-term response to alendronate therapy in elderly women. J Clin Endocrinol Metab 2000;85:3537-3540.
- .Greer FR. Issues in establishing vitamin D recommendations for infants and children. Am J Clin Nutr 2004;80:1759S-1762S.
- .Greer FR, Krebs NF; American Academy of Pediatrics Committee on nutrition. optimizing bone health and calcium intakes of infants, children, and adolescents. Pediatrics 2006;117(2):578-585.
- .Gross C, Stamey T, Hancock S, et al. Treatment of early recurrent prostate cancer with 1,25-dihydroxyvitamin D3 (calcitriol). J Urol 1998;159(6):2035-2039.
- .Gurkan F, Davutoglu M, Bosnak M, et al. Pamidronate treatment in acute vitamin D intoxication. J Endocrinol Invest 2004;27(7):680-682.
- .Hahn M, Lorez H, Fischer G. Effect of calcitriol in combination with corticosterone, interleukin-1beta, and transforming growth factor-beta1 on nerve growth factor secretion in an astroglial cell line. J Neurochem 1997;69(1):102-109.
- .Hamdy RC, Chesnut CH III, Gass ML, et al. Review of treatment modalities for postmenopausal osteoporosis. South Med J 2005;98(10):1000-1014. (Review)
- .Hamid Z, et al. Vitamin D deficiency in nursing home residents: need to adhere to current recommendations. Abstract C126. American Geriatrics Society 2005 Annual Meeting: Orlando, May 13, 2005.
- .Harkness L, Cromer B. Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females. Osteoporos Int 2005 Jan;16(1):109-113.
- .Harrell CC, Kline SS. Vitamin K-supplemented snacks containing olestra: implication for patients taking warfarin. JAMA 1999;282(12):1133-1134. (Letter)
- .Harris SS, Dawson-Hughes B, Perrone GA. Plasma 25-hydroxyvitamin D responses of younger and older men to three weeks of supplementation with 1800 IU/day of vitamin D. J Am Coll Nutr 1999;18:470-474.
- .Harris SS, Soteriades E, Coolidge JA, et al. Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. J Clin Endocrinol Metab 2000;85(11):4125-4130.
- .Harwood RH, Sahota O, Gaynor K, et al. A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: the Nottingham Neck of Femur (NONOF) Study. Age Ageing 2004;33(1):45-51.
- .Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 1985;44(1 Pt 1):124-129.
- .Hathcock JN, Shao A, Vieth R, et al. Risk assessment for vitamin D. Am J Clin Nutr 2007;85(1):6-18. (Review)
- .Hayes CE, Cantorna MT, Deluca HF. Vitamin D and multiple sclerosis. Proc Soc Exp Biol Med 1997;216:21-27. (Review)
- .Heaney RP. Barriers to optimizing vitamin D3 intake for the elderly. J Nutr 2006;136(4):1123-1125.
- .Heaney RP. BMD: the problem. Osteoporos Int 2005;16:1013-1015.
- .Heaney RP. Bone mineral content, not bone mineral density, is the correct bone measure for growth studies. Am J Clin Nutr 2003;78(2):350-352.
- .Heaney RP. Constructive interactions among nutrients and bone-active pharmacologic agents with principal emphasis on calcium, phosphorus, vitamin D and protein. J Am Coll Nutr 2001;20(5 Suppl):403S-409S;417S-420S.
- .Heaney RP. Design considerations for clinical investigations of osteoporosis. In: Marcus R, Feldman D, Nelson D, et al, eds. Osteoporosis. 3rd ed. San Diego: Elsevier, Inc; 2007. In press.
- .Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 2004;80:1706S-1709S.
- .Heaney RP. Human serum 25-hydroxy-cholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77:204-210.
- .Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003;78(5):912-919. (Review)
- .Heaney RP. Phosphorus nutrition and the treatment of osteoporosis. Mayo Clin Proc 2004;79(1):91-97. (Review)
- .Heaney RP. The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 2005;97(1-2):13-19. (Review)
- .Heaney RP. Vitamin D, nutritional deficiency, and the medical paradigm. J Clin Endocrinol Metab 2003;88(11):5107-5108. (Review)
- .Heaney RP, Bachmann GA. Interpreting studies of nutritional prevention: a perspective using calcium as a model. J Womens Health 2005;14:990-897.
- .Heaney RP, Dowell MS, Hale CA, et al. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22(2):142-146.
- .Heaney RP, Draper MW. Raloxifene and estrogen: comparative bone-remodeling kinetics. J Clin Endocrinol Metab 1997;82(10):3425-3429.
- .Heaney RP, Magowan S, Zhous S. Prevalence of low calcium intake in postmenopausal osteoporotic women: the need for supplementation. Abstract M276. American Society of Bone and Mineral Research (ASBMR) 27th Annual Meeting: Nashville, Sep 26, 2005.
- .Heaney RP, Rafferty K, Dowell MS, et al. Calcium fortification systems differ in bioavailability. J Am Diet Assoc 2005;105(5):807-809.
- .Heaney RP, Weaver CM. Calcium and vitamin D. Endocrinol Metab Clin North Am 2003;32(1):181-94, vii-viii. (Review)
- .Hendler SS, Rorvik DR, eds. PDR for nutritional supplements. Montvale, NJ: Medical Economics Company, Inc; 2001.
- .Henning HV. Aluminum toxicity. Klin Wochenschr 1989;67(24):1221-1228. [German]
- .Hewison M, O’Riordan JL. Hormone-nuclear receptor interactions in health and disease: vitamin D resistance. Baillieres Clin Endocrinol Metab 1994;8(2):305-315.
- .Hiatt RA, Krieger N, Lobaugh B, et al. Prediagnostic serum vitamin D and breast cancer. J Natl Cancer Inst 1998;90(6):461-463.
- .Hodges R. Drug-nutrient interaction. In: Nutrition in medical practice. Philadelphia: Saunders; 1980:323-331.
- .Hodis HN, Mack WJ, LaBree L, et al. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 1995;273(23):1849-1854.
- .Holick MF. High prevalence and clinical implications of vitamin D inadequacy. Mayo Clin Proc 2006;81(3):353-373. (Review)
- .Holick MF. PTH (1-34): a novel anabolic drug for the treatment of osteoporosis. South Med J 2005;98(11):1114-1117. (Review)
- .Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80:1678S-1688S.
- .Holick MF. The parathyroid hormone D-lema. J Clin Endocrinol Metab 2003;88(8):3499-3500. (Comment)
- .Holick MF. The vitamin D epidemic and its health consequences. J Nutr 2005;135(11):2739S-2748S.
- .Holick MF. Vitamin D. In: Shils M, Olson JA, Shike M, et al, eds. Nutrition in health and disease. 9th ed. Baltimore: Williams & Wilkins; 1999:329-345.
- .Holick MF. Vitamin D: a millenium perspective. J Cell Biochem 2003;88(2):296-307. (Review)
- .Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 2005;98(10):1024-1027. (Review)
- .Holick MF. Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In: Favus M, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 1999:92-98.
- .Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004;79:362-371. (Review)
- .Holick MF. Vitamin D deficiency: what a pain it is. Mayo Clin Proc 2003;78(12):1457-1459. (Comment)
- .Holick MF, Krane SM, Potts JT. Calcium, phosphorus, and bone metabolism: calcium-regulating hormones. In: Fauci AS, Braunwald E, Isselbacher KJ, et al, eds. Harrison’s principles of internal medicine. 14th ed. New York: McGraw-Hill Companies Health Professional Division; 1998:2221-2222.
- .Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317-322.
- .Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr 2004;79:717-726.
- .Hollis BW, Wagner CL. Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Clin Nutr 2004;80:1752S-1758S.
- .Holmes RP, Kummerow FA. The relationship of adequate and excessive intake of vitamin D to health and disease. J Am Coll Nutr 1983;2(2):173-199. (Review)
- .Holt PR, Arber N, Halmos B, et al. Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D. Cancer Epidemiol Biomarkers Prev 2002;11(1):113-119.
- .Hoogwerf BJ, Hibbard DM, Hunninghake DB. Effects of long-term cholestyramine administration on vitamin D and parathormone levels in middle-aged men with hypercholesterolemia. J Lab Clin Med 1992;119(4):407-411.
- .Huang SP, Huang CY, Wu WJ, et al. Association of vitamin D receptor FokI polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostatectomy. Int J Cancer 2006;119(8):1902-1907.
- .Hudson JQ, Small RE, Buckley L. Perceptions of pharmacists about adverse effects of corticosteroid therapy: focus on osteoporosis. J Am Pharm Assoc (Wash) 1998;38(6):710-716.
- .Humbert P, Dupond JL, Agache P, et al. Treatment of scleroderma with oral 1,25-dihydroxyvitamin D3: evaluation of skin involvement using non-invasive techniques: results of an open prospective trial. Acta Derm Venereol 1993;73(6):449-451.
- .Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358(9292):1500-1503.
- .Iivanainen M, Savolainen H. Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. Acta Neurol Scand Suppl 1983;97:49-67.
- .Ikeda Y, Takemoto F. [Serum calcium concentration and the safety of vitamin D therapy.] Clin Calcium 2004;14(9):79-82. [Japanese] (Review)
- .Iqbal SJ, Taylor WH. Treatment of vitamin D2 poisoning by induction of hepatic enzymes. Br Med J 1982;285:541-542.
- .Ismail F, Corder CN, Epstein S, et al. Effects of pravastatin and cholestyramine on circulating levels of parathyroid hormone and vitamin D metabolites. Clin Ther 1990;12(5):427-430.
- .Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354(7):669-683. Erratum in N Engl J Med 2006;354(10):1102.
- .Jahnsen J, Falch JA, Mowinckel P, et al. Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease. Scand J Gastroenterol 2002;37(2):192-199.
- .Janeway CA, Travers P. Immunobiology: the immune system in health and disease. 3rd ed. New York: Garland Publishing Inc; 1997.
- .Jänne PA, Mayer RJ. Chemoprevention of colorectal cancer. N Engl J Med 2000;342(26):1960-1968.
- .Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr 2002;75(4):611-615.
- .Janowsky EC, Lester GE, Weinberg CR, et al. Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutr 1999;2(3):283-291.
- .Javaid MK, Crozier SR, Harvey NC, et al. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 2006;367:36-43.
- .John EM, Dreon DM, Koo J, et al. Residential sunlight exposure is associated with a decreased risk of prostate cancer. J Steroid Biochem Mol Biol 2004;89-90(1-5):549-552.
- .John EM, Schwartz GG, Dreon DM, et al. Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992: National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 1999;8(5):399-406.
- .John EM, Schwartz GG, Koo J, et al. Sun exposure, vitamin d receptor gene polymorphisms, and risk of advanced prostate cancer. Cancer Res 2005;65(12):5470-5479.
- .John WG, Noonan K, Mannan N, et al. Hypovitaminosis D is associated with reductions in serum apolipoprotein A-I but not with fasting lipids in British Bangladeshis. Am J Clin Nutr 2005;82:517-522.
- .Jones G, Sambrook PN. Drug-induced disorders of bone metabolism: incidence, management and avoidance. Drug Saf 1994;10(6):480-489.
- .Kamio A, Kummerow F, Imai H. Degeneration of aortic smooth muscle cells in swine fed excess vitamin D3. Arch Pathol Lab Med 1977;101:378-381.
- .Kampman E, Slattery ML, Caan B, et al. Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control 2000:11:459-466.
- .Kamradt J, Rafi L, Mitschele T, et al. Analysis of the vitamin D system in cutaneous malignancies. Recent Results Cancer Res 2003;164:259-269.
- .Kano K, Suda T. Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration. Eur J Pediatr 1982;138(2):162-165.
- .Keranen T, Sivenius J. Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. Acta Neurol Scand Suppl 1983;97:69-80.
- .Kesse E, Boutron-Ruault MC, Norat T, et al. Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 2005;117(1):137-144.
- .Kim JG, Lim KS, Kim EK, et al. Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause 2001;8(3):222-228.
- .Kinjo M, Setoguchi S, Schneeweiss S, et al. Bone mineral density in subjects using central nervous system-active medications. Am J Med 2005;118(12):1414.
- .Klein GL, Chen TC, Holick ME, et al. Synthesis of vitamin D in skin after burns. Lancet 2004;363(9405):291-292.
- .Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2(1):10-32.
- .Kovacs CS, Jones G, Yendt ER. Primary hyperparathyroidism masked by antituberculous therapy-induced vitamin D deficiency. Clin Endocrinol (Oxf) 1994;41(6):831-836.
- .Kragballe K. Treatment of psoriasis by the topical application of the novel cholecalciferol analogue calcipotriol. Arch Dermatol 1989;125(12):1647-1652.
- .Krall EA, Wehler C, Garcia RI, et al. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001;111(6):452-456.
- .Kristjansson K, Rut AR, Hewison M, et al. Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3. J Clin Invest 1993;92:12-16.
- .Kristal AR, Cohen JH, Qu P, et al. Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11(8):719-725.
- .Kummerow FA, Cho BH, Huang WY, et al. Additive risk factors in atherosclerosis. Am J Clin Nutr 1976;29(5):579-584.
- .Kyriakidou-Himonas M, Aloia JF, Yeh JK. Vitamin D supplementation in postmenopausal black women. J Clin Endocrinol Metab 1999;84:3988-3990.
- .Labriji-Mestaghanmi H, Billaudel B, Garnier PE, et al. Vitamin D and pancreatic islet function: I: time course for changes in insulin secretion and content during vitamin D deprivation and repletion. J Endocrinol Invest 1988;11(8):577-584.
- .Labriji-Mestaghanmi H, Billaudel B, Garnier PE, et al. Vitamin D and pancreatic islet function: 2: time course for changes in insulin secretion and content during vitamin D deprivation and repletion. J Endocrinol Invest 1988;11:584-587.
- .Ladhani S, Srinivasan L, Buchanan C, et al. Presentation of vitamin D deficiency. Arch Dis Child 2004;89(8):781-784.
- .Lane NE, Gore R, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Arthritis Rheum 1999;42(5):854-860.
- .Langman M, Boyle P, et al. Chemoprevention of colorectal cancer. Gut 1998;43:578-585.
- .Lanou AJ, Berkow SE, Barnard ND. Calcium, dairy products, and bone health in children and young adults: a reevaluation of the evidence. Pediatrics 2005;115(3):736-743. (Review)
- .Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998;135(4):319-323.
- .Lappe JM, Davies KM, Travers-Gustafson D, et al. Vitamin D status in a rural postmenopausal female population. J Am Coll Nutr 2006;25(5):395-402.
- .Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risks: results of a randomized trial. Am J Clin Nutr 2007;85(6):1586-1591.
- .Latham NK, Anderson CS, Reid IR. Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review. J Am Geriatr Soc 2003;51(9):1219-1226.
- .Lau KH, Baylink DJ. Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy. Calcif Tissue Int 1999;65(4):295-306.
- .LeBoff MS, Kohlmeier L, Hurwitz S, et al. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 1999;281:1505-1511.
- .Lee C, Majka DS. Is calcium and vitamin D supplementation overrated? J Am Diet Assoc 2006;106(7):1032-1034.
- .Lehmann B, Querings K, Reichrath J. Vitamin D and skin: new aspects for dermatology. Exp Dermatol 2004;13(s4):11-15. (Review)
- .Lemaire V, Miravet L, Bordier P, et al. [Osteomalacy induced by anticonvulsants: one case with a study of vitamin D metabolism.] Nouv Presse Med 1975;4(44):3121-3124. [French]
- .Leonard MB, Feldman HI, Shults J, et al. Long-term, high-dose glucocorticoids and bone mineral content in childhood glucocorticoid-sensitive nephrotic syndrome. N Engl J Med 2004;351(9):868-875.
- .Letsou AP, Price LS. Health aging and nutrition: an overview. Clin Geriatr Med 1987;3(2):253-260.
- .Lieberman DA, Prindiville S, Weiss DG, et al. Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA 2003;290:2959-2967.
- .Lilliu H, Pamphile R, Chapuy MC, et al. Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention. Maturitas 2003;44(4):299-305.
- .Lind L, Skarfors E, Berglund L, et al. Serum calcium: a new, independent prospective risk factor for myocardial infarction in middle-aged men followed for 18 years. J Clin Epidemiol 1997;50(8):967-973.
- .Lips P, Chapuy MC, Dawson-Hughes B, et al. An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos Int 1999;9(5):394-397.
- .Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Ann Intern Med 1996;124(4):400-406.
- .Liu RH, Albrecht J, Werth VP. Cross-sectional study of bisphosphonate use in dermatology patients receiving long-term oral corticosteroid therapy. Arch Dermatol 2006;142:37-41.
- .Livingston S, Berman W. Antiepileptic drugs and development of rickets. J Pediatr 1973;82(2):347-348.
- .Livingston S, Berman W, Pauli LL. Letter: anticonvulsant drugs and vitamin D metabolism. JAMA 1973;226(7):787. (Letter)
- .Livingston S, Berman W, Pauli LL. Anticonvulsant drugs and vitamin D metabolism. JAMA 1973;224(12):1634-1635.
- .Livingston S, Pauli LL, Bowden AN. Letter: anticonvulsants and vitamin D metabolism. Dev Med Child Neurol 1974;16(5):683-684. (Letter)
- .Lochner JD, Schneider DJ. The relationship between tuberculosis, vitamin D, potassium and AIDS: a message for South Africa? S Afr Med J 1994;84(2):79-82. [Afrikaans]
- .Lokeshwar BL, Schwartz GG, Selzer MG, et al. Inhibition of prostate cancer metastasis in vivo: a comparison of ,23-dihydroxyvitamin D (calcitriol) and EB1089. Cancer Epidemiol Biomarkers Rev 1999;8(3):241-248.
- .Lukaszkiewicz J. Vitamin D intoxication: a second view. Pediatrics 2006Feb 27. (Letter). Available at: http://pediatrics.aappublicatons.org/cgi/eletters/116/3/e453#1707. Accessed December 12, 2006.
- .Lukaszkiewicz J, Prószyñska K, Lorenc RS, et al. Hepatic microsomal enzyme induction: treatment of vitamin D poisoning in a 7 month old baby. Br Med J 1987;295:1173.
- .Lund B, Andersen RB, Friis T, et al. Effect of 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on intestine and bone in glucocorticoid-treated patients. Clin Endocrinol (Oxf) 1977;7(Suppl):177s-181s.
- .Macallan DC, Maxwell JD, Eastwood JB. Osteomalacia should be sought and treated before withdrawal of anticonvulsant therapy in UK Asians. Postgrad Med J 1992;68(796):134-136.
- .Maclaren N, Lifshitz F. Vitamin D-dependency rickets in institutionalized, mentally retarded children on long term anticonvulsant therapy: II: the response to 25-hydroxycholecalciferol and to vitamin D2. Pediatr Res 1973;7(11):914-922.
- .Major GC, Alarie F, Dore J, et al. Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am J Clin Nutr 2007;85(1):54-60.
- .Makishima M, Lu TT, Xie W, et al. Vitamin D receptor as an intestinal bile acid sensor. Science 2002;296(5571):1313-1316.
- .Malabanan AO, Holick MF. Vitamin D and bone health in postmenopausal women. J Womens Health (Larchmt) 2003;12(2):151-156. (Review)
- .Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998;351(9105):805-806.
- .Malavolta N, Pratelli L, Frigato M, et al. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women. Osteoporos Int 2005;16(12):1691-1697.
- .Malloy PJ, Eccleshall TR, Gross C, et al. Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness. J Clin Invest 1997;99:297-304.
- .Manolagas SC, Jilka RL. Emerging insights into the patho-physiology of osteoporosis. N Engl J Med 1995;332:305-311.
- .Marc J, Prezelj J, Komel R, et al. Association of vitamin D receptor gene polymorphism with bone mineral density in Slovenian postmenopausal women. Gynecol Endocrinol 2000;14(1):60-64.
- .Martinez ME, Giovannucci EL, Colditz GA, et al. Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 1996;88(19):1375-1382.
- .Matkovic V, Goel PK, Badenhop-Stevens NE, et al. Calcium supplementation and bone mineral density in females from childhood to young adulthood: a randomized controlled trial. Am J Clin Nutr 2005;81(1):175-188.
- .Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther 1982;4(6):423-440.
- .Matsunaga S, Ito H, Sakou T. The effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Calcif Tissue Int 1999;65(4):285-289.
- .Mazess RB, Elangovan L. A review of intravenous versus oral vitamin D hormone therapy in hemodialysis patients. Clin Nephrol 2003;59(5):319-325. (Review)
- .McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake of serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study. Ann Intern Med 1996;125:353-359.
- .McClung MR, San Martin J, Miller PD, et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med 2005;165:1762-1768.
- .McCullough ML, Robertson AS, Rodriguez C, et al. Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). Cancer Causes Control 2003;14(1):1-12.
- .McMurray DN, Bartow RA, Mintzer CL, et al. Micronutrient status and immune function in tuberculosis. Ann N Y Acad Sci 1990;587:59-69.
- .Meier C, Woitge HW, Witte K, et al. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res 2004;19(8):1221-1230.
- .Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: Results from the Iowa Women’s Health Study. Arthritis Rheum 2004;50(1):72-77.
- .Mezquita Raya P, Munoz Torres M, Lopez Rodriguez F, et al. Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity. Med Clin (Barc) 2002;119(3):85-89.
- .Mezquita-Raya P, Munoz-Torres M, Luna JD, et al. Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res 2001;16(8):1408-1415.
- .Meunier P. Prevention of hip fractures by correcting calcium and vitamin D insufficiencies in elderly people. Scand J Rheumatol Suppl 1996;103:75-80.
- .Michaëlsson K, Melhus H, Bellocco R, et al. Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. Bone 2003;32(6):694-703.
- .Mimaki T, Walson PD, Haussler MR. Anticonvulsant therapy and vitamin D metabolism: evidence for different mechanisms for phenytoin and phenobarbital. Pediatr Pharmacol (N Y) 1980;1(2):105-112.
- .Mohan HK, Groves AM, Fogelman I, et al. Thyroid hormone and parathyroid hormone competing to maintain calcium levels in the presence of vitamin D deficiency. Thyroid 2004 14(9):789-791.
- .Mocanu V, Stitt PA, Costan AR, et al. Long term efficacy and safety of high vitamin D intakes as fortified bread. FASEB J 2005;19(4;Part 1;Suppl S):A59.
- .Mocanu V, Stitt PA, Costan AR, et al. Long-term efficacy and safety of high vitamin D intakes as fortified bread. A59. Experimental Biology 2005 Meeting. San Diego, Apr 2, 2005.
- .Moore CE, Murphy MM, Holick MF. Population-based study of vitamin D intake in the United States. Experimental Biology 2005 Meeting. San Diego, Apr 2, 2005.
- .Moore C, Murphy MM, Keast DR, et al. Vitamin D intake in the United States. J Am Diet Assoc 2004;104(6):980-983.
- .Morimoto S, Yoshikawa K, Fukuo K, et al. Inverse relation between severity of psoriasis and serum 1,25-dihydroxy-vitamin D level. J Dermatol Sci 1990;1(4):277-282.
- .Motohashi Y, Yamada S, Yanagawa T, et al. Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. J Clin Endocrinol Metab 2003;88(7):3137-3140.
- .Moyad MA. Osteoporosis. Part III: not just for bone loss: potential benefits of calcium and vitamin D for overall general health. Urol Nurs 2003;23(1):69-74.
- .Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296:2832-2838.
- .Munger KL, Zhang SM, O’Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62:60-65.
- .Myrianthopoulos M. Dietary treatment of hyperlipidemia in the elderly. Clin Geriatr Med 1987;3(2):343-359.
- .National Institutes of Health, Office of Dietary Supplements. Facts about dietary supplements: vitamin D. 2002. Available at: http://www.cc.nih.gov/ccc/supplements/vitd.html. Accessed January 14, 2004.
- .Nelson JB, et al. Once weekly oral alendronate prevents bone loss in men on androgen deprivation therapy for prostate cancer. Abstract 139. ASCO/ASTRO Prostate Cancer Symposium. San Francisco, Feb 28, 2006.
- .Nelson-Piercy C. Heparin-induced osteoporosis in pregnancy. Lupus 1997;6(6):500-504. (Review)
- .Nesbitt LT Jr. Minimizing complications from systemic glucocorticosteroid use. Dermatol Clin 1995;13(4):925-939. (Review)
- .Nicar MJ, Pak CY. Calcium bioavailability from calcium carbonate and calcium citrate. J Clin Endocrinol Metab 1985;61(2):391-393.
- .Nordin BEC, Need AG, Chatterton BE, et al. The relative contribution of age and years since menopause to post-menopausal bone loss. J Clin Endocrinol Metab 1990;70:83-88.
- .Nowson CA, Sherwin AJ, McPhee JG, et al. Energy, protein, calcium, vitamin D and fibre intakes from meals in residential care establishments in Australia. Asia Pac J Clin Nutr 2003;12(2):172-177.
- .Nuti R, Vattimo A, Turchetti V, et al. 25-Hydroxycholecalciferol as an antagonist of adverse corticosteroid effects on phosphate and calcium metabolism in man. J Endocrinol Invest 1984;7(5):445-448.
- .O’Connell MB, Madden DM, Murray AM, et al. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med 2005;118(7):778-781.
- .O’Neill S, MacLennan A, Bass S, et al. Guidelines for the management of postmenopausal osteoporosis for GPs. Aust Fam Physician 2004;33(11):910-919.
- .O’Regan S, Chesney RW, Hamstra A, et al. Reduced serum 1,25-(OH)2 vitamin D3 levels in prednisone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand 1979;68(1):109-111.
- .Orwoll E, Meier D. Alterations in calcium, vitamin D and para-thyroid hormone physiology in normal men with aging: relationship to the development of senile osteoporosis. J Clin Endocrinol Metab 1986;63:1262-1269.
- .Osborne JL, Schwartz GG, Smith DC, et al. Phase II trial of oral 1,25 dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer. Urol Oncol 1995;1:195.
- .Outila TA, Karkkainen MU, Lamberg-Allardt CJ. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am J Clin Nutr 2001;74(2):206-210.
- .Palmieri GM, Thompson JS, Eliel LP. Modifications of plasma magnesium by thyrocalcitonin, parathyroid extract and cortisone. Endocrinology 1969;84(6):1509-1511.
- .Pappa HM, Gordon CM, Saslowsky TM, et al. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics 2006;118(5):1950-1961.
- .Parikh S. High prevalence of vitamin D insufficiency in obese African American subjects. Abstract P3-467. Endocrine Society’s 85th Annual Meeting. Philadelphia, Jun 21, 2003.
- .Pawley N, Bishop NJ. Prenatal and infant predictors of bone health: the influence of vitamin D. Am J Clin Nutr 2004;80:1748S-1751S.
- .Peacey SR, Wright D, Harries MJ. Failure to normalize parathyroid hormone during treatment of vitamin D deficiency in Asian patients. Clin Endocrinol (Oxf) 2004;61(5):603-606.
- .Pelton R, La Valle JB, Hawkins EB, et al. Drug-induced nutrient depletion handbook. Hudson, OH: Lexi-Comp, Inc; 1999-2000.
- .Peters U, McGlynn KA, Chatterjee N, et al. Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas. Cancer Epidemiol Biomarkers Prev 2001;10(12):1267-1274.
- .Pettifor JM. Nutritional rickets: deficiency of vitamin D, calcium, or both? Am J Clin Nutr 2004;80:1725S-1729S.
- .Pettifor JM, Bikle DD, Cavaleros M, et al. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med 1995;122(7):511-513.
- .Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001;86(4):1633-1637.
- .Pittas A, et al. A prospective study of vitamin D Intake and risk of type 2 diabetes in women. Abstract 1772. Sixty-fifth Scientific Sessions of the American Diabetes Association: San Diego, Jun 13, 2005.
- .Pittas A, Dawson-Hughes B, Li T, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006;29:650-656.
- .Plotnikoff GA. Vitamin D: the steroid hormone prescription for every patient. Minn Med 2003;86(1):43-45. (Review)
- .Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003;78(12):1463-1470.
- .Pluskiewicz W, Nowakowska J. Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanges. Ultrasound Med Biol 1997;23(4):553-558.
- .Porthouse J, Cockayne S, King C, et al. Randomised controlled trial of vitamin supplementation with calcium and cholecalciferol (vitamin D) for prevention of fractures in primary care. BMJ 2005;330(7498):1003-1006.
- .Potter JD. Nutrition and colorectal cancer. Cancer Causes Control 1996;7:127-146.
- .Prentice A, Ginty F, Stear SJ, et al. Calcium supplementation increases stature and bone mineral mass of 16-18 year old boys. J Clin Endocrinol Metab 2005;90:3153-3161.
- .Prentice A, Parsons TJ, Cole TJ. Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 1994;60:837-842.
- .Prince RL, Devine A, Dhaliwal SS, et al. Effects of calcium supplementation on clinical fracture and bone structure. results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006;166:869-875.
- .Raiten DJ, Picciano MF. Vitamin D and health in the 21st century: bone and beyond: executive summary. Am J Clin Nutr 2004;80:1673S-1677S.
- .Raloff J. Bread and chocolate, no longer D-minimus. Sci News Online 2005;167(19).
- .Rao A, Woodruff RD, Wade WN, et al. Genistein and vitamin D synergistically inhibit human prostatic epithelial cell growth. J Nutr 2002;132(10):3191-3194.
- .Rassouli A, Milanian I, Moslemi-Zadeh M. Determination of serum 25-hydroxyvitamin D(3) levels in early postmenopausal Iranian women: relationship with bone mineral density. Bone 2001;29(5):428-430.
- .Recker RR, Hinders S, Davies KM, et al. Correcting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner Res 1996;11:1961-1966.
- .Reichrath J. Will analogs of 1,25-dihydroxyvitamin D(3) (calcitriol) open a new era in cancer therapy? Onkologie 2001;24(2):128-133. (Review)
- .Reid IR, Ames RW, Evans MC, et al. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. Am J Med 1995;98:331-335.
- .Reid IR, Ibbertson HK. Calcium supplements in the prevention of steroid-induced osteoporosis. Am J Clin Nutr 1986;44(2):287-290.
- .Reid IR, Ibbertson HK. Corticosteroids and osteoporosis. Aust N Z J Med 1987;17(6):611-612. (Letter)
- .Riggs BL, Melton LJ. The prevention and treatment of osteoporosis. N Engl J Med 1992;327(9):620-627.
- .Ringe JD, Becker K. [Osteoporosis caused by long term heparin therapy.] Med Monatsschr Pharm 1985;8(3):80-83. [German]
- .Rodbro P, Christiansen C. Letter: prophylactic vitamin D supplement to epileptic children on anticonvulsant drugs. N Engl J Med 1975;293(6):306-307. (Letter)
- .Roe DA. Diet and drug interactions. New York: Van Nostrand Reinhold; 1989. (Review)
- .Roe DA. Drug-induced nutritional deficiencies. 2nd ed. Westport, CT: Avi Publishing; 1985:158-159. (Review)
- .Roe DA. Risk factors in drug-induced nutritional deficiencies. In: Roe DA, Campbell T, eds. Drugs and nutrients: the interactive effects. New York: Marcel Decker; 1984:505-523. (Review)
- .Rook GA, Steele J, Fraher L, et al. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986;57(1):159-163.
- .Rucker D, Allan JA, Fick GH, et al. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 2002;166(12):1517-1524. Erratum in CMAJ 2002;167(8):850.
- .Rude RK, Gruber HE, Oldham SB. Cortisone-induced osteoporosis: effects on bone adenylate cyclase. Miner Electrolyte Metab 1993;19(2):71-77.
- .Rupp WM, McCarthy HB, Rohde TD, et al. Risk of osteoporosis in patients treated with long-term intravenous heparin therapy. Curr Surg 1982;39(6):419-422.
- .Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112(4):458-463.
- .Sahota O, Mundey MK, San P, et al. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 2004;35(1):312-319.
- .Salamoun MM, Kizirian AS, Tannous RI, et al. Low calcium and vitamin D intake in healthy children and adolescents and their correlates. Eur J Clin Nutr 2005;59(2):177-184.
- .Sambrook PN. Glucocorticoid osteoporosis. Curr Pharm Des 2002;8(21):1877-1883. (Review)
- .Sambrook P. Vitamin D and fractures: quo vadis? Lancet 2005;365(9471):1599-1600. (Editorial)
- .Sasidharan PK, Rajeev E, Vijayakumari V. Tuberculosis and vitamin D deficiency. J Assoc Physicians India 2002;50:554-558.
- .Sato Y, Kanoko T, Satoh K, et al. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer’s disease. Bone 2005;36(1):61-68.
- .Sato Y, Kanoko T, Satoh K, et al. The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Alzheimer disease: a randomized controlled trial. Arch Intern Med 2005;165:1737-1742.
- .Saul AW. Vitamin D: deficiency, diversity and dosage. J Orthomolecular Med 2003;18(3-4):194-204
- .Schacht E, Richy F, Reginster JY. The therapeutic effects of alfacalcidol on bone strength, muscle metabolism and prevention of falls and fractures. J Musculoskeletal Neuronal Interact 2005;5(3):273-284. (Review)
- .Schaefer K, von Herrath D, Kraft D. Disordered calcium metabolism during anticonvulsant treatment. Geriatr Med 1973;3(3-4):140-144. (Review)
- .Schlagheck TG, Riccardi KA, Zorich NL, et al. Olestra dose response on fat-soluble and water-soluble nutrients in humans. J Nutr 1997;127(8 Suppl):1646S-1665S.
- .Schleithoff SS, Zittermann A, Tenderich G, et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006;83:754-759.
- .Schousboe JT, Nyman JA, Kane RL, et al. Cost-effectiveness of alendronate therapy for osteopenic postmenopausal women. Ann Intern Med 2005;142(9):734-741.
- .Schumann K. Interactions between drugs and vitamins at advanced age. Int J Vitam Nutr Res 1999;69(3):173-178.
- .Schwartz GG, Blot WJ. Vitamin D status and cancer incidence and mortality: something new under the sun. J Natl Cancer Inst 2006;98(7):428-430. (Editorial)
- .Schwartz GG, Eads D, Rao A, et al. Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis 2004;25(6):1015-1026.
- .Scragg R, Khaw K-T, Murphy S. Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. Eur J Clin Nutr 1995;49:640-646.
- .Selby PL, Davies M, Marks JS. Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate. Clin Endocrinol (Oxf) 1995;43(5):531-536.
- .Self TH, Chrisman CR, Baciewicz AM, et al. Isoniazid drug and food interactions. Am J Med Sci 1999;317(5):304-311.
- .Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. Am J Med 1991;91(2):151-155.
- .Semba RD, Garrett E, Johnson BA, et al. Vitamin D deficiency among older women with and without disability. Am J Clin Nutr 2000;72:1529-1534.
- .Service FJ. Idle thoughts from an addled mind. Endocr Pract 2002;8:135-136.
- .Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41(06):1125-1129.
- .Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc 1997;56(3):915-937. (Review)
- .Shiota E, Tsuchiya K, Yamaoka K, et al. Effect of intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis. J Orthop Sci 2001;6(2):133-136.
- .Silverberg SL, Shane E, Dempster DW, et al. The effects of vitamin D insufficiency in patients with primary hyperparathyroidism. Am J Med 1999;107:561-567.
- .Siris ES. Utilization and correlates of osteoporosis treatment in postmenopausal women: observations from the National Osteoporosis Risk Assessment (NORA). Abstract M378. American Society for Bone and Mineral Research (ASBMR) 27th Annual Meeting. Nashville, Sep 26, 2005.
- .Siwinska A, Opolski A, Chrobak A, et al. Potentiation of the antiproliferative effect in vitro of doxorubicin, cisplatin and genistein by new analogues of vitamin D. Anticancer Res 2001;21(3B):1925-1929.
- .Skalska A, Gasowski J, Stepniewski M, et al. Antioxidative protection in hypertensive patients treated with diuretics. Am J Hypertens 2005;18(8):1130-1132.
- .Slatter ML, Yakumo K, Hoffman M, et al. Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control 2001;12(4):359-364.
- .Souberbielle JC, Cormier C, Kindermans C, et al. Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. J Clin Endocrinol Metab 2001;86(7):3086-3090.
- .Sowers MF, Lachance L. Vitamins and arthritis: the roles of vitamins A, C, D, and E. Rheum Dis Clin North Am 1999;25(2):315-331.
- .Specker B. Vitamin D requirements during pregnancy. Am J Clin Nutr 2004;80:1740S-1747S.
- .Staberg B, OxholmA, Klemp P, et al. Abnormal vitamin D metabolism in patients with psoriasis. Acta Derm Venereol 1987;67(1):65-68.
- .Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1999:282.
- .Steinbuch M, Youket TE, Cohen S. Oral glucocorticoid use is associated with an increased risk of fracture. Osteoporos Int 2004;15(4):323-328.
- .Steingrimsdottir L, Gunnarsson O, Indridason OS, et al. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005;294:2336-2341.
- .Stockley IH. Drug interactions. 6th ed. London: Pharmaceutical Press; 2002.
- .Stogmann W. [Disorders of calcium metabolism and ossification caused by anticonvulsants.] Padiatr Padol 1983;18(2):119-121. [German]
- .Summey BT, Yosipovitch G. Glucocorticoid-induced bone loss in dermatologic patients: an update. Arch Dermatol 2006;142:82-90. (Review)
- .Takeda E, Yamamoto H, Taketani Y, et al. Vitamin D-dependent rickets type I and type II. Acta Paediatr Jpn 1997;39(4):508-513.
- .Tam CS, Wilson DR, Hitchman AJ, et al. Protective effect on vitamin D2 on bone apposition from the inhibitory action of hydrocortisone in rats. Calcif Tissue Int 1981;33(2):167-172.
- .Tangpricha V, Pearce EN, Chen TC, et al. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002;112(8):659-662.
- .Teegarden D, Legowski P, Gunther CW, et al. Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss. J Clin Endocrinol Metab 2005;90(9):5127-5133.
- .Teucher B, Majsak-Newman G, Dainty JR, et al. Calcium absorption is not increased by caseinophosphopeptides. Am J Clin Nutr 2006;84:162-166.
- .The North American Menopause Society. The role of calcium in peri- and postmenopausal women: 2006 position statement of The North American Menopause Society. Menopause 2006;13(6):859-862.
- .Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med 1998;338(12):777-783.
- .Thornquist MD, Kristal AR, Patterson RE, et al. Olestra consumption does not predict serum concentrations of carotenoids and fat-soluble vitamins in free-living humans: early results from the sentinel site of the olestra post-marketing surveillance study. J Nutr 2000;130(7):1711-1718.
- .Threlkeld DS, ed. Blood modifiers, anticoagulants, heparin. In: Facts and comparisons drug information. St Louis: Facts and Comparisons; 1997.
- .Threlkeld DS, ed. Diuretics and cardiovasculars, calcium channel blocking agents. In: Facts and comparisons drug information. St Louis: Facts and Comparisons; 1992.
- .Threlkeld DS, ed. Hormones, adrenal cortical steroids, glucocorticoids. In: Facts and comparisons drug information. St Louis: Facts and Comparisons; 1991.
- .Tjellesen L, Hummer L, Christiansen C, et al. Different metabolism of vitamin D2/D3 in epileptic patients treated with phenobarbitone/phenytoin. Bone 1986;7(5):337-342.
- .Tomita S, Ohnishi J, Nakano M, et al. The effects of anticonvulsant drugs on vitamin D3-activating cytochrome P-450-linked monooxygenase systems. J Steroid Biochem Mol Biol 1991;39(4A):479-485.
- .Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326(7387):469-472.
- .Trovato A, Nuhlicek DN, Midtling JE. Drug-nutrient interactions. Am Fam Physician 1991;44(5):1651-1658. (Review)
- .Tsang RC, Roginsky MS, Mellies MJ, et al. Plasma 25-hydroxy-vitamin D in familial hypercholesterolemic children receiving colestipol resin. Pediatr Res 1978;12(10):980-982.
- .Tsugeno H, Nakai M, Okamoto M, et al. Assessment of etidronic acid plus alfacalcidol for the treatment of osteopenia in steroid-dependent asthmatics: a pilot study of five cases. Clin Drug Invest 2003;23(2):99-105.
- .Tsuritani I, Brooke-Wavell KS, Mastana SS, et al. Does vitamin D receptor polymorphism influence the response of bone to brisk walking in postmenopausal women? Horm Res 1998;50(6):315-319.
- .Tuohimaa P, Lyakhovich A, Aksenov N, et al. Vitamin D and prostate cancer. J Steroid Biochem Mol Biol 2001;76:125-134.
- .Tuohimaa P, Tenkanen L, Ahonen M, et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer 2004;108(1):104-108.
- .Turnquist J, Ornoy A, Eini D, et al. Effects of 1 alpha(OH)-vitamin D3 and 24,25(OH)2-vitamin D3 on long bones of glucocorticoid-treated rats. Acta Anat (Basel) 1992;145(1):61-67.
- .USDA: Composition of foods: USDA handbook #8. Washington, DC: ARS, USDA; 1976-1986.
- .Uusi-Rasi K, Semanick LM, Zanchetta JR, et al. Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone 2005;36(6):948-958.
- .Vandevyver C, Wylin T, Cassiman JJ, et al. Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. J Bone Miner Res 1997;12(2):241-247.
- .Van Veldhuizen PJ, Taylor SA, Williamson S, et al. Treatment of vitamin D deficiency in patients with metastatic prostate cancer may improve bone pain and muscle strength. J Urol 2000;163:187-190.
- .Veeninga AT, Wielders JP, Oosterink J. [A pilot study of vitamin D in psychogeriatric patients: 82% is (severely) deficient.] Tijdschr Gerontol Geriatr 2004;35(5):203-206. [Dutch]
- .Vieth R. Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. J Nutr 2006;136(4):1117-1122. (Review)
- .Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69(5):825-826. (Review)
- .Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 2001;73(2):288-294.
- .Vieth R, Kimball S. Vitamin D in congestive heart failure. Am J Clin Nutr 2006;83:731-732. (Editorial)
- .Vieth R, Kimball S, Hu A, et al. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J 2004;3(1):8.
- .Viljakainen HT, Natri AM, Karkkainen M, et al. A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res 2006;21(6):836-844.
- .Villar J, Abdel-Aleem H, Merialdi M, et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006;194(3):639-649.
- .Villareal DT, et al. Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. J Clin Endocrinol Metab 1991;72(3):628-634.
- .Wactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006;354(7):684-696.
- .Wang JT, Lin CJ, Burridge SM, et al. Genetics of vitamin D 1-hydroxylase deficiency in 17 families. Am J Hum Genet 1998;63:1694-1702.
- .Wang L, Whitlatch LW, Flanagan JN, et al. Vitamin D autocrine system and prostate cancer. Recent Results Cancer Res 2003;164:223-237. (Review)
- .Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 1997;96(6):1755-1760.
- .Weaver CM. 2003 W. O. Atwater Memorial Lecture: defining nutrient requirements from a perspective of bone-related nutrients. J Nutr 2003;133(12):4063-4066.
- .Weaver CM, Fleet JC. Vitamin D requirements: current and future. Am J Clin Nutr 2004;80:1735S-1739S.
- .Weisman Y, Schen RJ, Eisenberg Z, et al. Inadequate status and impaired metabolism of vitamin D in the elderly. Isr J Med Sci 1981;17(1):19-21.
- .Weisberg P, Scanlon KS , Li R, et al. Nutritional rickets among children in the United States: review of cases reported between 1986 and 2003. Am J Clin Nutr 2004;80:1697S-1705S.
- .Werbach MR. Foundations of nutritional medicine. Tarzana, CA: Third Line Press; 1997. (Review)
- .Whitfield GK, Selznick SH, Haussler CA, et al. Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Mol Endocrinol 1996;10:1617-1631.
- .Whiting SJ, Calvo MS. Overview of the proceedings from Experimental Biology 2005 Symposium: optimizing vitamin D intake for populations with special needs: barriers to effective food fortification and supplementation. J Nutr 2006;136(4):1114-1116.
- .Wilkinson RJ, Llewelyn M, Toossi Z, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 2000;355(9204):618-621.
- .Willing M, Sowers M, Aron D, et al. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res 1998;13(4):695-705.
- .Willis CM, Laing EM, Hall DB, et al. A prospective analysis of plasma 25-hydroxyvitamin D concentrations in white and black prepubertal females in the southeastern United States. Am J Clin Nutr 2007;85(1):124-130.
- .Winzenberg TM, Shaw K, Fryer J, et al. Calcium supplementation for improving bone mineral density in children. Cochrane Database Syst Rev 2006;(2):CD005119. (Review)
- .Winzenberg T, Shaw K, Fryer J, et al. Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials. BMJ 2006;333(7572):775. (Review)
- .Wootton AM. Improving the measurement of 25-hydroxyvitamin D. Clin Biochem Rev 2005;26:33-36.
- .Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72(3):690-693.
- .Wright RJ. Make no bones about it: increasing epidemiologic evidence links vitamin D to pulmonary function and COPD. Chest 2005;128(6):3781-3783. (Editorial)
- .Yamashita H, Noguchi S, Takatsu K, et al. High prevalence of vitamin D deficiency in Japanese female patients with Graves’ disease. Endocr J 2001;48(6):63-69.
- .Yanase T, Suzuki S, Goto K, et al. Aromatase in bone: roles of vitamin D(3) and androgens. J Steroid Biochem Mol Biol 2003;86(3-5):393-397.
- .Yang Y-X, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 2006;296:2947-2953.
- .Yeh JK, Aloia JF, Semla HM. Interrelation of cortisone and 1,25 dihydroxycholecalciferol on intestinal calcium and phosphate absorption. Calcif Tissue Int 1984;36(5):608-614.
- .Young MV, Schwartz GG, Wang L, et al. The prostate 25-hydroxyvitamin D-1-alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis 2004;25:967-971.
- .Yu JW, Pekeles G, Legault L, et al. Milk allergy and vitamin D deficiency rickets: a common disorder associated with an uncommon disease. Ann Allergy Asthma Immunol 2006;96(4):615-619. (Case report)
- .Zeghoud F, Ben-Mekhbi H, Djeghri N, et al. Vitamin D prophylaxis during infancy: comparison of the long-term effects of three intermittent doses (15, 5, or 2.5 mg) on 25-hydroxyvitamin D concentrations. Am J Clin Nutr 1994;60(3):393-396.
- .Zeghoud F, Vervel C, Guillozo H, et al. Subclinical vitamin D deficiency in neonates: definition and response to vitamin D supplements. Am J Clin Nutr 1997;65(3):771-778.
- .Zhang YY, Long JR, Liu PY, et al. Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women. Biochem Biophys Res Commun 2003;308(4):777-783.
- .Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003;89(5):552-572. (Review)
- .Zittermann A, Schleithoff SS, Tenderich G, et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 2003;41(1):105-112.
- .Zittermann A. Serum 25-hydroxyvitamin D response to oral vitamin D intake in children. Am J Clin Nutr 2003;78(3):496-497.